Sentences with phrase «apolipoprotein e»

A multilevel analysis of the influence of Apolipoprotein E genotypes on depressive symptoms in late - life moderated by the environment

The apolipoprotein E ε4 allele was associated with Alzheimer's disease in white but not in African - American or Hispanic people

Review: apolipoprotein E ε4 allele is a risk factor for Alzheimer's disease in different ethnic groups

Is There an Association between Temperament and Apolipoprotein E?

Proteomic analysis of plasma from California sea lions (Zalophus californianus) reveals apolipoprotein E as a candidate biomarker of chronic domoic acid toxicosis.

Associations of egg and cholesterol intakes with carotid intima - media thickness and risk of incident coronary artery disease according to apolipoprotein E phenotype in men: the Kuopio Ischaemic Heart Disease Risk Factor Study.

In a small study published online in the journal JAMA Neurology, June 2013, researchers found that dietary saturated fat cut the body's levels of the chemical apolipoprotein E, also called ApoE, which helps «chaperone» amyloid beta proteins out of the brain.

Apo E genes influence heart disease risk providing instruction for making a protein called apolipoprotein E.

Dietary omega 3 polyunsaturated fatty acids and Alzheimer's disease: interaction with apolipoprotein E genotype.

Increased amyloid β - peptide deposition in cerebral cortex as a consequence of apolipoprotein E genotype in late - onset Alzheimer disease.

The two most striking risk factors appear to be hyperinsulinism and possession of one or two E4 alleles for the apolipoprotein E gene (ApoE4), which is involved in lipid processing.

Cerebrospinal fluid and plasma insulin levels in Alzheimer's disease — relationship to severity of dementia and apolipoprotein E genotype.

Lane R and Farlow M. Lipid homeostasis and apolipoprotein E in the development and progression of Alzheimer's disease.

ApoE stands for Apolipoprotein E, which is a protein that transports fats and cholesterol in the body.

The investigators also found that eating one or more fish meals a week was linked to less Alzheimer's damage in the brain, but only among people with a gene variant called apolipoprotein E (APOE).

Keywords: Alzheimer's disease, apolipoprotein E ɛ4, boundary shift integral, brain atrophy, J - ADNI, sample size

Background Apolipoprotein E (APOE) is the most statistically significant genetic risk factor for late - onset Alzheimer disease (LOAD).

Apolipoprotein E, gender, and Alzheimer's disease: an overlooked, but potent and promising interaction.

Keywords: Alzheimer's disease, Apolipoprotein - A1, Apolipoprotein E, mild cognitive impairment, subjective cognitive decline

The interest intensified several years ago with the surprising discovery that an increased risk of Alzheimer's disease was linked to a natural genetic variant of a key fat - transporter molecule called apolipoprotein E, or apoE.

Defective Lipid Delivery Modulates Glucose Tolerance and Metabolic Response to Diet in Apolipoprotein E — Deficient Mice.

The aim of this study was to investigate the role of serotonin in depression, searching for association of two serotoninergic polymorphisms (T102C of serotonin receptor 5 - HT2A and serotonin transporter linked polymorphic region -5-HTTLPR - of SLC6A4 gene) with depressive symptoms and considering their possible interactions with Apolipoprotein E

The aim of this study was to investigate the role of serotonin in depression, searching for association of two serotoninergic polymorphisms (T102C of serotonin receptor 5 - HT2A and serotonin transporter linked polymorphic region -5-HTTLPR - of SLC6A4 gene) with depressive symptoms and considering their possible interactions with Apolipoprotein E... (ApoE) and between themselves, in a sample of 208 sporadic AD patients and 116 normal controls from Italy.

A specific type of brain activity important for memory replay is disrupted in mice with the E4 version of the apolipoprotein E (apoE4) gene, which may interfere with memory formation.

The editors of JLR will pay close attention to the Spotlight Talks, as the journal is just wrapping up an eight - review series on the major risk factor for Alzheimer's disease, apolipoprotein E, and it's time to get inspired for the next one.

Keywords: Alzheimer disease, antioxidants, apolipoprotein E, oxidative stress, presenilin, s - adenosylmethionine

Understanding the Role of Apolipoprotein E in Microglia Edoardo Marcora, PhD Icahn School of Medicine at Mount Sinai (New York, NY)

DONG ET AL.The allele apolipoprotein E ε4 (APOE ε4) is the greatest genetic risk factor for Alzheimer's disease (AD), but the role of the ApoE4 protein in AD has long been elusive.

Human genetic studies strongly point to apolipoprotein E (APOE) and microglia (the immune cells of the brain) as, respectively, the most important gene and cell type in the chain of events leading to Alzheimer's disease (AD), a common disorder in the elderly in which the brain is damaged and memories falter.

The goal of this project is to elucidate the functional role of apolipoprotein E (APOE) in microglia, the resident immune cells of the brain.

Protein C supports platelet binding and activation under flow: role of glycoprotein Ib and apolipoprotein E receptor 2.

There are four know AD genes: (1) Amyloid precursor protein gene (APP); (2) Presenilin 1 gene (PSEN1); (3) Presenilin 2 gene (PSEN2); (4) Apolipoprotein E gene (APOE).

The gene encodes a protein called apolipoprotein E.

Expression of apolipoprotein E mRNA in the epithelium and interstitium of the testis and the epididymis.

Walker said that the effect of one standard deviation increase in the overall inflammation score in mid-life on brain volume decades later was similar to the effect associated with having one copy of the apolipoprotein E (APOE) e4 gene that increases the risk of Alzheimer's disease.

Transplanted hearts lasted in four groups of mice as follows: • 21 days: mice with hyperlipidemia caused by a genetic mutation of apolipoprotein E (ApoE) placed on a high - fat diet • 51 days: healthy mice placed on a high - fat diet leading to hyperlipidemia • 61 days: mice with hyperlipidemia caused by a genetic mutation of ApoE on a lower - fat diet • More than 100 days: healthy mice placed on a lower - fat diet

Humans carry a gene for a protein in cells called apolipoprotein E, which helps clear amyloid - beta from the brain by binding to it and breaking it down.

The REVEAL team recruited subjects who had a parent or sibling suffering from AD and who had signed up to learn about their apolipoprotein E, or APOE, genotype.

He was also missing the Alzheimer's susceptibility allele apo, a well - established variant of a gene for apolipoprotein E carried by approximately two out of three patients.

In 1993, Poirier and his Montreal - based team co-discovered an important genetic risk factor involved in the most common form of the disease: a defective gene, called Apolipoprotein E type 4 (ApoE4), that prevents the normal transport of cholesterol and phospholipids to the brain.

Apolipoprotein E comes in three versions, or variants, called ApoE2, ApoE3 and ApoE4.

Carrying a particular version of the gene for apolipoprotein E (APOE) is the major known genetic risk factor for the sporadic, late - onset form of Alzheimer's disease, but exactly how that variant confers increased risk has been controversial among researchers.

The gene in question, apolipoprotein E (apoE), codes for a protein in the brain's astrocyte cells that seems to help spur nerve cell growth and clear up debris from neuronal injuries brought by head trauma, stroke, or cerebral hemorrhage.

They also tracked Apolipoprotein E (APOE 4), a well - known genetic risk factor for Alzheimer's, as well as lifetime cumulative exposure to unhealthy levels of PM2.5 — particles which are at least 30 times smaller than the diameter of a human hair and frequently cause the haze over urban areas.

Cholesterol - loaded macrophages secrete cholesterol and apolipoprotein E.

In the presence of monensin (an inhibitor of protein secretion), the cells secrete cholesterol, but little apolipoprotein E.

We conclude that apolipoprotein E does not function to remove cholesterol from macrophages but rather to participate in «reverse cholesterol transport.»

After secretion, apolipoprotein E and cholesterol associate with high - density lipoprotein to form a particle that can deliver cholesterol to the liver by receptor - mediated endocytosis.

Apolipoprotein E is a protein that is important in the repair and recovery of brain cells that have been damaged due to concussion.

After finishing the survey, participants in the study can opt for an additional study and consider submitting DNA collected by a cheek swab to be tested for variants at the Apolipoprotein E (APOE) gene.