Sentences with phrase «asymmetric cell division in»

Title: The par complex and integrins direct asymmetric cell division in adult intestinal stem cells Authors: Goulas S, Conder R, Knoblich JA Date: 2012 Publication Details: Cell Stem Cell 2012, 11 (4): 529 - 540

Directional Notch trafficking in Sara endosomes during asymmetric cell division in the spinal cord.

«Live cell imaging of asymmetric cell division in fertilized plant cells: Insight into why leaves grow up and roots grow down in flowering plants.»

An asymmetric cell division in non-stem cells can instead result in two daughter cells with very different fates, such as one large cell that reinitiates cell division prematurely and a much smaller cell that either grows very slowly or dies.

Brummendorf TH, Dragowska W, and Lansdorp PM, Asymmetric cell divisions in hematopoietic stem cells.

Not exact matches

But in a process called asymmetric division, a cell divides into two daughters that are not identical — a skin stem cell divides into another skin stem cell and a regular skin cell, for example.

«Neural stem cell divisions appear to be much more asymmetric than we had previously anticipated,» states Darcie Moore, postdoc in the group of Sebastian Jessberger and lead author of the study.

Not only did the group succeed in visualizing the real time events of zygote polarization and asymmetric cell division, they were able to quantify the dynamic patterns of the cytoskeleton (i.e. formation of the ring structure and longitudinal array of MTs and F - actin, respectively).

This results in an unequal (asymmetric) cell division, generating a relatively small cell on top and a large cell at the bottom.

The group succeeded in visualizing for the first time, how the cytoskeleton of plant egg cells is disassembled after fertilization and then reorganized to create a polarity in the cell that eventually leads to asymmetric cell division.

«Although polarization and asymmetric cell division of zygotes to form the body axis is a common phenomena found in algae, mosses, and flowering plants, the origin of cell polarity and how asymmetric cell division occurs have remained a mystery up to now,» says Dr. Minako Ueda, a lecturer at ITbM, Nagoya University and a leader of this research.

«We were able to show by live cell imaging that polarization of the cell occurs after fertilization of the egg cell, and both MTs and F - actin play a role in inducing asymmetric cell division to form the plant's body axis,» says Ueda.

In order to investigate their specific roles, they used inhibitors of each protein to see their effect on zygote polarization and asymmetric cell division.

The group's results show that MTs are responsible for elongation of the zygote along the top - bottom axis, whereas F - actin plays a role in moving the nucleus towards the top part of the zygote, to make it ready for asymmetric cell division.

In parallel, the roles of symmetric and asymmetric cell divisions are investigated as a mechanism for governing stem cell self - renewal and differentiation during embryonic development and in the adulIn parallel, the roles of symmetric and asymmetric cell divisions are investigated as a mechanism for governing stem cell self - renewal and differentiation during embryonic development and in the adulin the adult.

Jürgen Knoblich Institute of Molecular Biotechnology Asymmetric cell division and proliferation control in Drosophila [email protected] [phone]

Abstract We discovered that a subset of satellite cells in skeletal muscle are self - renewing stem cells that give rise to myogenic progenitors through asymmetric apical - basal cell divisions.

Importantly, this results in an abnormal increase in centrosome number, a 10-fold reduction in the numbers of satellite stem cells undergoing asymmetric divisions, and a marked decrease in the generation of myogenin - expressing progenitors.

She also investigates how asymmetric cell division impacts on the cellular potential to give rise to multiple lineages in vivo.

Accordingly, our data suggests that the failure of regenerative myogenesis to keep pace with disease progression in DMD is not due to muscle stem cell exhaustion, but rather is due to a cell - autonomous deficiency in asymmetric division.

Vascular Cell Biology New Roles for BMP Signaling in Angiogenesis Victoria Bautch, University of North Carolina, Chapel Hill Coordination of angiogenesis by asymmetric cell division Shane Herbert, University of MancheCell Biology New Roles for BMP Signaling in Angiogenesis Victoria Bautch, University of North Carolina, Chapel Hill Coordination of angiogenesis by asymmetric cell division Shane Herbert, University of Manchecell division Shane Herbert, University of Manchester

Centrosome asymmetry has been implicated in asymmetric cell divisions.

The first talk of the meeting was by Juergen Knoblich, and it was great to hear about his current projects, using Drosophila genetics to understand cell cycle exit and quiescence plus the contribution of changing the balance of asymmetric versus symmetric divisions in development of various disorders.

Furthermore, cells in which MELK had been depleted displayed asymmetric division (Figure 6G), characterized by an unequal allocation of cell mass into daughter cells.