Sentences with phrase «+ luminal»
In this study published in Cell Reports, Alexandra Van Keymeulen and colleagues generated a new transgenic line - allowing lineage tracing of ER + luminal cells to investigate luminal cell heterogeneity and identify the origin of ER + luminal cells and the mechanisms regulating their pubertal expansion and adult maintenance.
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This model should be a powerful tool for testing therapies for aggressive ER + breast cancers and for studying luminal cancers — the most prevalent and deadliest forms of breast cancer.
Title: Developmental stage - specific contribution of LGR5 + cells to basal and luminal epithelial lineages in the postnatal mammary gland Authors: de Visser KE, Ciampricotti M, Michalak EM, Wei - Min Tan D, Speksnijder EN, Hau C - S, Clevers H, Barker N, Jonkers J Date: 2012 Publication Details: The Journal of Pathology 2011 May; 224 (1): 56 - 66
Our bioinformatics analysis, based on multiple independent large - size cohorts shows that MELK is strongly overexpessed in BBC / TNBC, not only compared to normal breast tissues, but also compared to luminal or ER / PR + breast cancer.