Sentences with phrase «a549 lung cancer cells»

... In lung cancer cell lines, CBD upregulated ICAM - 1, leading to...

A protein called YAP1 was previously shown to contribute to the growth of lung cancer cells; however, it was unknown how YAP1 controls lung cancer growth and progression.

Following their recent discovery of a protein pathway, Moffitt Cancer Center researchers are one step closer to understanding how lung cancer cells metastasize.

Scientists from Moffitt reported in the Jan. 19 online edition of Cancer Research that nicotine induces the metastatic spread of lung cancer cells by stimulating a protein called beta - arrestin - 1.

The researchers confirmed this hypothesis by showing that if they blocked YAP1 they could inhibit stem cells from undergoing self - renewal, forming blood vessel - like structures, and reduce lung cancer cell growth in mice.

Activation of beta - arrestin - 1 causes lung cancer cells to produce proteins associated with increased motility and invasion.

«These occult lung cancer cells have found a unique way to co-opt the «brain microenvironment» and survive,» said Nguyen.

Soon after lung cancer cells (in green) spread into the brain, extracellular matrix molecules (in red) can shield them from the hostile surroundings.

In the lung cancer cell shown above at left, red shades indicate the presence of actin, a structural protein important in cell movement.

They found out that TiY is capable of distinguishing TICs from non-TICs in various human lung cancer cell lines and patient - derived lung tumors.

«Our study results suggest a new drug cocktail that is effective in both human lung cancer cell lines and fly models,» says Cagan.

Using both fruit fly and human lung cancer cell lines, researchers targeted two of the most common genetic mutations associated with NSCLC — Ras and PTEN (P13K).

Diluted and filtered liquid medium drawn from the fibroblast cell culture also killed breast and lung cancer cells.

Normal human colon cells, kidney cells, lung cancer cells and two strains of colon cancer cells didn't respond to the bacteria.

By using molecular genetic tools to reduce the amount of PC in human lung cancer cells, the team observed decreased cell growth, a compromised ability to form colonies in soft agar (a gelatinous material specifically used to grow bacteria and other cells), and a reduced rate of tumor growth in mice.

«We now know much more about metabolic reprogramming of cancerous tissues in human patients, particularly that the activation of pyruvate carboxylase is important to lung cancer cell growth and survival,» said Fan, UK professor of toxicology and faculty member of the Markey Cancer Center and CESB at the University of Kentucky.

Marcus and former graduate student Jessica Konen, PhD began by observing how a mass of lung cancer cells behaves when embedded in a 3 - D protein gel.

It is only present at low levels in lung cancer cells which are not metastatic and remain within the lung.

The Nature Communications paper covers lung cancer cells; a similar phenomenon of collective invasion led by distinctive cells has been observed in breast cancer, but different genes and biochemical pathways appear to be important in each system.

Researchers from the University of Portsmouth's Brain Tumour Research Centre of Excellence have identified molecules which are responsible for metastatic lung cancer cells binding to blood vessels in the brain.

In tests on EGFR - dependent lung cancer cell lines, Tan and colleagues show that the drugs gefitinib and bosutinib «showed additive and synergistic effects.»

SLex is also found on the surface of lung cancer cells and colon cancer cells, which are also seeking E-selectin sites to attach themselves to as they spread around the body.

Scientists from the Cancer Research UK Manchester Institute, based at The University of Manchester and part of the Manchester Cancer Research Centre, teamed up with experts at AstraZeneca, as part of a collaboration agreed in 2010, to test a drug — known as AZD3965 — on small cell lung cancer cells.

The Manchester researchers tested a new drug that targets one of these molecules, MCT1, in lung cancer cells and in mouse models.

«New drug active against most aggressive type of lung cancer cells.»

«When we treated lung cancer cells with the antifungal drug, we saw the antiviral protection from IFITM3 pretty much disappear,» explained Christopher Chin, co-first author, also from UMMS.

Cancer Research UK scientists have found a drug combination that can trigger the self - destruct process in lung cancer cells — paving the way for new treatments, according to research that will be presented at the National Cancer Research Institute (NCRI) Cancer Conference in Liverpool.

They bathed a relatively benign strain of lung cancer cells in cyclosporine.

The Cancer Research UK team, based at the UCL Cancer Institute, has successfully fixed this fault in lung cancer cells — reprogramming the cells to self - destruct.

Using lung cancer cells and mice the scientists showed that the combination of two drugs, called TRAIL and a CDK9 inhibitor, altered the molecular switches in the cell suicide process — forcing the cancer cells to self - destruct.

Lead researcher, Cancer Research UK scientist Professor Henning Walczak from the UCL Cancer Institute, said: «Igniting the fuse that causes lung cancer cells to self - destruct could pave the way to a completely new treatment approach — and leave healthy cells unharmed.

They showed that it slowed the growth of human lung cancer cells but not kidney cancer cells in these mice.

ab9484 staining GAPDH in A549 lung cancer cells by Flow Cytometry.

MicroRNA -140-3p inhibits proliferation, migration and invasion of lung cancer cells by targeting ATP6AP2.

Drugs such as gefitinib and erlotinib are supposed to block those growth signals in lung cancer cells, but not every cancer responds to them.

Wang's team discovered that if human lung cancer cells in a lab dish in the presence of the receptor were treated with BCX, they migrated less than untreated ones.

Regulation of cellular proliferation, cytoskeletal function, and signal transduction through CXCR4 and c - Kit in small cell lung cancer cells.

Effects of the proteasome inhibitor bortezomib alone and in combination with chemotherapy in the A549 non-small-cell lung cancer cell line.

Functional expression of CXCR4 (CD184) on small - cell lung cancer cells mediates migration, integrin activation, and adhesion to stromal cells.

Treatment of lung cancer cell lines with mebendazole caused mitotic arrest by depolymerization of tubulin, followed by apoptotic cell death.

We screened the coding sequences of 518 protein kinases (approximately 1.3 Mb of DNA per sample) for somatic mutations in 26 primary lung neoplasms and seven lung cancer cell lines.

Together with oncologist William Pao, she uncovered differences in the growth dynamics of non-small cell lung cancer cells that are either resistant or susceptible to the targeted drug Tarceva.

Scientists discover that a regulator of inflammation plays a key role in the proliferation of lung cancer cells

Testing the system with lung cancer cells, the researchers showed that the ligand - guided protein cages selectively penetrated and killed more than 70 percent of the cancer cells.

I wanted to inactivate the gene BRAF (a kinase implicated in several human cancers) in A549 cells (a human lung cancer cell line), armed only with viruses obtained through Addgene's viral service and the methods sections of scientific articles (gasp).

And City of Hope is a leader in personalized medicine, including clinical trials here that are finding new and more effective drug combinations to kill lung cancer cells.

(a kinase implicated in several human cancers) in A549 cells (a human lung cancer cell line), armed only with viruses obtained through Addgene's viral service and the methods sections of scientific articles (gasp).

While some research has been done on using apoferritin for drug delivery, this is the first time it was used to target lung cancer cells.

Shapiro GI, Koestner DA, Matranga CB, et al: Flavopiridol induces cell cycle arrest and p53 - independent apoptosis in non-small cell lung cancer cell lines.

The name «small cell» refers to the appearance of these lung cancer cells under a microscope.