Sentences with phrase «3d cell cultures»

Recently, there has been an increased drive to develop assays and readers for 3D cell cultures.

Researchers are increasingly using 3D cell cultures to study the skin's features.

Companies making high - content cell imaging equipment such as confocal microscopes and plate readers are now adding software tools to process images of 3D cell cultures.

The ability to automate morphology assays on 3D cell cultures is a powerful tool, but some scientists are now pushing the technology even further, with algorithms that can classify structures in living animals and clinical specimens.

As a result, 3D cell culture systems have become a staple of cell biology.

He now juggles two jobs: he is a project manager for the University of Oxford's technology transfer subsidiary ISIS Innovation, as well as managing director of one of its break - out firms, Zyoxel, which develops simple microbioreactors, devices that enable cost - effective 3D cell culture.

M. Thompson, M. Tsurkan, K. Chwalek, M. Bornhauser, M. Schlierf, C. Werner, Y. Zhang Self - Assembling Hydrogels Crosslinked Solely by Receptor - Ligand Interactions: Tunability, Rationalization of Physical Properties and 3D Cell Culture.

3D cell culture provides a biomimetic model of cell systems for many applications including cell / tissue models and constructs for basic / medical research, product testing, and regenerative medicine.

One way around that problem is to work with another kind of 3D cell culture known as a spheroid, which hasn't yet gone too far down the path of development and still contains mostly identical, similarly differentiated cells.

This finding further validates our 3D cell culture devices as an experimental model for future glaucoma studies.»

Dr. Komatsu and his colleagues, Dr. Fangfei Li and Dr. Junko Sawada, used a combination of 3D cell culture and living tissue to show that VEGF promotes vascularization, but the vessel structures formed are chaotic, unstable and non-functional.

Our results demonstrated that our 3D cell culture device enables a real - time imaging of giant vacuole formation and tracers crossing the cultured endothelial cell monolayer in a controlled experimental condition.

Our goal is to create a microfluidic 3D cell culture system representing a «placenta - on - a-chip» in order to mimic the nutrient / waste transfer between maternal blood and fetal blood that occurs in the cotyledon section of the placenta, and to test and observe the effects of ethanol within the maternal bloodstream and compare it to a similar in vivo situation.

Not exact matches

Based on a 3D image such as an MRI scan, Aspect's machine builds relatively complex organic structures out of a «hydrogel» embedded within cells taken from the body and grown in a cell culture.

While scientists have previously had success in 3D printing a range of human stem cell cultures developed from bone marrow or skin cells, a team from Scotland's Heriot - Watt University claims to be the first to print the more delicate, yet more flexible, human embryonic stem cells (hESCs).

«Signaling pathways and gene expression profiles are very different in cells that grow in 2D and 3D cultures,» says Oksana Sirenko, a research scientist at Molecular Devices in Sunnyvale, California.

Besides displaying more natural signaling patterns, 3D cultures allow researchers to mix cell types in ways that mimic their interactions in living tissue, providing more accurate models of normal physiology and pathogenesis.

In a typical 3D culture system, cells cling to each other, forming spheroids that float in liquid culture media or expand into a soft matrix.

We were able to use pharmaceuticals to induce cell self - eating effects and stimulate dedifferentiation though not as effectively as 3D culture, so we need to do more work on this.

Her team decided to try a cell - growing approach, called 3D cultures, that's been successful for other types of cells that need to form complex structures as they grow.

«We have provided a scalable and versatile 3D cancer model that shows a greater resemblance to natural cancer than 2D cultured cancer cells,» says the lead author, Professor Wei Sun of Tsinghua University in China and Drexel University in the United States.

The scientists used 3D printing of cells and nanoparticles followed by cell culture to combine a small coil antenna with cartilage, creating what they term a bionic ear.

«The resulting hydrogel composed of physically self - assembled CarHC polymers exhibited a rapid gel - sol transition on light exposure, which enabled the facile release / recovery of 3T3 fibroblasts and human mesenchymal stem cells (hMSCs) from 3D cultures while maintaining their viability.»

Indeed, when JQ1 was added to the 3D culture system, it reversed the genetic changes to the pancreatic cancer cells that the stromal signals had caused.

Specific duties will include basic and advanced polymer chemistry protocols, cell culture and expansion, hydrogel biomaterial characterization, physical characterization of biomaterials, assembly of 3D constructs using biofabrication and bioprinting techniques, collection and organization of data, and assisting in the preparation of reports and manuscripts.

Quantification of dynamic morphological drug responses in 3D organotypic cell cultures by automated image analysis.

A novel 3D mammalian cell perfusion - culture system in microfluidic channels.

Differential osteogenicity of multiple donor - derived human mesenchymal stem cells and osteoblasts in monolayer, scaffold - based 3D culture and in vivo.

Reduced contraction of skin equivalent engineered using cell sheets cultured in 3D matrices.

We use 3D stem cell («organoid») cultures from mice and humans to examine occurrence, level and molecular causes of CIN in cancer (Video 2).

To highlight the potentially important role of 3D culture conditions, the authors compared 2D monolayers of hepatocyte progenitors, fetal liver stromal cells, or adult bone marrow - derived stromal progenitor cells to their 3D counterparts cultured on liver extracellular matrix (3D - ECM) constructs.

Scientists at the University of Cambridge have managed to create a structure resembling a mouse embryo in culture, using two types of stem cells — the body's «master cells» — and a 3D scaffold on which they can grow.

The Chips are cultured under continuous flow within engineered 3D microenvironments that go beyond conventional 3D in vitro models by recapitulating in vivo intercellular interactions, spatiotemporal gradients, vascular perfusion, and mechanical forces — all key drivers of cell architecture, differentiated function, and gene expression.

(required) Advanced Cell Culture: 3D, Fluid Flow and Co-cultureIn Vitro Models for the Study of Neurological DiseasesStem Cells: Developing Off the Shelf TherapeuticsCreating More Realistic Gut ModelsIn Vitro Models for Animal Replacement

The primary epithelial cells are expanded as 3D organoids, dissociated, and cultured on a porous membrane within a microfluidic device with human intestinal microvascular endothelium cultured in a parallel microchannel under flow and cyclic deformation.

Viral Manufacturing To manufacture viral vectors, two approaches generally are adopted for culturing purposes: scale - out of adherent - cell systems based on 2D planar technologies and scale - up of 3D suspension cell cultures in stirred - tank bioreactors.

This article describes methods for preparation and imaging of 3D cancer cell cultures, either as single cells or spheroids.

In particular, we use 2D and 3D in vitro cell cultures; tissue slices cultured ex vivo; and transgenic mouse models.

In this study, we modified and applied a three - dimensional (3D) cell culture device which was recently developed at MIT to study the dynamics of Schlemm's canal endothelial cells.

Using high throughput robotic platforms and 3D multicellular tumor spheroid cell culture models for high throughput RNAI and drug screens for target identification and validation

In the November 6 Nature Methods, the team led by Bing Lim and Massimo Nichane of the Genome Institute of Singapore and Kyle M. Loh of Stanford University School of Medicine, and including Siva V, Ph.D., of The Jackson Laboratory's Single Cell Biology Lab, showed that mouse Sox9 + multipotent embryonic lung progenitors can be isolated and expanded long - term in 3D culture.

Both normal and cancer breast stem cells give rise to 3D mammospheres in suspension culture.

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