Sentences with phrase «allosteric modulator»

• Alfred J, Uberti M, Dovlatyan M, Li Z, Smith D, Weiss J, Jubian V, Grenon M, Li G, Doller D and Brodbeck R: The Synthesis and invitro pharmacology of the selective mGLUR5 negative allosteric modulator (NAM).

One particular focus in our work is structure, dynamics, and interactions of G - Protein Coupled Receptors (Wu, H.; et al. «Structure of a class C GPCR metabotropic glutamate receptor 1 bound to an allosteric modulator»; Science; 2014; 58 or Alexander, N.; et al. «Energetic analysis of the rhodopsin - G - protein complex links the alpha5 helix to GDP release»; Nat Struct Mol Biol; 2014; 56).

Administration of a positive allosteric modulator of the type 1 metabotropic glutamate receptors mGluR1 during the first postnatal week restored DA neuron excitatory synapse transmission and partially rescued the social preference defects, while optogenetic DA neuron stimulation was sufficient to enhance social preference.

Title: Selective Remediation of Reversal Learning Deficits in the Neurodevelopmental MAM Model of Schizophrenia by a Novel mGlu5 Positive Allosteric Modulator Author: F. Gastambide et al..

Identification of an antithrombotic allosteric modulator that acts through helix 8 of PAR1.

His work helped discover a class of molecules called core protein allosteric modulators, or CpAMs, that disrupt capsid protein assembly.

The project aims to discover new agonist, antagonist and allosteric modulators of these receptors mostly orphans.

With Jan Stichel at Annette Beck - Sickinger's lab, Leipzig University, Germany and David Weaver, head of the high - throughput screening facilities at Vanderbilt University, I will be screening Vanderbilt's library of small molecules for potential allosteric modulators of the human Y4 receptor.

In a departure from traditional drugs that «turn on» or «turn off» neurotransmitter receptors, Conn, Lindsley and their colleagues have developed compounds called «allosteric modulators» that can «tune» receptors like dimmer switches in an electrical circuit.

Muscarinic receptor M4 positive allosteric modulators attenuate central effects of cocaine...

The PI of the proposal has also experience in cheminformatics method development for chemical biology and therapeutic development (Mueller, R., et al.; «Discovery of 2 -(2 - Benzoxazoyl amino)-4-Aryl-5-Cyanopyrimidine as Negative Allosteric Modulators (NAMs) of Metabotropic Glutamate Receptor 5 (mGlu5): From an Artificial Neural Network Virtual Screen to an In Vivo Tool Compound»; ChemMedChem; 2012; 7; 406).

The findings indicate that compounds known as positive allosteric modulators, or PAMS, can increase the natural pain - relief chemicals produced by the body in response to injury.