The combination allows for the study of
3D subcellular processes in their native multicellular environments at high spatiotemporal (space and time) resolution.
Adaptive optical lattice light - sheet microscopy permits delicate
3D subcellular processes to be viewed natively in vivo.
Not exact matches
Using cutting - edge
3D microscopy, researchers from the National Heart, Lung, and Blood Institute and Yale University examined the
subcellular architecture of presynaptic terminals in retinal bipolar cells of live goldfish.
We demonstrated the technique on 20 different biological processes spanning four orders of magnitude in space and time, including the binding kinetics of single Sox2 transcription factor molecules,
3D superresolution photoactivated localization microscopy of nuclear lamins, dynamic organelle rearrangements and
3D tracking of microtubule plus ends during mitosis, neutrophil motility in a collagen mesh, and
subcellular protein localization and dynamics during embryogenesis in Caenorhabditis elegans and Drosophila melanogaster.
Korenberg's team is developing a
3D coordinate system to align various types of neuroimaging data in the macaque brain, from whole - brain MRI connectivity to single - cell confocal data and, for some areas,
subcellular resolution with electron microscopy.