Sentences with phrase «association of alleles»

Martins RN, Association of alleles carried at TNFA - 850 and BAT1 - 22 with Alzheimer's disease.

The association of an allele with disease is a measure of statistical, not clinical significance.

Not exact matches

Genome - wide association studies (GWAS) have demonstrated a significant polygenic contribution to bipolar disorder (BD) where disease risk is determined by the summation of many alleles of small

Estimation of allele frequency and association mapping using next - generation sequencing data.

Estimation of allele frequency and association mapping using next - generation sequencing data Kim, S. Y., K. E. Lohmueller, A. Albrechtsen, Y. Li et al. 2011.

Seventy mtDNA SNPs met our minimum minor allele frequency threshold of 5 %, and were included in association tests with demographic and symptomatic variables associated with ME / CFS.

However, prevailing GWA data analysis methods are focusing on the association of individual SNP alleles with a complex disease, although multiple alleles are involved by definition.

Some of the associated variants were super rare (MAF < 1 %), suggesting that genotyping studies like this are well - powered to detect associations even at allele frequencies below one percent.

We found a significant association between rs10524523 and risk of LOAD in APOE 33 homozygotes but in the opposite direction as the previously reported association (the very long allele was underrepresented in cases vs controls in this study (P =.004]-RRB-.

Common risk alleles with a known association with a condition can inform an individual of an increased or decreased risk of developing the condition in question; however, the degree of certainty is often unknown.

However, in subgroup analyses stratified by age, we found that the deletion allele was associated with increased risk for lung cancer among individuals < 50 years of age (OR 2.17, CI 1.19 - 3.97), and that the association was gradually reduced with increasing age (p = 0.01).

Per Allele Association of a Sexually Dimorphic Instrument Testing if Waist - to - Hip Ratio Adjusted for Body Mass Index Associates With Type 2 Diabetes and / or Coronary Heart Disease

It has been suggested that the positive associations reported in case - control studies may have resulted from recall bias or confounding by factors such as smoking.19, 34 However, because we observed an association between coffee and risk of MI among carriers of the * 1F allele, and not among those homozygous for the * 1A allele, the associations between coffee and MI are unlikely due to recall bias or residual confounding.

For example, in collaboration with Dr. Leigh Anne Clark's group at the Clemson University in South Carolina we have identified an association of a specific DLA class I allele with pancreatic acinar atrophy in the German Shepherd Dog.

While genome - wide association studies (GWAS) are an efficient approach for the identification of recessive alleles, they require several unrelated affected individuals [17]--[19].

Although the maltreated and comparison groups were comparable in terms of racial composition, to prevent spurious associations that can result from variation in allele frequency and prevalence of trait by population (24), ancestry proportion scores were generated and included as a covariate in all analyses.

Importantly, we also reveal a novel and surprising negative association between individualism — collectivism, frequency of S allele carriers of the serotonin transporter gene and global prevalence of anxiety and mood disorder.

Allele association studies have linked the 48 bp repeat polymorphism of the DRD4 gene with normal variations of neonatal, infant, and adult temperament [85], but also with clinical hyperactivity (ADHD)[93, 94].

The widely used strategy of allele association investigates correlations of gene variants with phenotypes, i.e., it probes if individuals with a trait of interest carry a specific gene variant more frequently than individuals in a control group (case - control studies).

While Dutch researchers have failed to replicate this association [97, 98], parental genetic data and family - based analyses in the Hungarian sample showed a highly significant non-transmission of the 7 - repeat allele (and the -521 T ~ 7 - repeat haplotype) to securely attached infants, as well as a trend for preferential transmission to disorganised infants [95].

Association of the paternally transmitted copy of common valine allele of the Val66Met polymorphism of the brain - derived neurotrophic factor (BDNF) gene with susceptibility to ADHD

Association of the 480bp DAT1 allele with methylphenidate response in a sample of irish children with ADHD

A meta - analysis of association studies between the 10 - repeat allele of a VNTR polymorphism in the 3 ′ UTR of dopamine transporter gene and attention deficit hyperactivity disorder

Meta - analysis of the association between the 7 - repeat allele of the dopamine D (4) receptor gene and attention deficit hyperactivity disorder

The present study examined associations of delinquency with: (1) the high and low activity alleles of MAOA - uVNTR, BDNF Val66Met, and 5 - HTTLPR genotypes; (2) two -, three -, and four - way interactions of each genotype with family conflict and sexual abuse; and (3) two -, three -, and four - way interactions of each of these genotypes with the child - parent relationship, adjusting for family conflict and sexual abuse.

Other studies identify associations between an interaction of the long, high - activity allele (MAOA - uVNTR - L) and childhood adversity and antisocial behavior among females (Sjoberg et al., 2007; Aslund et al., 2011), and aggressive behavior (Manuck et al., 2000; Beitchman et al., 2004) and violent crime (Tikkanen et al., 2009) among males.

This direction of the association, however, is concordant with the idea that the minor allele of SNP rs11568817 engenders a risk for higher levels of CU traits, which in turn were found to be associated with lower levels of peripheral serotonin.

Some studies (Retz et al., 2004; Gerra et al., 2005), but not all (Sakai et al., 2007), have reported an association between the short (S) less - active allele of the serotonin transporter, 5 - HTTLPR, and aggression, impulsiveness, and conduct disorder.

Moreover, most of these studies examined the same DRD4 variation studied here, with the 7 - repeat allele predicting fewer externalizing problems and more prosocial behavior in conjunction with supportive parental attributes or interventions and, conversely, with more externalizing problems and early attachment difficulties in association with negative parenting environments.