Sentences with phrase «+ macrophage»

Movement across the CD169 + macrophage layer into the sinus is promoted by S1pr1 and lymphatic endothelial cell - derived S1P.

A loss of Vγ4 + Ccr6 + cells was also observed following CD169 + macrophage ablation using CD169 - DTR mice (Figure 7F).

Adipose tissue within muscle contained significant numbers of F4 / 80 + macrophages, and the percentage of F4 / 80 + cells within this adipose tissue was markedly increased in obese mice compared with lean mice (41 % ± 4 % of macrophages vs. 12 % ± 2 % of macrophages, respectively; P < 0.005, mean ± SD)(Figure 4).

In mice, both body mass and adipocyte size were strong predictors of the percentage of F4 / 80 + macrophages in the perigonadal, perirenal, mesenteric, and subcutaneous adipose tissue depots.

Bone marrow CD169 + macrophages promote the retention of hematopoietic stem and progenitor cells in the mesenchymal stem cell niche.

The greater CD169 coating of Vγ4 + γδT cells and their stronger dependence on CD169 for retention in the SCS than the other innate - like lymphocytes suggests these cells interact more strongly or in a more selective way with CD169 + macrophages.

Not exact matches

There was also an enhancement of infiltrating CD8 + cells, macrophages and natural killer cells.

The researchers were also able to detect SIV DNA and RNA in the combined total SVF as well as in isolated adipose tissue macrophages and CD4 + T cells.

Moreover, these immune cells (CD4 + T cells, CD8 + T cells, and macrophages) show enhanced immune activation and / or inflammatory profiles compared with non-infected animals.

To test whether adipose tissue F4 / 80 + cells shared a common bone marrow origin with other tissue macrophage populations, we transplanted bone marrow from C57BL / 6J mice expressing the CD45.1 leukocyte marker into 6 - week - old lethally irradiated C57BL / 6J mice expressing the CD45.2 leukocyte marker.

Among the three isolated cell populations, the relative gene expression of macrophage markers was highest among the F4 / 80 + cells.

Together these data suggest that the F4 / 80 + cells identified in adipose tissue are CSF - 1 — dependent, bone marrow — derived adipose tissue macrophages.

Average adipocyte cross-sectional area and the percentage of F4 / 80 + cells (macrophages) in adipose tissue depots were determined for each mouse in this study.

Of the three adipose tissue cell populations, the F4 / 80 + adipose tissue macrophages were the predominant source of TNF - α expression.

A pair of 2 - month - old macrophage - deficient (FVB / NJ Csf1op / op) and control (FVB / NJ Csf1 + / +) female mice were a gift of E. Richard Stanley (Albert Einstein College of Medicine, New York, New York, USA).

To determine whether adipose tissue macrophages express any molecules implicated in obesity - associated complications, we isolated three cell populations from the parametrial adipose tissue of three obese B6.V Lepob / ob mice: (a) an adipocyte - enriched population, (b) a stromal vascular macrophage F4 / 80 + population, and (c) an F4 / 80 — stromal vascular population.

Immunohistochemical analysis of perigonadal, perirenal, mesenteric, and subcutaneous adipose tissue revealed that the percentage of cells expressing the macrophage marker F4 / 80 (F4 / 80 +) was significantly and positively correlated with both adipocyte size and body mass.

Flow cytometry of SVCs isolated from two perigondadal adipose tissue depot illustrates that tissue from macrophage - deficient mice (b) contains 34 % the number of F4 / 80 + cells found in adipose tissue from control mice (a).

Macrophage - deficient FVB / NJ Csf1op / op mice are also deficient in F4 / 80 + cells in adipose tissue.

Macatonia SE, Hsieh C - S, Murphy KM, O'Garra A. Dendritic cells and macrophages are required for Th1 development of CD4 + T cells from alpha beta TCR transgenic mice IL - 12 substitution for macrophages to stimulate IFN - gamma production is IFN - gammadependent.

Macrophage response (IBA1 + cells) was significantly higher in the 3 - NP control compared to the the sham or iPSC - treated rats suggesting that the iPSCs do not generate a significant host macrophageMacrophage response (IBA1 + cells) was significantly higher in the 3 - NP control compared to the the sham or iPSC - treated rats suggesting that the iPSCs do not generate a significant host macrophagemacrophage response.

Moreover, there are yet other cell types — such as visceral adipose tissue macrophages and cytotoxic CD8 + T - cells — in which the age - related supernumerary accumulation of dysfunctional and apoptosis - resistant cells appears to play a highly deleterious role on tissue function, but where the cells are not «senescent» cells in the classical sense of p16Ink4a expression and the senescence - associated secretory profile observed in senescent fibroblasts.

CD4 + T Cells Are as Protective as CD8 + T Cells against Rickettsia typhi Infection by Activating Macrophage Bactericidal Activity.

Cxcr6 - GFP + cells appear attached to CD11b + SCS macrophages (red) while being buffeted by bulk lymph flow in the SCS, yielding a characteristic fluttering dynamic (video inset and arrowheads).

The depth of the subcapsular sinus in individual LNs varied, and for each experiment was computationally determined as the peak frequency on a plot of CD11b + subcapsular macrophage's depth below the LN capsule, minus 2 µm, which agreed across experiments with visual estimates of the subcapsular sinus site.

The positions of both Cxcr6 + cells and CD11b + subcapsular macrophages were determined using spots objects in Imaris.