Sentences with phrase «as organisms age»

As organisms age, the function of neurons becomes compromised and this often results in the death of neurons (or neurodegeneration).

Perhaps, as organisms age, they lose their ability to silence genes effectively, suggests Leonard P. Guarente of the Massachusetts Institute of Technology.

And according to a third theory, as organisms age they deteriorate and must spend more energy to repair cell damage — to the detriment of other essential physical functions.

Generally, as an organism ages, not only are there more damaged proteins in need of disposal, but the proteasome itself becomes damaged and less efficient in clearing out the damaged proteins.

«The orchestration of gene expression no longer seemed coordinated as the organism aged and the results were confusing because genes related to the same function were going up and down at the same time,» says Petrascheck.

Because the PP4 DNA of worms is over 90 % identical with that of humans, it is possible that the protein plays a similar role in all animals as a universal regulator of meiosis, particularly as an organism ages.

It is clear that neuropeptide levels in the brain change in defined ways as an organism ages but the role of neuropeptide signaling in aging has not been explored in a systematic way, in part due to a lack of tools to study these molecules.

Not exact matches

The age - long and still influential Christian doctrine of bodily resurrection thus goes back to primitive Hebrew behaviorism, which always conceived soul as a function of the material organism and never, like Greek philosophy, conceived immortality as escape from the imprisoning flesh.

The fossil record includes the Stromatolites, colonies of prokaryotic bacteria, that range in age going back to about 3 billion years, the Ediacara fossils from South Australia, widely regarded as among the earliest multi-celled organisms, the Cambrian species of the Burgess shale in Canada (circa — 450 million years ago) the giant scorpions of the Silurian Period, the giant, wingless insects of the Devonian period, the insects, amphibians, reptiles, fishes, clams, crustaceans of the Carboniferous Period, the many precursors to the dinosaurs, the 700 odd known species of dinosaurs themselves, the subsequent dominant mammals, including the saber tooth tiger, the mammoths and hairy rhinoceros of North America and Asia, the fossils of early man in Africa and the Neanderthals of Europe.

Many factors, such as antioxidant mechanisms and dietary and biological factors, influence metabolism, Redman says, but current theories hold that a slower metabolism is most beneficial for healthy aging and that organisms that burn energy most efficiently should experience the greatest longevity.

This method would also enable them to follow potential aging processes that occur in blood stem cells in detail as they occur naturally in a living organism.

PAHs could stunt growth, an effect that could ripple through the ecosystem: smaller organisms are picked off by predators at a young age, leaving less food for larger fish such as red snapper and bluefin tuna.

Organisms like zebra fish readily dedifferentiate cells near the injury, undergoing a cellular age regression in which «they form something like stem cells, although they are not quite the same as stem cells,» says Keating.

«Like many labs, we use C. elegans — a tiny roundworm — as a model organism to reveal important lessons about aging and autophagy,» explains Hansen.

Finch's ideas about senescence from his grad school days have also held up: The popularity of the Hayflick model has declined as other research questioned its relevance to aging in whole organisms, and recent studies in long - lived nematodes have confirmed Finch's hunch that brain hormones control aging (see Johnson Review).

In all species where it has been shown to delay aging and the diseases of aging, it affects the regulation of energy and the ability of cells and the organism to respond to changes in the environment as they age.»

The transcription factor Gcn4 is conserved in over 50 different organisms, including mammals, and it likely play a significant role in the aging of these organisms as well.

A group of scientists have used a tiny roundworm called C. elegans to discover the mechanisms involved when multicellular organisms die, particularly as a result of old age.

Dr. Hansen's group focused on investigating the molecular mechanisms by which the nutrient sensor TOR modulates aging, using the nematode C. elegans as her primary model organism.

This year the organizers overtly recognized the history of our biomedical research niche in which C. elegans nematodes are used as a model organism (see our SAGE blog on how C. elegans models are used to study aging).

The researchers then concluded that as the amount of NAD + in cells declines with age, there aren't enough of these molecules to prevent harmful interactions between proteins called DBC1 (which is found across a wide range of organisms, from bacteria to humans) and PARP1 (a protein that is known to control DNA repair).

We will use the fruitfly Drosophila melanogaster as an experimental model, as this tractable organism experiences age - related changes of their stem cells that are similar to the ones observed in mammals.

Preliminary data indicates that an organism loses the ability to maintain the proper balance of metals as it ages and that this loss contributes to age - associated mortality.

«By learning how organisms such as the zebrafish can regenerate damaged tissues and applying these lessons to humans, scientists at MDIBL are increasing our understanding of how we might one day slow and potentially reverse the degenerative effects of aging.

The researchers first discovered ascarosides as a signaling molecule in C. elegans, a nematode used as a model organism to study cell, developmental and nervous system biology, as well as human aging and diabetes.

As one of the three initial cores established when the Buck Institute was founded, the Genomics Core has played a vital role in helping shape investigations in the basic molecular biology of aging, from assisting in the investigation of how specific drugs can extend lifespan in simple model organisms such as the nematode C. elegans, to facilitating studies in various animal models of age - related diseasAs one of the three initial cores established when the Buck Institute was founded, the Genomics Core has played a vital role in helping shape investigations in the basic molecular biology of aging, from assisting in the investigation of how specific drugs can extend lifespan in simple model organisms such as the nematode C. elegans, to facilitating studies in various animal models of age - related diseasas the nematode C. elegans, to facilitating studies in various animal models of age - related disease.

Aging itself is a system - wide movement towards chemical equilibrium (away from the highly regulated far - from - equilibrium state) and as such is an imbalance from which all living organisms suffer.

C.C. Little, the inventor of the modern lab mouse and founder of the Jackson Laboratory, had long used «the age old enmity of woman and the Muridae» as a sales pitch for his model organism.

Additionally, aging of the organism as a whole is modulated by hormonal signals produced by neurons and other tissues.

It has been found that as we age the number of healthy organisms in the large intestine starts to decline, upsetting this delicate balance, which influences both immune function and digestive health.

This idea, however, is far from true as there are many reliable scientific documents indicating that the well balanced and unrefined entirely plant - based vegan diet provides human organism with all essential nutrients and is appropriate for all age groups including children.

Numerous subsequent studies have confirmed that a calorie restriction of 30 to 60 percent of ad libitum intake increases the life span by similar amounts in a range of organisms including yeast, roundworms and rodents, while simultaneously decreasing or delaying the occurrence of age related diseases such as numerous cancers (including lymphomas, breast and prostate cancers), hypertension, stroke, diabetes, nephropathy, autoimmune disorders and other risks factors for cardiovascular disease (3,4).

«Minions,» the hilarious new animated prequel to the «Despicable Me» franchise, goes back to the beginning when the Minions started out as single - celled yellow organisms, then evolved through the ages, perpetually servi...

Starting as single - celled yellow organisms, Minions evolve through the ages, perpetually serving the most despicable of masters.

High levels of IGF - 1 has been shown in a wide variety of organisms, including humans, to be associated with increased risk of death from age - related diseases such as cancer and heart disease.

Humans have modified organisms for ages, making the dog species as variegated as Chihuahuas and mastiffs, transforming corn from a slender grass into a stalk studded with cobs of nutritious grain.

Those islands are there because as the volcanic corals have subsided, the sea level has gone up (since the last ice age), and the growth of coral organisms has kept up.