Sentences with phrase «also significant alterations»

Not exact matches

In 2005, the identification of an activating mutation in JAK2 (the V617F mutation) as a STAT5 - activating and disease - causing genetic alteration in a significant proportion of patients with myeloproliferative neoplasms (MPNs) has emphasized the oncogenic role of the JAK tyrosine kinases in hematologic malignancies.2 — 5 JAK2 is a member of the Janus tyrosine kinase family comprising three other mammalian non-receptor tyrosine kinases (JAK1, JAK3 and TYK2) that associate with cytokine receptors lacking intrinsic kinase activity to mediate cytokine - induced signal transduction and activation of STAT transcription factors.6 All JAKs share a similar protein structure and contain a tyrosine kinase domain at the C - terminus flanked by a catalytically inactive pseudokinase domain with kinase - regulatory activity, by an atypical SH2 domain and by a FERM domain that mediates association to the membrane - proximal region of the cytokine receptors.7, 8 Soon after the discovery of JAK2 V617F, we and others described that activating JAK1 mutations are relatively common in adult patients with T - cell acute lymphoblastic leukemia (ALL) and participate in ALL development allowing for constitutive activation of STAT5.9 — 11 Several STAT5 - activating JAK1 mutations were also reported in AML and breast cancer patients.10

About 90 % of solid tumors display whole - chromosome aneuploidy, while many tumors with diploid karyotypes nonetheless harbor segmental or arm - length aneuploidies that also result in significant gene copy number alterations.

Over the course of this third solo outing for the god of thunder, Thor will lose his allies, his freedom, those flowing golden locks, and also something more permanent, but none of these will be the most significant alteration to the character in Taika Waititi's zippy, slightly tilted, often joyfully frenzied film: Thor is finally in on his own joke.

A number of alterations under the hood should mean performance also sees a significant boost.

In addition to policy alterations and discounts, switching insurance providers may also lead to significant savings for homeowners in Idaho.

Validation for preschool MDD (based on meeting all DSM - IV symptom criteria) has been supported by the finding of a specific symptom constellation that was distinct from other psychiatric disorders and stable during a 6 - month period.22 Additionally, alterations in the hypothalamic - pituitary - adrenal axis reactivity similar to those known in adults with depression, greater family history of mood disorders, as well as observational evidence of depressive affects and behaviors were detected in preschoolers with depression, providing further validation.22,25,27 - 30 More recent findings from a larger independent sample (N = 306) ascertained from community sites (and serving as the population for this investigation) have replicated the findings described above and have also demonstrated that preschoolers with depression display significant functional impairment evident in multiple contexts rated by both parents and teachers.24

You must also prove the significant change and alteration to the custody order is in the child's best interests.