Sentences with phrase «autism risk mutations»

Autism risk mutations inactivate this gene and, in the absence of their own ability to produce carnitine and without adequate outside supplementation, neural stem cells become less efficient at self - renewal.

Not exact matches

Previous studies have shown that inherited mutations in a gene (called TMLHE) that is required for carnitine biosynthesis are strongly associated with risk for development of autism - spectrum disorders, but the basis for that association has been unclear — until now.

Page and his colleagues, who use animal models to understand how autism risk factors impact the developing brain and to identify potential treatments for the condition, have found that animals with mutations in the autism risk gene phosphatase and tensin homolog (Pten) mimic aspects of autism, including increased brain size, social deficits and increased repetitive behavior.

Based on the authors» previous discoveries, it is known that de novo mutations contribute to risk, particularly in sporadic cases where there is no family history of autism.

This specific spontaneous mutation, which we found in a sufficient number of cases, announced itself as an autism risk factor.»

New research suggests evolution is favoring the disorder: A study in PLOS Genetics says certain genetic mutations that are associated with an increased risk of autism were passed on during evolution because they are also associated with improved cognitive abilities.

This approach has identified genes that are relevant to for example autism, as well as individual mutations that substantially increase or decrease the risk for e.g. cardiovascular disease.

Factors associated with a higher risk of autism include having parents older than 30, maternal illness during pregnancy, genetic mutations, birth before 37 weeks» gestation and a multiple birth.