There is evidence that the expression of hundreds of
additional genes in adult rats changes in response to differences in maternal care [19].
To increase the number of women who will benefit from genetic testing for breast cancer, Rogan says doctors and government policy makers should include
additional genes in testing and consider new approaches that can interpret complete gene sequences.
Testing for
additional genes in the pathway and in a number of pathways is done through a number of commercial resources; the only other clinically relevant test is the homologous recombination defect assay, which is commercially available from Myriad Genetics.
Not exact matches
Immuno - oncology and
gene therapy are two such areas where we plan to make
additional hires
in the coming months
in an effort to ramp up our capabilities.
The first steps
in this have already been accomplished with the transplanting of
additional genes for growth hormone into sheep
in Australia to produce larger animals and therefore more wool.
The researchers identified several reasons for this: The new
gene constructs interfere with the plant's own
gene for producing growth hormones, and the
additional gene constructs were not, as intended, active solely
in the kernels, but also
in the leaves.
After finishing the survey, participants
in the study can opt for an
additional study and consider submitting DNA collected by a cheek swab to be tested for variants at the Apolipoprotein E (APOE)
gene.
The researchers then found that these same
genes carry an
additional risk for a phenomenon called spreading depolarization, a slowly - progressing, temporary electrical blackout of a region
in the brain.
Jaenisch says that the method that identified the single point mutation
in SNCA's enhancer could be used to pinpoint
additional pathogenic
genes for sporadic PD and sift through the GWAS hits for other diseases, including Alzheimer's disease, cancer, diabetes, and multiple sclerosis.
Apparently, NPAS4 accounts for some addiction - related learning and memory processes
in the brain, but not all of them, meaning that HDAC5 must be regulating
additional genes that reduce relapse events.
In an additional group of endometriosis samples biopsied from 15 women at the University of British Columbia, the scientists looked specifically for mutations in the KRAS gene, whose expression signals proteins that spur cell growth and replicatio
In an
additional group of endometriosis samples biopsied from 15 women at the University of British Columbia, the scientists looked specifically for mutations
in the KRAS gene, whose expression signals proteins that spur cell growth and replicatio
in the KRAS
gene, whose expression signals proteins that spur cell growth and replication.
Note added
in proof:
Additional evidence for CA1 - CA3 differences is provided by a recent study measuring immediate early
gene activation
in two different novel rooms (36).
Our data demonstrate the feasibility of targeted
gene disruption
in multiple rat strains within 4 months time, paving the way to a humanized monoclonal antibody platform and
additional human disease models.
An
additional study, currently available at bioRxiv, led by the researchers from the CRG and Cold Spring Harbour Laboratory, highlights the fact that a substantial part of human and mice
genes have maintained an essentially constant expression throughout evolution,
in tissues and various organs.
In experiments on cell cultures, both of these inhibitors succeeded in breaking various forms of the TKI resistance: including forms caused by additional mutations of the gene Bcr - Abl as well as those caused by large quantities of the protein Gab
In experiments on cell cultures, both of these inhibitors succeeded
in breaking various forms of the TKI resistance: including forms caused by additional mutations of the gene Bcr - Abl as well as those caused by large quantities of the protein Gab
in breaking various forms of the TKI resistance: including forms caused by
additional mutations of the
gene Bcr - Abl as well as those caused by large quantities of the protein Gab2.
«Our stem cell - based studies indicate that low - calorie sweeteners promote
additional fat accumulation within cells compared with cells not exposed to these substances,
in a dose - dependent fashion — meaning that as the dose of sucralose is increased more cells showed increased fat droplet accumulation,» said Sabyasachi Sen, M.D., Associate Professor of Medicine at George Washington University
in Washington, D.C. «This most likely occurs by increasing glucose entry into cells through increased activity of
genes called glucose transporters.»
Before the consortium came together, he had participated
in sequencing the genomes of two vocal learners, a songbird and a parrot, but he knew he couldn't do all of the
additional sequencing and analysis work that would be required to identify
genes related to vocal learning — not by himself, at least — so he teamed up with Genome 10K, a project aiming to collect genomes for 10,000 vertebrate species.
Because environmental exposures have not had time to impact IBD progression
in children, researchers have a clearer genetic picture of the disease allowing them to pick out
additional genes overlooked
in adult research, says senior study author Hakon Hakonarson, director of the Center for Applied Genomics at The Children's Hospital of Philadelphia.
Many of the
additional 38 missing
genes looked like they coded for proteins involved
in controlling the activity of other
genes.
Eight
additional affected children
in six unrelated families were found to also have disease - causing mutations
in this
gene.
The researchers scoured the already deciphered mouse genome, looking for
genes that might encode
additional receptor proteins
in its olfactory system, the sensory cells that connect the nose to the brain.
Additional analysis revealed that ChABC
gene therapy changed the way that inflammatory cells
in the region respond following injury.
Additional support could come from the chimpanzee genome, which may allow researchers to clock when the
genes for slow - twitch muscle fibers — crucial for running long distances and plentiful
in people but not chimps — diverged
in the common evolutionary history of humans and apes.
The cutting edge, however, is «
gene doping,»
in which
additional copies of a naturally - occurring
gene or modified copies may be inserted into an athlete's genome using a virus carrier.
This new
gene expression data therefore provides
additional evidence that the altered behavior of bacteria
in space results from decreased gravity driving reduced extracellular transport of molecules.
The function of these
genes were involved
in molecular maintenance strategies, such as DNA repair, chromosomal maintenance, immune response and programmed cell death The authors argue that the «slower rate of change
in these functions is consistent with increased constraint on somatic cell maintenance as would be required
in these relatively long - lived and large - bodied mammals, illustrated by the
additional large and long - lived species with slower rates
in these
genes (e.g. double - strand break repair
gene XRCC4 is also highly constrained
in elephant.»
While their preliminary experiments suggest the
genes help control fluid levels
in the cornea, Iyengar cautions that
additional laboratory models will be needed to pinpoint their precise functions.
«If successful, these new treatments could also be applicable to a variety of
additional cancers
in which both
genes are overexpressed.»
Although the
gene / cell therapy strategy was highly successful
in laboratory mice, the authors stressed that
additional research and testing are needed before the therapy could be tested
in humans.
Additional analysis showed that bile acid levels and
genes involved
in bile - acid regulation were changed
in the offspring exposed to the maternal high - fat diet.
Next they tested an
additional 27
genes that are known to be involved
in various steps of ribosome biogenesis to verify whether SSUP was required for ESC maintenance.
Additional validation was undertaken
in separate studies of children with meningococcal disease (n = 24) and inflammatory diseases (n = 48) and on published
gene expression datasets.
«We generated over 600 engineered tobacco plant lines that harbour different combinations of these
additional genes, and analysed them
in terms of the amounts of artemisinic compounds they acquired.
But
in a polyploid organism such as wheat, mutations
in individual
genes often have no apparent effect, because
additional copies of the mutated
gene compensate for the loss.
Scientist from the MPI for Heart and Lung Research
in Bad Nauheim now found that
additional genes compensate for a knocked out
gene and either attenuate consequences or completely compensate deficits.
Additional genes included
in the database could be the focus of future drug development efforts because they belong to classes of
genes that are thought to make promising drug targets.
To further explore nuclear transport's role
in Huntington's disease, Grima took lab - grown mouse neurons and used chemical switches to a) turn on both an
additional healthy copy of the RanGAP1
gene and a mutant version of Huntingtin; b) just turn on the mutant Huntingtin; or c) just turn on a healthy version of Huntingtin.
But they provide
additional gene markers
in bipolar disorder that could potentially lead to the future development of diagnostics or treatments.»
This causes only mild thalassemia, but because other
genes are deleted as well, there are
additional problems — such as birth defects and mental retardation — that do not occur
in most thalassemias.
Additional micro-patterning of the substrate changes the cytoskeleton
in the cell and the shape of the nucleus, which cause the
genes in the cell to change.
They think these
additional genes paved the way for colorful and more structured and shapely flowers
in later evolving angiosperms.
Although the cloned child will carry the same problem
genes as the parent who donates the nucleus, he or she will
in all likelihood enjoy the parent's state of health and will be free of the
additional risks caused by mixing both parents»
genes during sexual reproduction.
Additional examination of the two
genes in anoxeria - prone families gave the researchers a handle on which DNA sequence variations conferred the most risk.
The two families had distinct facial dysmorphic features that led Karaca to identify the
gene in three
additional families with very similar features.
Additional experiments, including
gene knockdown, surfaced prohibitin as a likely infection aide; prohibitin is a multi-functional protein found
in human cells and
in many other organisms.
In a second experiment, they used a different assay to look at an
additional 6000
genes.
Pandolfi and colleagues sought to identify an
additional tumor suppressing
gene or pathway that may work
in concert with PTEN to drive metastasis.
«We're confident that applying this same approach to a lot of new data will help us discover
additional genomic variations and identify specific
genes that play a role
in schizophrenia and other psychiatric conditions.»
Overall, the new study suggests that genetic variations
in the
gene that codes for POU6F2 may affect the structure of the eye and increase a person's risk of glaucoma, but
additional studies will be needed to describe the exact mechanism.
Thus we can conclude that mutations occurred
in the CDR3s during the protein immunization phase resulting
in neutralization ability, alongside
additional mutations
in the V
gene which are required for breadth at least
in the A14 / B9 lineage.