Sentences with phrase «akt signaling cascade»

Previously in a mutated BRAF mouse model, ablation of PTEN led to melanoma development [45], suggesting the PI3K / AKT signaling cascade is one of the critical players in melanoma turmorigenesis.

The anti-apoptotic effect of BES was dependent on the activation of the PI3K / Akt signaling cascade and an increase in brain - derived neurotrophic factor (BDNF) production.

Not exact matches

[42 - 46] KIT, a type III transmembrane receptor tyrosine kinase that sits upstream of NRAS and BRAF, feeds into several signaling pathways, including both the RAS / RAF / MEK / ERK cascade and the PI3K / Akt / mTOR pathway.