Sentences with phrase «3d culture systems»

«As bioengineers, we can now design 3D culture systems where environmental parameters such as composition, porosity, and stiffness can be precisely tuned to study the importance of these cues on tumorigenesis,» says coauthor Sandeep Koshy, a Harvard graduate student in the Harvard - MIT Program in Health Sciences and Technology, who works in Mooney's lab at Harvard SEAS and at the Wyss Institute for Biologically Inspired Engineering.

Now, a combination of innovative 3D culture systems, automated image analysis, and sophisticated microscopic shape mapping is driving a rush of groundbreaking discoveries.

In a typical 3D culture system, cells cling to each other, forming spheroids that float in liquid culture media or expand into a soft matrix.

Indeed, when JQ1 was added to the 3D culture system, it reversed the genetic changes to the pancreatic cancer cells that the stromal signals had caused.

Not exact matches

«It took us a few years to optimize our 3D skin organoid culture system.»

As a result, 3D cell culture systems have become a staple of cell biology.

We're now exploiting these ideas in the construction of high performance electronic scaffolds for actively guiding and monitoring growth of tissue cultures, and networks for 3D electronic systems that can bend and shape themselves to the organs of the human body.

A novel 3D mammalian cell perfusion - culture system in microfluidic channels.

Using three - dimensional (3D) culture systems to delineate the role of RANKL in metastatic prostate cancer.

Microphysiological systems (MPSs) are in vitro models that capture facets of in vivo organ function through use of specialized culture microenvironments, including 3D matrices and microperfusion.

3D cell culture provides a biomimetic model of cell systems for many applications including cell / tissue models and constructs for basic / medical research, product testing, and regenerative medicine.

Viral Manufacturing To manufacture viral vectors, two approaches generally are adopted for culturing purposes: scale - out of adherent - cell systems based on 2D planar technologies and scale - up of 3D suspension cell cultures in stirred - tank bioreactors.

In addition, 3D cultures can be maintained for very long periods (over 850 days according to work from the Pasca Lab) and therefore can be used to study maturation in the nervous system.

A complex extracellular matrix is used for the maturation of CLCs; therefore, experience in hPSC culture and 3D organoid systems may be necessary for optimal results.

Our goal is to create a microfluidic 3D cell culture system representing a «placenta - on - a-chip» in order to mimic the nutrient / waste transfer between maternal blood and fetal blood that occurs in the cotyledon section of the placenta, and to test and observe the effects of ethanol within the maternal bloodstream and compare it to a similar in vivo situation.

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