Sentences with phrase «anti-alpha tubulin»

To determine whether SIV infection leads to corneal nerve fiber loss, the researchers immunostained corneas for the nerve fiber marker βIII tubulin.

This unique organization of tubulin is preserved among all living plant and animal cells, because it is essential for way in which microtubules assemble, Al - Bassam said.

Microtubules are hollow cylinders with walls made up of tubulin proteins — alpha (green) and beta (blue)-- plus EB proteins (orange) that can either stabilize or destabilize the structure of the tubulin proteins.

Then they put all six genes into a single piece of DNA, so that they would all be transcribed together — and found that they could reconstitute the «3 - D printer» that assemble tubulin dimers.

Al - Bassam said the results open up new ways of thinking about tubulin, tubulin - related disorders and molecular biology in general.

Jawdat Al - Bassam at the UC Davis Department of Molecular and Cellular Biology and colleagues have now taken a close look at the proteins that assemble tubulin, and found that they comprise a single machine, not a stepped pathway as previously thought.

For example, formation of the mitotic spindle significantly depletes the numbers of free tubulin molecules in the soluble phase of the cytoplasm.

Which of these becomes dominant depends on the relative concentrations of the tubulins and the motor proteins: In a certain concentration range the dynamic equilibrium between growth and shrinkage of the microtubules operates as it would if resources were not limiting.

The energy maybe required to build stable alpha and beta tubulin assembly.

In this situation, the microtubules continue to grow until the concentration of tubulins falls below a critical value.

Building from two subunits, alpha and beta tubulin, this protein assembles into microtubules that play a vital role inside cells — giving structure, pushing or pulling other things around, or providing a track on which other molecules can pull themselves along.

Even small defects in the genes that assemble tubulin are associated with serious developmental disorders, such as Kenny - Caffey syndrome and Giant Axonal Neuropathy.

Microtubules, hollow fibers of tubulin protein only a few nanometers in diameter, form the cytoskeletons of living cells and play a crucial role in cell division (mitosis) through their ability to undergo rapid growth and shrinkage, a property called «dynamic instability.»

Assembling alpha - beta tubulin dimers involves six known genes, Al - Bassam said.

When a kinesin protein reaches the end, it detaches from the filament taking the tubulin to which it is bound with it.

GTPase activity — coupled treadmilling of the bacterial tubulin FtsZ organizes septal cell wall synthesis.

They added a tubulin - binding protein known as Tau, that connects the HyPer protein to the microtubule structures.

The NIMS group used nanotechnology to study conductive properties of individual microtubules, protein polymers of tubulin (the brain's most prevalent protein).

Tubulin is labeled gold, highlighting the cell body and flagellum, while the protein actin is labeled blue, showing off the organism's distinctive collar.

Tubulin, a flexible protein, assembles into a long chain to create microtubules.

Things like HIV protease inhibitors, for example, or Kinesin - tubulin interactions do not appear to be covered by any of the subheads listed under these two headings.

To test the memristor theory, Tuszynski's team filled a dish with microtubules, tubulin proteins and a buffer solution, then added electricity.

Like the family of taxanes (of which paclitaxel is a member), epothilones prevent cancer cells from dividing by interfering with tubulin proteins that form the cells» skeletal microtubules.

This cytoskeleton is largely made from the tubulin proteins that form microtubule filaments.

His team discovered that tubulin proteins were among them, and then found that if a kind of reverse agent were administered — a microtubule - stabilizing drug — so were the anesthetic effects.

She adds that her team is finding more than collagen: It has recovered sequences from eight proteins isolated from what appear to be blood vessels, all matching common vessel proteins such as actin, tubulin, and hemoglobin.

Tubulin and tubulin - like proteins are highly conserved evolutionarily, found in some bacteria, fungi, higher plants, and animals.

Top: Fruit fly cells showing the endoplasmic reticulum (blue), nucleus (red) and tubulin (green).

The challenge was getting SiR to bind specifically to the cytoskeleton's proteins, actin and tubulin.

To achieve this, the scientists fused SiR molecules with compounds that bind tubulin or actin.

It consists of three major sub-structures inside the cell, which are made up of long, filamentous proteins: tubulin and actin.

One such compound was docetaxel, an anticancer drug that binds tubulin, and the other jasplakinolide, which specifically binds the cytoskeletal form of actin.

Microtubule strands assemble from subunits of alpha and beta tubulin proteins that form dimers.

Beta tubulins can selectively (and reversibly) allow GTP to hydrolyze; they take on water to become guanosine diphosphate (GDP).

These findings add to the growing understanding of the «tubulin code» — a phenomenon where TTLL7 and similar proteins add amino acids to microtubules and prompt them to fast - track certain proteins for transport.

It's also the first structure determined of any ligase in the tubulin tyrosine ligase - like (TTLL) family.

One possibility is that it acts directly to enhance the polymerization of tubulin and actin, the monomeric proteins that give rise respectively to microtubules and micro filaments.

Most importantly, they found that the active site of TTLL7 is ideally positioned to contact the negatively charged «beta - tail» of beta - tubulin, one of the two protein building blocks of the microtubule polymer (alpha - and beta - tubulin).

The reason for the rapid development of resistance was that these fungicides were single site inhibitors of fungal microtubule assembly during mitosis, via tubulin - benzimidazole - interactions.

AHERF Neurosciences Grant (G9410 -020-Y01)- Co-PI; «Differential expression and sorting of the neuron - specific class III b - tubulin isotype in human neuronal and neuroendocrine tumor cell lines maintained in an organ culture system».

In the center, FGFR - TACC fusion protein (red) can be seen disrupting tubulin bundles (green), structures that support cell division, or mitosis, at the point connecting the two daughter cells (whose nuclei are colored blue).

We observed a modest decrease in cell cycling and some induction of the neuronal marker beta - III tubulin, as quantified here.

Tubulin - mediated binding of human immunodeficiency virus - 1 Tat to the cytoskeleton causes proteasomal - dependent degradation of microtubule - associated protein 2 and neuronal damage.

In vivo analysis of the functions of γ - tubulin - complex proteins.

This finding is consistent with the recent discovery with several «eukaryotic» signature genes in these archaeal lineages, including genes encoding proteins such as actin, tubulin, and several proteins involved in transcription and membrane deformation.

The Angiotensin II Type 1 Receptor C - Terminal Lys Residues Interact with Tubulin and Modulate Receptor Export Trafficking.

Here, FGFR - TACC (shown in red) can be seen interacting with tubulin bundles (green), structures that support mitosis, at the point connecting the two daughter cells (whose nuclei are colored blue).

One reaction serves as a positive control to amplify a portion of the tubulin gene found in all plants, and the other assays for genetic modification.

EGF - induced sodium influx regulates EGFR trafficking through HDAC6 and tubulin acetylation.

Chromosome segregation in fission yeast with mutations in the tubulin folding cofactor D. Current genetics, 50 (5), 281 — 294.