Sentences with phrase «abl positive»

The best example of this scenario comes from BCR - ABL positive neoplasms.

This gatekeeper Thr residue is not conserved in the JAK kinase family, but the Phe958 residue of JAK1 is the homologous residue of Phe317 in ABL kinase, which is close to the gatekeeper residue and was also found to be mutated in imatinib - resistant BCR - ABL positive patients13, 29,30 (Online Supplementary Figure S6A and S6B).

To test the theory, Arlinghaus and colleagues first demonstrated that BCR - ABL positive cells expressed 24p3 and secreted it into the surrounding tissue, causing cell death.

Not exact matches

Enhanced phosphorylation of Nbs1, a member of DNA repair / checkpoint complex Mre11 - RAD50 - Nbs1, can be targeted to increase the efficacy of imatinib mesylate against BCR / ABL - positive leukemia cells.

These mutant kinases are attractive therapeutic targets, as demonstrated by the efficacy of imatinib in BCR - ABL — positive chronic myelogenous leukemia (CML), 5 as well as in MPD associated with activating alleles involving PDGFRA or PDGFRB.2, 6,7 In addition, activating mutations in the FLT3 receptor tyrosine kinase are the most common genetic event in acute myeloid leukemia (AML), and specific inhibitors of the FMS - like tyrosine kinase 3 (FLT3) have entered late - stage clinical trials.8 Although mutations in tyrosine kinases and in other genes have been identified in a subset of MPD and AML, in many cases the genetic events that contribute to the molecular pathogenesis of these diseases remain unknown.