Sentences with phrase «as fibrils»

Primary light - chain - associated (AL) amyloidosis is characterized by the deposition in tissue of monoclonal light chains as fibrils.

(10) The company's scientists also report that when they then injected preformed AS fibrils into the brains of mice, BIIB054 slowed the self - templating spread of AS pathology across the brain (consistent with their cell - culture study), and held much of the ensuing motor dysfunction at bay (9,10)(reducing it «by more than 50 percent» according to a science journalist who was present when they presented results at AD / PD 2017 (11)-RRB-.

Not exact matches

To create a new bioink, Gatenholm's team mixed polysaccharides from brown algae and tiny cellulose fibrils from wood or made by bacteria, as well as human chondrocytes, which are cells that build up cartilage.

No one knows for certain what the fibrils are — whether they are the agents of the disease, a type of subviral particle, as some researchers suggest, or are a product of the disease.

While these compounds did not reduce the amount of protein aggregates, they were found to reduce the protein's toxicity and to increase the stability of amyloid fibrils — a finding that lends further evidence to the theory that smaller assemblies of amyloid - beta known as oligomers, and not the fibrils themselves, are the toxic agents responsible for Alzheimer's symptoms.

The structures, called amyloid fibrils, are also implicated in neurodegenerative conditions such as Alzheimer's and Parkinson's, and in prion diseases like Creutzfeldt - Jacob and mad cow disease.

An earlier study indicated that the intermediate step was likely a floppy loop area formed by proteins, which didn't seem compatible with the tough, damaging fibril as an end result.

More than 40 illnesses known as amyloid diseases — Alzheimer's, Parkinson's and rheumatoid arthritis are a few — are linked to the buildup of proteins after they have transformed from their normally folded, biologically active forms to abnormally folded, grouped deposits called fibrils or plaques.

For prevention studies, they injected mouse α - syn synthetic preformed fibrils into wild - type, normal mice, as a control, and then immediately treated the mice with Syn303, one of the MAbs used (or IgG, another type of common antibody, for the control mice).

«Fibrils are remarkably strong and, as such, are a good barometer for this method's ability to form two - dimensional structures,» observes Seeman.

For example, clumps of proteins called amyloid fibrils are thought to be the cause of Alzheimer's disease as well as several other devastating illnesses.

If the newly discovered beta - sheet structure idea could be integrated as building blocks into such artificially designed proteins, it would improve their ability to attach to the disease - causing fibrils — a first step in the development of new agents against Alzheimer's and other neurodegenerative diseases.

They stabilize the fibrils — as can now be seen — by changing the blueprint of the protein at defined locations.

«NMR enabled us to obtain additional information such as which amino acid residues form salt bridges thus enhancing the stability of the fibrils,» explains Prof. Henrike Heise from Heinrich Heine University Düsseldorf and Jülich's Biomolecular NMR Center.

And that sequence can form long chains called oligomers as well as fibers called fibrils.

The amyloid - beta bound itself to C. albicans and grew fibrils that entombed the fungal invader — and as part of that process, created plaques of amyloid - beta.

Amyloid - β 42 (Aβ42) has a strong ability to oligomerize to form diffusible oligomers as well as larger polymers called fibrils that form insoluble amyloid plaques, a major hallmark of AD.

Whereas PD motor symptoms are driven by loss of dopamine - producing neurons, many of the nonmotor symptoms are instead linked to the accumulation of Lewy bodies and other malformed clumps and fibrils of the protein alpha - synuclein (AS) inside and between neurons.

«Amyloid fibrils are normally only found in diseases caused by protein misfolding, such as Alzheimer's or Parkinson's disease, so the natural presence of multiple amyloids in the semen of healthy men was completely unexpected,» said Warner C. Greene, MD, PhD, senior investigator and director of the Gladstone Institute of Virology and Immunology.

The mutant form, though, forms amyloid fibrils, as many proteins will do under the right (wrong?)

They found that abnormal clumps of α - Syn formed by small fibrils act as «seeds» that induce normal α - Syn molecules to misfold and form aggregates.

The strong covalent and H - bonds within and among the cellulose molecules and fibrils are able to resist high tensile stresses, which is why people have used wood as a building material throughout history.

A 2009 study published in the «Journal of Agricultural and Food Chemistry» showed that nattokinase was able to degrade amyloid fibrils in vitro and may potentially be useful for treating amyloid - related diseases such as Alzheimer's disease.