Sentences with phrase «alk gene»
Lemmon is collaborating with oncologists at Penn who have sequenced the ALK gene in nearly 2000 neuroblastoma tumors and found 50 different mutations.
https://sbgrid.org/
• Testing revealed an ALK gene rearrangement when a sample of a patient's uterine leiomyosarcoma was profiled.
The test uses dyes — in this case orange and green — that bind to separate halves of the ALK gene.
Next came the test to see if Martensen's tumor contained the ALK mutation, which occurs when a section of DNA in the ALK gene, located on chromosome 2, breaks apart.
Dorothy Romanus, lead author of the study, states «this analysis supports the value of multiplexed testing for EGFR and ALK gene rearrangements followed by molecularly - guided therapy in decisions surrounding coverage of related testing and targeted therapy.
«We look forward to conducting further research through the STARTRK - 2 phase II trial and are hopeful that treatment with entrectinib in patients with a range of advanced or metastatic solid tumors harboring NTRK1 / 2/3, ROS1, or ALK gene fusions will result in very meaningful benefit.»
Among patients with non-small cell lung cancer (NSCLC) fueled by ALK gene alterations who were being treated with crizotinib (Xalkori), a decrease in the number of circulating tumor cells (CTCs) harboring increased copies of the ALK gene over the first two months of treatment was associated with increased progression - free survival.
After enriching for CTCs, the researchers analyzed the samples for ALK rearrangements and for an increase in the number of copies of the ALK gene.
About 4 percent of NSCLCs are driven by genetic aberrations called ALK gene rearrangements, according to Farace.
Now, through an unexpected observation and a meticulous study of patients seen at Brigham and Women's Hospital, BWH investigators have added a fourth cause to the list: a genetic rearrangement in the ALK gene, observed in three patients with peritoneal mesothelioma.
The ALK gene is important during embryonic development of the nervous system but should be inactive later in life.
«Rare genetic cause of peritoneal mesothelioma points to targeted therapy: Genetic rearrangement in the ALK gene found in young women with mesothelioma may be targetable with FDA - approved drugs.»
The immunotherapy drug pembrolizumab, when combined with chemotherapy, doubles survival in patients with non-squamous non-small cell lung cancer (NSNSCLC) lacking genetic changes in the EGFR or ALK genes, when compared to...
Not exact matches
Previous studies of genetic alterations in lymphoma and lung cancer have found that certain genetic mutations — specifically when part of a gene breaks off and gets fused to another — can inappropriately switch on ALK, driving cancer cells to grow and divide.
Multiplexed genetic screening for epidermal growth factor receptor (EGFR) and anaplastic lymphoma kinase (ALK) gene rearrangements and subsequent biomarker - guided treatment is cost - effective compared with standard chemotherapy treatment without any molecular testing in the metastatic non-small cell lung cancer (NSCLC) setting in the United States.
Some patients with non-small cell lung cancer (NSCLC) have changes in the anaplastic lymphoma kinase (ALK) gene, which can drive the development of their cancer.
The abnormality in ALK that arises in NSCLC is not, strictly speaking, a mutation (a change in the sequence of DNA within a gene).
«ALK now becomes the second abnormal gene that we are able to successfully target in lung cancer with drugs other than chemotherapy.»
The advent of therapies directed at tumors with mutations in epidermal growth factor receptor (EGFR), anaplastic lymphoma kinase (ALK), and B - Raf proto - oncogene (BRAF) genes over the past decade have dramatically changed outcomes, he says.
The NIH and Mass General are at the vanguard of a major effort to identify and treat cancer based on causative gene mutations like the one found in ALK.
But the diagnostic test, which checks to see if a patient's tumor carries a mutation in a gene coding for anaplastic lymphoma kinase, called ALK, is just $ 250.
The super-enhancers switched on known cancer genes, including genes like ALK, MYC, SMO and OTX2 that are associated with medulloblastoma, researchers reported.
Our primary aim is to identify subgroups of rNB patients who have potentially targetable genetic (ALK, MAPK pathway, Metabolic - related genes) and / or immunologic (tumor - associated macrophage infiltration and / or programmed death ligand [PD - L1] expression) biomarkers in rNB.
These results suggest that inhibition of mTOR - raptor complex or silencing mTOR gene expression induced cell cycle arrest at G1 phase in ALK + ALCL cells.
Finally, a large subset of genes is linked to brain development, including neural growth (NINJ1, NTM), axon and glial guidance (MATN2, DCC, ASTN1), synapse plasticity (DLGAP1), neurogenesis (ALK, NUMB) and a variety of neurological disorders.
A subset of ALCL tumors carries chromosomal aberrations involving the anaplastic lymphoma kinase (alk) gene on chromosome 2p23 resulting in ALK overexpression (alk) gene on chromosome 2p23 resulting in ALK overexpression (ALK overexpression (2).
We also show that inhibition of mTOR with rapamycin, as well as silencing mTOR gene product expression using mTOR - specific small interfering RNA, decreased phosphorylation of mTOR signaling proteins and induced cell cycle arrest and apoptosis in ALK + ALCL cells.