Sentences with phrase «abl kinase domain»

This work, and that of colleagues Brian Druker and Novartis, led to the development of the kinase inhibitor imatinib (Gleevec) as primary therapy for chronic myelogenous leukemia (CML), and the discovery that imatinib resistance is caused by BCR - ABL kinase domain mutations.

Here patients treated with imatinib become resistant because of the acquisition of mutations in the ABL kinase domain.13

[citation needed] In 2000 Dr. John Kuriyan determined the mechanism by which STI - 571 inhibits the Abl kinase domain.

Not exact matches

Kinase domain mutants of Bcr - Abl exhibit altered transformation potency, kinase activity, and substrate utilization, irrespective of sensitivity to imKinase domain mutants of Bcr - Abl exhibit altered transformation potency, kinase activity, and substrate utilization, irrespective of sensitivity to imkinase activity, and substrate utilization, irrespective of sensitivity to imatinib