Sentences with phrase «animal models also»

Animal models also suggest that early adversity has a negative impact on the development of prefrontal cortex - based cognitive functions.

Animal models also help, but cancers in research animals such as mice are different from those in humans.

Animal models also can help at earlier steps in the creation of new medicines.

Not exact matches

Holiday Magic also includes singing to the animals, a model railroad display, photo opportunities with animals, professional ice - carving demonstrations and a 41 - foot talking tree.

In animal models, exposure to cigarette smoke or nicotine during fetal development alters the expression of the nicotinic acetylcholine receptor in areas of the brainstem important for autonomic function, 28 alters the neuronal excitability of neurons in the nucleus tractus solitarius (a brainstem region important for sensory integration), 29 and alters fetal autonomic activity and medullary neurotransmitter receptors.30 In human infants, there are strong associations between nicotinic acetylcholine receptor and serotonin receptors in the brainstem during development.31 Prenatal exposure to tobacco smoke attenuates recovery from hypoxia in preterm infants, 32 decreases heart rate variability in preterm33 and term34 infants, and abolishes the normal relationship between heart rate and gestational age at birth.33 Moreover, infants of smoking mothers exhibit impaired arousal patterns to trigeminal stimulation in proportion to urinary cotinine levels.35 It is important to note also that prenatal exposure to tobacco smoke alters the normal programming of cardiovascular reflexes such that there is a greater - than - expected increase in blood pressure and heart rate in response to breathing 4 % carbon dioxide or a 60 ° head - up tilt.36 These changes in autonomic function, arousal, and cardiovascular reflexes might all increase an infant's vulnerability to SIDS.

This week in Nature Communications, an interdisciplinary team of scientists proposes a more nuanced model for extinction that also shows why animal species tend to evolve toward larger body sizes.

These findings allowed researchers to create a chimera virus: a mouse virus with a human viral gene that can be used to test molecules that inhibit human LANA protein in an animal model of disease, treating not only human herpes virus infection but also its associated cancers.

Scientists at Duke Health who developed the new model also discovered that targeting a brain receptor in mice with this type of autism could ease repetitive behaviors and improve learning in some animals.

The laboratories also collaborated to successfully prove that reversing a protein deficiency through gene therapy is effective in improving and stabilizing SMA in a large animal model.

In addition to discovering this mechanism, Yong and Sarkar also identified a drug — amphotericin B (AmpB)-- to reactivate microglia that in an animal model, showed a significant reduction in brain tumor growth.

They also studied animal models of LUAD to identify common pathways.

«Immune molecule protects against Zika virus infection in animal models: Molecule also protects against Zika - induced microcephaly in mouse model.»

But the models also indicated that the birds» coordination would have to be exceptionally precise to make a difference, and many scientists had doubted that the animals could achieve such a feat during flight, says ecophysiologist Steven Portugal at the Royal Veterinary College in Hatfield, UK.

Nadeau also studies the potential impacts of climate change on species around the globe, using modeling, field observation and experiments to predict where species are most vulnerable and determine how conservation groups can best mitigate the negative impacts of climate change on animal populations.

He and his colleagues are also attempting to make an animal model of stuttering by inserting the human mutation into mice.

He also wants to test his system in vivo in animal models.

In an animal model, they demonstrated for the first time that two proteins designed by the researchers not only recover muscle force and increase body weight in the sick animals but also significantly prolong survival.

They also stopped making new brain cells, something that has also been seen in other animal models of depression.

Young scientists trying to establish new animal models are also trying to establish their careers.

Harding also argues that because rodent studies suggest that these animals do lose neurons to alcohol, they may be unreliable models for the human hippocampus.

The brochures contain information about toxicology, pharmacology, and animal safety studies used to determine the potential risk a particular therapy may pose to humans, but they also include efficacy studies done in animal models to demonstrate a therapy's potential benefit.

And several attempts to carve a new target from a family of enzymes called p38 kinases have also failed, despite favorable results in animal models.

And by providing an animal model for the fetal damage, the studies should also ease the path for testing potential vaccines and treatments.

Two of them also prove for the first time in an animal model that Zika virus can cause microcephaly in fetuses.

Dr. Zhuo's team also found a novel molecule, called NB001, which can specifically block neuronal pre-LTP, and has powerful analgesic, or pain - reducing, effects in animal models of chronic pain.

Interestingly, increased activity in the ACC is also seen in humans suffering from anxiety disorders and in animal models of anxiety.

Studying vision in autism may also help connect studies of people to those of animal models.

With this in mind, he and Amit Kapoor, also at Columbia, set out to find a smaller animal that could serve as a model for hepatitis C.

The researchers now plan to test this type of insulin in other animal models and are also working on tweaking the chemical composition of the insulin to make it even more responsive to blood - glucose levels.

The star - shaped peptide polymer is also effective in killing superbugs when tested in animal models.

However, it was unclear at this stage in their research if this was a species - specific finding limited to animal tumor models or if this was a biologic phenomenon that may also be present in cancer patients.

Importantly, these devices also will open up new approaches to drug development not possible with animal models today, such as personalized medicines and development of therapeutics for specific genetic subpopulations using chips created using cells from particular patients.»

Signs of neuronal damage around plaques also varied depending on the APOE variant the animals received, and experiments in a different Alzheimer's model in which plaques appear more slowly showed that injection of APOE4 increased levels of free, soluble A-beta in the fluid that bathes the brain.

Yong, a neuroscientist, initially had the idea to test the acne medicine in an animal model since minocycline has many anti-inflammatory properties that he thought could be useful in treating MS. Soon after obtaining successful research results, in studies also supported by the MS Society of Canada and MSSRF, Yong teamed up with Metz who led the transition into a pilot clinical trial, then a Phase 2, and finally the definitive Phase 3 trial.

«It has the potential to inform clinical practice and also guides us about the relevance of animal models of human disease and how we can reduce and refine their use.»

«There's a lot of literature that points to chondrodystrophy in dogs as an exciting animal model for degenerative disc disease in people,» said Bannasch, who also holds the Maxine Adler Endowed Chair in Genetics.

«In animal models,» Lee explains, «the question we want to ask is, can we reduce the pathology and also rescue cell loss to improve the behavioral deficits?»

This dosing also exceeded the predicted human efficacious dose for AVI - 7288 estimated by three different models based upon the nonhuman primate studies that demonstrated up to 100 percent animal survival, including a delayed time - to - treat setting.

(At the other extreme, animals such as horses, who have a long gestation and then walk almost immediately after they are born, also fit the model.)

Genetics is also important for understanding how research scales up — or fails to — and translates from animal models to humans and among different human populations, says Henry Bryant, a research fellow at Lilly Research Laboratories in Indianapolis.

Recent work by the same group of researchers showed that such disruptions in sleep were also a hallmark of fetal alcohol syndrome, both in animal models and in people.

Although there are animal models of TB infection, results can be slow to emerge and also can be costly.

The nanoparticles were also tested in vivo in animal models, and separately in mathematical models.

We also want to use this system to explore which substances could counteract the progress of neurodegeneration in the brain without having to use animal models at this early stage.

Ford has also found that neuregulin — at least in animal models — can prevent atherosclerotic plaque development, possibly because both conditions may share similar molecular mechanisms.

The lack of an animal model has also prevented scientists from testing and fine - tuning experimental therapies for people.

Also, research in other animal models, such as rodents, has shown anesthesia exposure early in life can lead to cell death in the brain and cognitive impairments.

You can also learn about the real - world plant and animal life that inspired Avatar's fictional flora and fauna, peer inside the Armored Mobility Platform suit that was used in combat scenes, and examine the filmmakers» models of Na» vi characters and their costumes.

Animal models and clinical trials have shown that antioxidants and anti-inflammatory drugs could not only reduce symptoms associated with the disorders but also prevent the appearance of neurobiological abnormalities and transition to psychosis if given early during brain development.

The engineered T cells also performed successfully in a mouse model of PV, killing desmoglein - specific B cells and preventing blistering and other manifestations of autoimmunity in the animals.