Sentences with phrase «amrose subclones»

But tumors from patients with distant metastases to the lung and liver showed massive epigenetic changes that mapped to large, blocklike segments of the genome, both in the distant metastases themselves and in the section, or «subclone,» of the primary tumors they came from.

Prof Tony Green, an author from the Wellcome Trust - MRC Stem Cell Institute and Cambridge University, said: «The SC3 tool was able to use patterns of gene expression to distinguish, within an individual cancer, subclones that carried different mutations.

The discovery was made by developing a mouse model of the disease that enabled researchers to track which of 15 genetic groups — or subclones — of myeloma cells spread beyond their initial site in the animals» hind legs.

By labeling the different subgroups with fluorescent dyes, researchers determined that just one of the subclones was responsible for the disease metastasis.

Subclones with the best evolutionary fitness will, in time, come to dominate the population.

The mammary tumors frequently contained two distinct subclones — one produced Wnt1 while the other did not.

Thus even the rare subclones carry driver mutations that contribute to cancer cell survival.

Yet there were numerous different subclone haplotype — one came to dominate, but the others persisted as well.

We see extensive variability in genomes among tumours of different tissue types, among different patients within a tissue type and among subclones within a given patient's cancer.

AK - dCK - subclone of AA cells.

Subclone of A3.01 producing low levels of RT and p24.

«No single subclone seems to be capable of gaining the upper hand, leading us to wonder whether subclones might be working together in some instances.

Cancers contain genetically different subpopulations of cells, called subclones.

However, in some cases it seems that no single subclone can achieve dominance on its own.

Subclone of A3.01, a CD4 + CEM derived human T - cell line.

Thus, two subclones of the tumor in AML35 both acquired activating mutations of IDH2 at the same residue but by different mutations.

These findings reinforce many things that we already know: that mutations acquire gradually with age, that most of the mutations in AML (and likely other tumors) are random background events not contributing to tumorigenesis, and that subsequent mutation and evolution can give rise to subclones that ultimately determine cancer progression and response to therapy.

In all 7 cases, the results suggest a linear model of clonal evolution, in which progression from MDS to sAML was characterized by persistence of a single founder clone (defined by ~ 200 - 700 mutations) and the outgrowth of at least one new subclone which contained dozens or hundreds of additional mutations.

Cells from the founding clone sometimes acquired additional cooperating mutations (e.g. FLT3), yielding subclones that may have contributed to progression or relapse.

We developed and implemented such a nomenclature for the European human pluripotent stem cell registry (hPSCreg), which needs to: 1) unambiguously identify a registered cell line; 2) allow tracing of subclones of a particular line; and 3) enable the assignment of different lines to a specific donor origin.

As sensitive as it is, it still allows some variants, and thus some subclones, to fly under the radar.

Whether identifying rare subclones missed by standard bulk sequencing, or identifying co-mutation patterns in subclones, Tapestri Single - Cell DNA Panels can be applied across a wide number of applications, including hematologic malignancies, solid tumor profiling, and genome editing programs.

Many doctors had long believed that leukemia was a relatively simple disease typically involving just one «subclone,» or cancer genome.

One of the subclones had lurked in her bone marrow at low levels until the first round of chemotherapy treatment wiped out the others.

Then, the remaining subclone acquired new mutations and took the others» place, dooming the patient to relapse.

It could also help in the clinic by indicating combinations of drugs or other treatments that offer a better chance of killing all present subclones, either in one shot or over time.

These «tumor subclones» are often very relevant as the tumor evolves (especially during treatment).

The subclones were tested in normal CM and CM containing 0.5 µg / ml mycophenolic acid for their sensitivity to this drug.

We demonstrate that SC3 is capable of identifying subclones from the transcriptomes of neoplastic cells collected from patients.

These clonal expansions can lead to several coexisting subclones sharing subsets of mutations.

Crude genomic DNA extracts (gDNA) of 78 AID - negative Amrose subclones were prepared by incubation of cell pellets of app.

Careful examination of primary breast cancers often reveals multiple genomically distinct subclones that may contain driver alterations that follow spatial patterns of segregation.

The majority (but not all) of the BayGenomics ES cell lines were generated from 129P2 / OlaHsd (formerly 129 / Ola) ES cell lines, predominantly the E14Tg2A.4 parental subclone.