Sentences with phrase «analysis in large cohorts»

Saturday, Oct. 21, 9:45 - 10:45 a.m., Room 330A, South Building Platform Session: Advancing Drug Discovery by Genetic Analysis in Large Cohorts Moderator: Dana Crawford, Case Western Reserve University

In the first study (Klaassen et al., 2008) mutational analysis in a large cohort of 63 unrelated adult probands with LVNC and absence of other congenital heart anomalies was performed.

Not exact matches

Most studies of homebirth in other countries have found no statistically significant differences in perinatal outcomes between home and hospital births for women at low risk of complications.36, 37,39 However, a recent study in the United States showed poorer neonatal outcomes for births occurring at home or in birth centres.40 A meta - analysis in the same year demonstrated higher perinatal mortality associated with homebirth41 but has been strongly criticised on methodological grounds.5, 42 The Birthplace in England study, 43 the largest prospective cohort study on place of birth for women at low risk of complications, analysed a composite outcome, which included stillbirth and early neonatal death among other serious morbidity.

An UpToDate review on «Planned home birth» (Declercq and Stotland, 2015) stated that «Large cohort studies using intent - to - treat analysis of midwife - attended, planned, out - of - hospital birth of low - risk women in developed countries have reported reduced rates of cesarean birth, perineal lacerations, and medical interventions, and similar rates of maternal and early perinatal morbidity and mortality compared to planned hospital birth.

Together, the results of the well - controlled observational studies20 - 23 (including ours), the analysis of cohorts without social patterning of breastfeeding (eg, in the Pelotas cohort), 24 and the large randomized trial25 suggest that confounding does not account fully for the observed association of breastfeeding with later cognition.

The Chronic Hepatitis Cohort Study is an analysis of records from a large, geographically and racially diverse group of 9,783 patients receiving care at four large U.S. health systems: Henry Ford Health System in Detroit; Kaiser Permanente Northwest in Portland, Oregon; Kaiser Permanente in Honolulu and Geisinger Health System in Danville, Pennsylvania.

«Our analysis of three large U.S. cohorts including persons in whom diabetes has been diagnosed shows those who were at target levels for HbA1c, blood pressure and LDL to have substantially lower risks for cardiovascular disease than persons with diabetes who were not at target levels for such factors,» Wong said.

Researchers expect the data presented in this study to fuel the formation of large national and international research consortiums to conduct comprehensive, systematic analysis of inherited (germline) genome data in large cohorts of uveal melanoma patients.

The Columbia researchers with colleagues in Finland conducted an analysis of data from the Finnish Prenatal Study of Schizophrenia, a large, national birth cohort with an extensive bio-bank.

Dr. Polonis» lab has focused for many years on functional antibodies elicited by natural infection and by vaccination, utilizing samples from multiple natural history cohorts and vaccine studies; her lab is currently performing an extensive analysis of pseudovirus neutralizing antibodies in the large RV144 follow - on trial, RV306.

It allows the analysis of host immune gene expression in relation to vaccination, infection, disease or therapy in larger cohorts.

As recently shown in a collaborative analysis of 10 large cohort studies, women appear to feature more often the metabolically healthy obese phenotype with normoglycemia and without dyslipidemia and hypertension (7 % — 28 %) compared with males (2 % — 19 %)(39).

The prevalence of metabolic syndrome and metabolically healthy obesity in Europe: a collaborative analysis of ten large cohort studies

Since 1997, he has directed the investigation of neurodegenerative diseases in the Nurses» Health Study and other large cohorts comprising more than 400,000 men and women who have provided detailed information on their dietary habits and lifestyle in addition to blood or cheek cell samples for genetic and other laboratory analyses.

For meaningful scientific interpretation of histopathological data through analysis of large cohorts of mice, we recommend, 24 mice per age group (i.e., number used in systematic clinical tests).

Analysis of larger cohorts will provide information about the frequency and kinetics of PARPi reversion mutations in this patient population.

BLASTing the 15 - bp PORE sequence revealed a large cohort of genes potentially regulated by such a mechanism (although osteopontin, the one target gene previously known to be regulated by a PORE sequence, was not identified in this analysis).

Our bioinformatics analysis, based on multiple independent large - size cohorts shows that MELK is strongly overexpessed in BBC / TNBC, not only compared to normal breast tissues, but also compared to luminal or ER / PR + breast cancer.

However, the point estimates suggest that prebiotic consumption, especially GOSs, might be associated with a lower risk of depression; therefore, it would be of great interest to replicate these analyses in a cohort with a larger number of incident cases of depression to increase the statistical power.

«His meta - analysis of the cutting - edge research on large - cohort studies of what sugar does to populations across the world, alongside his own clinical observations, has him credited with starting the war on sugar,» writes Zoe William in The Guardian.

Analyses were conducted using public - use data available from the Fragile Families and Child Wellbeing Study, a prospective birth cohort study that follows up a nationally representative sample of children from 20 large cities in the United States.