Sentences with phrase «alters cell phenotype»
Neonatal Inhibition of DNA Methylation Alters Cell Phenotype in Sexually Dimorphic Regions of the Mouse Brain Endocrinology April 7, 2017 Morgan Mosley, Jill Weathington, Laura R. Cortes, Emily Bruggeman, Alexandra Castillo - Ruiz, Bingzhong Xue, and Nancy G. Forger Many of the best - studied neural sex differences relate to differences in cell number and are due to the hormonal control of developmental cell death.
https://www.endocrine.org/ Not exact matches
Previously, True and Whitehead Institute Director Susan Lindquist reported that a particular yeast protein called Sup35 somehow altered the metabolic properties — or phenotype — of the cell when it «misfolded» into a prion state.
Masters et al. discuss the often overlooked contribution of the stromal microenvironment as an extrinsic factor to immunosenescence and inflammation.12 Accumulation of senescent stromal cells which demonstrate the senescent associated secretory phenotype (SAPS), may alter tissue structure and function, and increase local inflammation.13 The impact of altered lymphoid stromal microenvironment may be widespread and include altered haematopoiesis, reduced lymphatic flow and disrupted secondary lymphoid organisation, which consequently will alter antigen transportation and presentation to T cells.12
More recent work by Aggarwal and Pittenger 82 supported the feasibility of MSC - transplantation showing that MSC altered the phenotypes of specific immune cell subtypes thereby creating a tolerogenic environment.
Clonal persistent patients harbored a larger number of residual tumor cells with genotypes and phenotypes that were altered in response to NAC.»
Melanocytes respond by altering gene transcription, and these changes in gene expression profiles result in easily quantifiable phenotypes such as modified pigment production (a hallmark of melanocyte differentiation state) and changes in morphological cell properties.
It was discovered that CMV was the prime driving force behind most of the oligoclonal expansions and altered phenotypes and functions of CD8 cells.
The scientific goal of the Cancer Biology Program is to identify novel genomic and genetic alterations that play causal roles in cancer development and to study genes, proteins, and signaling pathways that mediate the altered phenotypes of cancer cells.
Cellular senescence is the irreversible growth arrest of individual mitotic cells, which as a consequence display a radically altered phenotype that is thought to impair tissue function and predispose tissues to disease development and / or progression as they gradually accumulate.
It has now become clear that CMV is commonly the driving force behind the oligoclonal expansions and altered phenotypes and functions of CD8 cells seen in most old people.
Phenotypic screening is used routinely in drug discovery for the identification of substances that alter the phenotype of a cell or an organism.