Not exact matches
The team's key discovery was that stem cells lacking an enzyme responsible for pseudouridine modification of RNA,
known as PUS7, produce
abnormal amounts of
protein.
Arising from the
abnormal buildup of a
protein known as alpha - synuclein in the brain, such conditions damage the nerves that control blood pressure and heart rate.
When present in tumors, both
abnormal myc and
abnormal mTOR are
known to be able to rev up
protein production and to foster cell growth.
Abnormal and uncontrolled production of this class of
proteins,
known as transcription factors, allow for cells to bypass growth control mechanisms and to develop characteristics necessary for invading surrounding tissues.
It's thought that the high pressure observed in tumors is a result of these
abnormal blood vessels, which leak fluid and
proteins into the area between tumor cells,
known as the interstitial space.
Using patient - derived stem cells
known as induced pluripotent stem cells (iPSC) to study the genetic lung / liver disease called alpha - 1 antitrypsin (AAT) deficiency, researchers have for the first time created a disease signature that may help explain how
abnormal protein leads to liver disease.
The dementia in the other half appeared to have been caused by
abnormal protein deposits (
known as Lewy bodies), stroke - related tissue death (microinfarcts), cell damage, or some combination thereof.
Scientists have identified a basic pathologic process underlying Alzheimer's development that involves the formation of
abnormal protein deposits in the brain
known as beta - amyloid plaques, but they still aren't entirely sure what causes this to happen.
Although there is still a lot to learn about pathogenesis (the mechanism by which a disease is caused) of Alzheimer's yet we
know that during Alzheimer's two
abnormal proteins are made by mutated genes of the brain cells.
According to PetPlace.com, nephrotic syndrome in dogs is a disorder that involves a combination of factors:
protein in the dog's urine, a low blood
protein level, high cholesterol and
abnormal fluid accumulation
known as edema anywhere in the pet's body.