Sentences with phrase «as endocytic»

Not exact matches

However, endocytic waves may be initiated by clathrin through a positive feedback mechanism between clathrin and downstream proteins which includes actin regulating proteins as well as membrane proteins such as PIP3.

Furthermore, the membrane microdomains induced by BAR domains are expected to function as diffusion barriers, which may for example trap membrane - associated receptor and cargo molecules at the endocytic bud.

Thus, the endocytic machinery appears to act as a «sensor gauge» capable of triggering diverse biological processes depending on the intensity of the stimulus received by the cell.

Endocytosis has traditionally been viewed as a mechanism for achieving signal attenuation: activated cell surface receptors are internalised and trafficked through endocytic vesicles to lysosomes, where they are degraded.

We are using the epidermal growth factor receptor (EGFR) as a model «endocytic system» to address these issues.

Cell surface receptors can be endocytosed by both clathrin - dependent and clathrin - independent mechanisms, but, as yet, there is no clear understanding of why alternative endocytic routes exist or how receptors are committed to a particular route.