Sentences with phrase «at apolipoprotein»

At apolipoprotein A-V (APOA5), carriers of rare non-synonymous mutations were at 2.2-fold increased risk for MI.

After finishing the survey, participants in the study can opt for an additional study and consider submitting DNA collected by a cheek swab to be tested for variants at the Apolipoprotein E (APOE) gene.

Not exact matches

HDL with a small proinflammatory protein called apolipoprotein C - III (apoC - III) on its surface may nearly double the risk of heart disease in healthy men and women, according to Frank Sacks, professor of cardiovascular disease prevention at the Harvard School of Public Health and senior author on a paper in the April Journal of the American Heart Association.

They also tracked Apolipoprotein E (APOE 4), a well - known genetic risk factor for Alzheimer's, as well as lifetime cumulative exposure to unhealthy levels of PM2.5 — particles which are at least 30 times smaller than the diameter of a human hair and frequently cause the haze over urban areas.

For decades, scientists have known that people with two copies of a gene called apolipoprotein E4 (ApoE4) are much more likely to have Alzheimer's disease at age 65 than the rest of the population.

Together, they looked at two well - known genetic risk factors for CKD in black people, the mutated G1 or G2 variations in the gene known as apolipoprotein L1 (APOL1).

Carriers of the apolipoprotein (ApoE) ɛ4 allele are at greater risk for developing late - onset Alzheimer's disease (AD), develop AD at an earlier age, and experience a more severe cognitive decline and shorter survival times.

Scientists at the Gladstone Institute of Neurological Disease (GIND) have discovered that two main causes of AD amyloid - beta (Aβ) peptides and apolipoprotein E4 (apoE4) impair the growth of new neurons born in adult brains.

Understanding the Role of Apolipoprotein E in Microglia Edoardo Marcora, PhD Icahn School of Medicine at Mount Sinai (New York, NY)

Led by Michael Holzer at the Institute of Experimental and Clinical Pharmacology, the research team went on to determine that «prolonged freezing at -20 °C or -70 °C led to a shedding of apolipoprotein - AI from HDL and to the formation of large protein - poor particles, indicating that HDL is irreversibly disrupted.»

Recent evidence has connected MI risk with coding - sequence mutations at two genes functionally related to APOA5, namely lipoprotein lipase and apolipoprotein C - III (refs 18, 19).

Mipomersen (Kynamro) reduces low - density lipoprotein (LDL) cholesterol by silencing a gene that produces apolipoprotein B - 100, a building block of LDL; the drug can treat familial hypercholesterolemia, an inherited disease that may cause heart attacks at an early age.

Specifically, the researchers looked at mutations in the apolipoprotein A5 gene, a known determinant of triglyceride concentrations.