Sentences with phrase «a-beta plaques form»
Secreted by certain brain cells, APOE is known to regulate cholesterol metabolism within the brain and can bind to A-beta peptides, suggesting that the different forms of the protein may affect whether and how toxic A-beta plaques form.
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Earlier animal studies have shown that A-beta can move into the brain if it's injected into the bloodstream, but scientists didn't know whether A-beta from the blood can be plentiful enough to form plaques in the brain.
Song says that the experiments don't address whether A-beta from the blood can behave as a prion and prompt already existing A-beta in the brain to form plaques.
The researchers also tracked 592 people who had low levels of A-beta in their cerebral spinal fluid — a clue that plaques have formed in the brain — and who showed symptoms of Alzheimer's.
Among other results, he has found that the plaque - forming a-beta protein disrupts neuronal function and connectivity even before amyloid plaques accumulate, a finding with important implications for understanding AD pathogenesis.