Receptor molecules coded by the 7 - repeat allele have been found to have a lower potency for dopamine - mediated coupling to
adenylate cyclase than receptors encoded by the other frequent, 2 - or 4 - repeat forms [90], and more recent results suggest an additional effect of the 48 bp VNTR on gene expression [91, 92].
The basic mechanism of action of forskolin is the activation of an enzyme,
adenylate cyclase, which increases energy levels in cells.1 These enzymes are perhaps the most important cell - regulating compounds.
Clary Sage extract - Clary sage is also known as Salvia Sclarea, which is a potent
adenylate cyclase activator - meaning that it increases the enzyme action of forming cylic AMP (cAMP - cyclic adenosine monophosphate) from ATP.
Activated heterotrimers have a wide array of effectors including
adenylate cyclase (AC), phospholipase C - beta, PI 3 - kinases, GIRK channels and RhoA
Called
adenylate cyclase 3 (ADCY3), the gene codes for a protein known to be related to appetite control and our sense of smell.
The effects of prior stress on anxiety - like responding to intra-BNST pituitary
adenylate cyclase activating polypeptide in male and female rats King SB, Lezak KR, O'Reilly M, Toufexis DJ, Falls WA, Braas K, May V, Hammack SE.
Pituitary
adenylate cyclase activating polypeptide (PACAP) signalling exerts chondrogenesis promoting and protecting effects: implication of calcineurin as a downstream target.
As a postdoctoral fellow, he worked with Nobel laureate Alfred Gilman, and purified and characterized the inhibitory component of
adenylate cyclase, Gi.
Studies of glutamate receptor channels expressed in cultured hippocampal pyramidal neurons reveal that these channels are subject to neuromodulatory regulation through
the adenylate cyclase cascade.
The whole - cell current response to glutamate and kainate [a non-NMDA (N - methyl - D - aspartate) receptor agonist] was enhanced by forskolin, an activator of
adenylate cyclase.
Desensitized beta - adrenergic receptors showed a 40 to 50 percent reduction in their ability to couple to the heterologous
adenylate cyclase system, comparable to the reduction in their functionality observed in their original membrane environment.
An adenylate cyclase that is activated specifically by very low concentrations of octopamine has been identified both in homogenates and in intact cells of the thoracic ganglia of an insect nervous system.
Molecular cloning of complementary DNA for the alpha subunit of the G protein that stimulates
adenylate cyclase
A complementary DNA clone encoding the alpha subunit of
the adenylate cyclase stimulatory G protein (Gs) was isolated and identified.
This enzyme appears to be distinct from two other
adenylate cyclases present in the same tissue, which are activated by dopamine and by 5 - hydroxytryptamine, respectively.
Dimerization of mammalian
adenylate cyclases.