Tissue DNA was subjected to amplification of a region within the 5s -
23s ribosomal genes using a nested set of primers.
Biochemical and crystallographic evidence suggests that
23S ribosomal RNA (rRNA) is the catalyst of peptide bond formation.
The contacts between wild - type M1 RNA and its substrate are in a region that resembles part of the transfer RNA «E» (exit) site in
23S ribosomal RNA.
Not exact matches
Both substrate analogs are contacted exclusively by conserved
ribosomal RNA (rRNA) residues from domain V of
23S rRNA; there are no protein side - chain atoms closer than about 18 angstroms to the peptide bond being synthesized.