Allelic exclusion of the TCR α - chain is an active process requiring TCR - mediated signaling and c - Cbl.
Kin Ritchie, Ralph Brinster, and Ursula Storb show that an IgL transgene inhibits rearrangement of endogenous IgL genes, providing the first clue for the mechanism of
allelic exclusion of Ig genes.
Not exact matches
Junji Hirota at Tokyo Tech and team focused on discovering a long - range enhancer for a large gene cluster, finding an evolutionary conserved sequence motif in mammalian evolution, and elucidating enhancer - dependent
allelic preference or
exclusion mechanism for odor - detecting receptor genes.