Sentences with phrase «as aberrant»

Lixenberg's video installation captures life in Imperial Courts in a spectrum from drama and play to aimlessness and routine, enhancing our grasp of the normalcy of life in a part of the American inner - city habitually derided as aberrant and extreme.

The mosquito - borne parasite Dirofilaria immitis is known to infect multiple species, including dogs, cats, ferrets, wolves, coyotes, foxes, sea lions, and even humans.1 Canids, including dogs, are the definitive hosts, while cats are viewed as aberrant or atypical hosts.1 Unlike dogs, in North and South America, D immitis is the only filarial disease that infects cats.2

But such successes will be rare: Waxman is as aberrant in his context as Amanda Hocking is in hers.

But what can you expect, as aberrant growths die and break down, attempting to move through your organs of elimination?

Those anecdotes are often dismissed as aberrant behaviors — opportunistic protein snacks added to a diet made mostly of salad.

zorros is as hopeful, in its own way, as other of Arguedas's books, and that the novelist did not renounce his faith in liberation through transculturation, Other writers make similar assertions about Arguedas, but dismiss Los zorros as aberrant.

Not exact matches

As the architectural historian Walter C. Kidney once commented, «It was not that he was eccentric; indeed, confronted with Cram, the modern world probably seemed aberrant.»

Atheists are fanatical advocates of the aberrant theory of evolution and as such, should be able to understand that.

Secondarily, there are «concentration effects,» a tendency for aberrant behaviors such as crime and illegitimacy to flourish in the ghetto because of its isolation from mainstream society.

Although surveyors of the religious scene have been mentioning the Mormons for almost as long as Mormonism has been in existence, their reports have always placed the Saints outside the mainstream, treating them as a sort of aberrant footnote to the nation's religious life.

I had to read that thing as part of a course in aberrant psychology at grad school.

Needless to say our more mechanistic colleagues regarded these as somewhat aberrant, if not bizarre, activities!

The act of reprogramming cells to make them as capable as ones from embryos apparently can result in aberrant cells that age and die abnormally, suggesting there is a long way to go to prove such cells are really like embryonic stem cells and can find use in therapies.

To acquire new insights into the biology and possible therapy of these tumors, Feigin et al. looked for aberrant expression of G protein — coupled receptors, cell signaling proteins that have been successfully targeted for treatment of other disorders such as depression.

«We identified the cytosolic protein Vms1 as a key component of a novel pathway termed mitoRQC that protects mitochondria from the toxic effects of such aberrant proteins,» explain the authors of the study.

As Weeks digs deeper into the psyche of eccentrics, he gives an insightful analysis of their psycholinguistic traits, often exhibited as degrees of apparently aberrant self - reverential speech and writinAs Weeks digs deeper into the psyche of eccentrics, he gives an insightful analysis of their psycholinguistic traits, often exhibited as degrees of apparently aberrant self - reverential speech and writinas degrees of apparently aberrant self - reverential speech and writing.

Christianson said his team uses neuroscience techniques «to investigate the biological basis for social cognition with the hope that we can better understand and treat people with conditions marked by aberrant social cognition such as autism or schizophrenia.»

Christianson said the findings set the stage for a large - scale investigation of the brain circuits that work together to orchestrate responses to social emotional information with the hope that such research will lead to better treatment for people with conditions marked by aberrant social cognition, such as autism or schizophrenia.

Urban unwilding Of course, as more and more coyotes venture into cities, the number of aberrant troublemakers does grow — even if the majority is well behaved.

Vigilant monitoring of aberrant behavior such as early refill requests, treatment noncompliance, and reports of lost or stolen prescriptions will improve the recognition of signs of abuse.»

The mutated gene, FAA, codes for an aberrant, as - yet - unnamed protein that initiates a cascade of malfunctions in various body systems, including production of blood cells and platelets in the bone marrow.

Just as youthful stem cells use telomerase to offset telomere length loss, cancer cells employ telomerase to maintain their aberrant and destructive growth.

Experimental accelerometers embedded in the collars detect aberrant behaviors such as «streaking» — sudden, panicked flight that might signal an attack.

Star - shaped brain cells known as astrocytes aid perform many indispensible functions, but a new study shows that an aberrant version of the cells may contribute to many neurodegenerative diseases.

As it turns out, the mutant alga also exhibited aberrant organization of cellular membranes when maintained in the dark, but did not exhibit them when maintained in the light.

Blumberg presents examples of aberrant individuals as an underappreciated perspective on developmental and evolutionary processes.

«More importantly, these findings encourage the search for personalized music - based interventions for the treatment of brain disorders associated with aberrant dopaminergic neurotransmission as well as abnormal mood and emotion - related brain activity.»

He adds: «Aberrant mRNAs have been found to be particularly common in patients with neurodegenerative disorders such as amyotrophic lateral sclerosis (ALS).

The current discovery that MAX acts as a tumor suppressor in lung cancer provides evidence that an aberrant SWI / SNF - MYC / MAX network is essential for lung cancer development.

The class of compounds that includes GDC - 0449 could also help contain other cancers, such as ovarian and colorectal cancers, that are not triggered in the same way as medulloblastoma or basal cell carcinoma but that are still partly driven by aberrant Hedgehog signaling.

Transformed cells such as the Jurkat line may show aberrant DNA methylation patterns at specific loci [57], possibly complicating analyses of cytosine methylation and HIV - 1 latency.

On the other hand, aberrant expression of miR - 7 was observed in glioblastomas, and it has been characterized as a putative tumor suppressor by targeting EGFR and AKT (23, 24).

Fragments of fossilized jaw, skull, and tooth, unearthed shortly before World War I from gravel beds, 45 miles south of London, were not, as had been believed, the remains of an aberrant part - human, part - ape «missing link».

Specifically, converging lines of evidence suggest that mechanisms such as oxidative stress and extracellular matrix (ECM) deficit may contribute to the functional impairment of PV neurons, leading to aberrant developmental synaptic pruning of prefrontal cortex neural circuitry and hence a failure in the maintenance of synaptic stability.

The gene encodes a protein called plakophilin 2, which is crucial for the formation and proper functioning of the skin structure, suggesting an aberrant skin barrier as a potential risk factor for atopic dermatitis.

Aberrant expression of TUBB3 has also been found in various tumors of non-neural origin and can be used as a biomarker for cancer aggressiveness and a marker for the tendency to respond poorly to chemotherapy.

Sina Koch (Ehninger, TUD)-- «Aberrant subcellular localization as a potential mechanism contributing to the abnormal signaling of the mutant Flt3 - ITd receptor tyrosine kinase in acute myeloid leukemia» (2007)

What we do know now, as he explains to NPR, is that sexual identity is not an aberrant condition, but part of our genetic history.

Career Goals: Peipei is passionately building up her career as professional research investigator to continue unraveling the mystery of aberrant myelopoiesis with the goal of developing new generation of therapeutic method for cancer & cardiovascular disease.

Prom1 was reported recently to mark cancer stem cells of human intestinal tumours that arise frequently as a consequence of aberrant wingless (Wnt) signalling.

This is in accordance with previous reports that decitabine and 5 - azacytidine produce a marked synergistic effect in combination with suberoylanilide hydroxamic acid and romidepsin in T - lymphoma cell lines by modulating cell cycle arrest and apoptosis.26, 27 As a mechanism of action, KMT2D mutations of B - lymphoma cells promote malignant outgrowth by perturbing methylation of H3K4 that affect the JAK - STAT, Toll - like receptor, or B - cell receptor pathway.28, 29 Here our study indicated that dual treatment with chidamide and decitabine enhanced the interaction of KMT2D with the transcription factor PU.1, thereby inactivating the H3K4me - associated signaling pathway MAPK, which is constitutively activated in T - cell lymphoma.13, 30,31 The transcription factor PU.1 is involved in the development of all hematopoietic lineages32 and regulates lymphoid cell growth and transformation.33 Aberrant PU.1 expression promotes acute myeloid leukemia and is related to the pathogenesis of multiple myeloma via the MAPK pathway.34, 35 On the other hand, PU.1 is also shown to interact with chromatin remodeler and DNA methyltransferease to control hematopoiesis and suppress leukemia.36 Our data thus suggested that the combined action of chidamide and decitabine may interfere with the differentiation and / or viability of PTCL - NOS through a PU.1 - dependent gene expression program.

As highlighted in several articles appearing in this special topic, one of the most well - documented observations in the autism literature is that the brains of individuals with the disorder exhibit aberrant functional connectivity or inter-regional communication (Belmonte et al., 2004).

Recent work in fragile X syndrome suggests aberrant fronto - striatal and fronto - parietal networks and relates these abnormalities «forward» to behavior and «backward» to decreased protein expression.As the field of neuroimaging has matured, it has revealed its promise as a safe, reliable, in - vivo tool in the study of developmental disorders.

As the field moves closer toward understanding the ways in which task - based and resting - state measures can meaningfully capture brain dynamics, it will continue to inform functional connectivity theories of autism and allow investigators to more confidently predict the conditions under which aberrant brain connectivity in ASD will manifest.

Aberrant regulation of the epigenetic information results in changes in cell fate decisions, thereby affecting development and tissue homeostasis, and ultimately leading to disease, such as cancer.

Mice lacking this protein developed an autoimmune disease as a result of aberrant T cell activity and over-inflammation.

This study shows for the first time proteins interacting with Nbeal2 and points to the dysregulation of the canonical signaling pathway of Dock7 as a possible cause of the aberrant formation of platelets in GPS cases and Nbeal2 deficient mice.

Aberrant splicing was associated with the usage of cryptic 3» splice and branchpoint sites, as described for human SF3B1 mutants.

The generation of double - strand DNA breaks as a result of aberrant AID activity is strongly implicated in the genesis of MYC / IG translocations (Robbiani et al., 2008; Dorsett et al., 2007).

My laboratory aims to identify, characterize and validate lncRNA - driven pathways active in allergy - driving helper T cells and airway epithelial cells that could hold promise as therapeutic targets in altering the aberrant immune responses underlying asthma.