Sentences with phrase «as cancer tumours»

Not exact matches

Darzalex, however, has not yet reached its peak potential as the drug moves into earlier stages of the disease and is being tested on solid tumours like lung cancer.

Instead of giving a cancer patient a cocktail of 15 drugs as is done now, doctors could print 15 tumours from a biopsy and determine which one is most effective before issuing a prescription to the patient.

A doctor exams mammograms, a special type of X-ray of the breasts, which is used to detect tumours as part of a regular cancer prevention medical check - up at a clinic in Nice, south eastern France January 4, 2008.

«This phase III trial will be noteworthy for being the first prostate cancer trial to assess a biomarker, namely AR - V7 in circulating tumour cells, as a predictor of response at the same time as testing the efficacy of the drug,» Prof Taplin will conclude.

PTEN is known as a tumour suppressor gene meaning that it typically slows the growth of cells and its loss can lead to cancer.

The study has been tested in metastatic patients with different primary tumours such as breast, colon and lung cancer.

This time, she was given different chemotherapy — docetaxel and gemcitabine — as it was assumed that her cancer had grown resistant to the previous drugs, and, after several weeks, the tumours had shrunk right down.

But as inflammation is known to promote the growth of cancer, they assumed that the cells were helping the tumours to grow.

The main reason why people die of cancer is that the cancer cells spread to form daughter tumours, or metastases, in vital organs, such as the lungs and liver.

«Our results suggest that we've been looking at these cancer drugs the wrong way — as tumour - targeting drugs — instead of what we now feel is their most important biological role: as immune stimulating therapy.»

Breast cancer patients who have radiotherapy targeted at the original tumour site experience fewer side effects five years after treatment than those who have whole breast radiotherapy, and their cancer is just as unlikely to return, according to trial results published in The Lancet.

The importance of exosomes in the tumour microenvironment has been demonstrated within the field in recent years, as it has been shown that tumour development is halted if the production of exosomes inside the cancer cell is stopped.

To date, scientists have had limited understanding of how cancers change genetically, or evolve, as they spread from the primary tumour.

But around 3 per cent of males developed a brain cancer known as malignant glioma, and up to 6 per cent grew heart tumours called schwannomas (BioRxiv, doi.org/bjfm).

This means that the cancer cells are no longer able to communicate as effectively and the tumour does not grow as it otherwise would.

According to Rottenberg, this new immunotherapy has been only modestly successful when used on other frequent tumours such as breast cancer - also, it results in side - effects and enormous costs.

The commission concludes that the tumours likely to result from the tests — such as thyroid or brain cancer — either can not be identified by screening or can not be treated.

In research funded by Sparks charity, Great Ormond Street Hospital Children's Charity and Cancer Research UK, researchers at the University of Cambridge have developed a test for blood and cerebrospinal fluid samples that looks for a specific panel of four pieces of short genetic code known as microRNAs, which are found in greater quantities in malignant germ cell tumours.

Around 70 % of all cases of breast cancer are oestrogen - receptor positive, meaning that the cancer cells have a particular protein (known as a receptor) that responds to the female sex hormone oestrogen, enabling the tumour to grow.

In addition, they showed for the first time that these genes are often the same as those that are altered in breast tumours - when a tumour develops, the DNA within the cancer cells themselves mutates.

This ductoscopy technique enabled the pathologists to identify the exact duct leading to the tumour and subsequently classify genetic alterations either increasing or decreasing as they moved nearer to the cancer.

This included glioblastoma, the most aggressive of brain tumours, as well as lung, prostate, ovarian, breast, pancreatic and skin cancer.

Prostate cancer patients whose tumour cells have high levels of this molecule are more than twice as likely to see their disease return following surgery.

«There is currently no national screening programme for ovarian cancer, as research to date has been unable to provide enough evidence that any one method would improve early detection of tumours.

The team also found that there were also cases of other cancer types in families with these hereditary mutations such as leukemias and brain tumours.

Dr Harcharan Rooprai, King's College Hospital, comments: «The promising results seen are encouraging and suggest that these polyphenols have great therapeutic potential not only for brain tumours but pancreatic cancer as well.»

This unfortunate and rare side effect of the biopsy provided Nicola Valeri at the Institute of Cancer Research in London and his colleagues with a kind of stopwatch — an exact point in time when a few cells left as the needle was withdrawn began their two year evolution into a tumour.

It could have implications for HIV patients, both with and without cancer, as it can work on HIV reservoirs and tumour cells independently.

My future career plans ideally would be to continue as a postdoc in tumour immunology and also to continue working on the Cancer Compass.

First, the researchers inhibited the tumour cell mitochondria, by restricting the cancer cells only to glucose as a fuel source; then, they took away their glucose, effectively starving the cancer cells to death.

The panel also called for «aggressive research» on using RU486 and other drugs in the antiprogrestin class as contraceptives and as treat - ment for endometriosis, uter - ine fibroids, advanced breast cancer and meningioma brain tumours.

As an example, Martin von Lohuizen of the Netherlands Cancer Institute, says Berns's own laboratory has developed a mouse with a gene called PIM1 which rarely causes tumours but sensitises the mouse to the action of a second carcinogen.

«The results are really interesting for biomedicine,» explains the researcher, «as the Hedgehog pathway is overexpressed in some of the most invasive tumours, such as the most common kind of skin cancer.»

The study, published in Nature Communications, examined the changes that occur in cancer cells as they break away from tumours in cell cultures, zebrafish and mice.

Although it might be useful to reduce that collateral damage for some applications, he says it could prove beneficial in others — in a cancer treatment, for example, wiping out «bystander» RNA as well as target RNA might offer a more effective way to fight a tumour.

This accuracy really shows up in areas such as radiation treatment for cancer, where the dose delivered to the patient's tumour needs to be accurate to within 3 per cent to achieve the best outcome.

«If successful, I envisage it can be a good alternative treatment in the future, one which is low cost and yet effective for the treatment of cancers involving solid tumours, as it might minimise the side effects of drugs.»

In the mice, the neuron - like cells did not grow as quickly as the original cancer cells, and analyses of the tumour tissue from patients show that those with a high level of the estrogen receptor have a better survival rate that those with a low.

Cancers (like brain tumours) that present as medical or surgical emergencies are more likely to be addressed earlier.

Rather than a tumour suppressor, we show here that RASAL2 actually acts as a cancer promoting molecule in TNBC.

TNBC is deadly because, unlike other types of breast cancers such as estrogen receptor (ER) positive or HER2 amplified breast tumours which have effective targeted therapy, TNBC tumours do not respond to targeted therapy.

Scientists tested for microRNA 135b in 485 patients with bowel cancer and found that levels were at least four times as high in tumours as in healthy tissue, and that patients with the highest levels survived the least long.

Between 32 % to 75 % of patients diagnosed with head and neck cancers cancer have surgery to remove the tumour as part of their primary cancer treatment.

«This important study not only adds more genetic risk factors to the list of those known for testicular germ cell tumours — the most common cancer in young men — but also adds detail to the emerging picture of testicular cancer as a strongly heritable disease.

DNA shed from tumour cells has been identified as a non-invasive method of screening biomarkers for the early diagnosis and prognosis of cancer

Many tumours lack the specific characteristics needed in order for the immunotherapy to recognise and attack the cancer cells as enemies.

Recently, DNA shed from tumour cells has been identified as a non-invasive method of screening biomarkers for the early diagnosis and prognosis of cancer.

Research into the genes that control how breast cancer responds to treatment will help doctors provide patients with the most effective treatment for their tumour as early as possible, increasing their chance of survival.

We have developed pre-clinical models to identify genes, both in the tumour cells and in the microenvironment that regulate the spread of cancer to specific organs such as the liver, lungs and brain.

As seen with pseudo-coloured scanning electron microscopy, two cell - killing T - cells (red) attack a squamous mouth cancer cell (white) after a patient received a vaccine containing antigens identified on the tumour.