I became an eye researcher completely by accident while trying to unravel the role of a protein called
Ankyrin in forming biological important membrane domains in cells, in this case, the photoreceptor.
Not exact matches
In collaboration with Dr. Ke Xu's lab at UC Berkeley, the team determined that this is because of aberrant accumulation and distribution of Ankyrin - G in the AI
In collaboration with Dr. Ke Xu's lab at UC Berkeley, the team determined that this is because of aberrant accumulation and distribution of
Ankyrin - G
in the AI
in the AIS.
The sequence similarity between MAD - 3 and pp40 includes a casein kinase II and consensus tyrosine phosphorylation site, as well as five repeats of a sequence found
in the human erythrocyte protein
ankyrin.
Like
ankyrins, tankyrase contains 24
ankyrin repeats
in a domain responsible for its interaction with TRF1.
In baseline tests, the high - energy
ankyrin - G mice usually swam longer, only floating for about 10 seconds of the 200 second test compared to the normal mice that floated about 50 seconds, but after several sessions with the bully mice, the
ankyrin - G mice were quick to give up and float, remaining still for well over 100 seconds on average.
Specifically, the mice lacked the protein
ankyrin - G,
in particular neurons
in the brain, a defect that appears to make the animals both hyperactive and less fearful, a behavioral profile suggestive of a mania - like state for a mouse.
To see what was happening
in the brains of these
ankyrin - G mutant mice, the researchers analyzed the cell components
in inhibitory synapses connecting with pyramidal neurons, finding that two proteins known as GAT1 and GAD67 — responsible for making the neurochemical GABA that dials back nerve impulses — were at much lower levels
in the synapses on pyramidal neurons
in ankyrin - G mutant mice than
in normal mice.
The membrane associated adaptor
ankyrin - B (AnkB) promotes fast axonal transport and elongation by coupling dynactin to multiple organelles through binding to phosphatidylinositol 3 - phosphate lipids
in these cargos.
Here we show variation between incompatible Culex strains
in two Wolbachia
ankyrin repeat - encoding genes associated with a prophage region, one of which is sex - specifically expressed
in some strains, and also a direct effect of the host nuclear genome on CI rescue.
There are also many other differences
in the number or coding sequences of
ankyrin repeat genes between wMel strain genomes and wAu [21], [49](see also [15] and [48] for sequence of wMelCS).
Several putative transcripts with homology to chitinase and chitinodextrinase were upregulated
in future ocean conditions, as well as two putative transcripts with homology to
ankyrins, and one transcript with homology to an ABC transporter solute - binding protein (see electronic supplementary material, table S5).
Transient Receptor Potential
Ankyrin 1 Ion Channel Facilitates Acute Inflammation Induced by Surgical Incision
in Mice