Sentences with phrase «b cell proliferation»

Results : The application of specific optimised conditions induce multiple rounds of memory B cell proliferation equally across Ig isotypes, differentiation of memory B cells to antibody secreting cells, and importantly do not alter the Ig genotype of the stimulated cells.

Follicular dendritic cells produce IL - 15 that enhances germinal center B cell proliferation in membrane - bound form.

The major mechanism of B cell suppression by MSCs is attributed partly to the physical contact between MSCs and B cells and in part to the soluble factors released by MSCs; this leads to the blocking of B cell proliferation in the G0 / G1 phase of the cell cycle with no apoptosis 28, 29, 30.

When GARP was depleted from these cells, there was increase in B cell proliferation and activation.

«Foxo1 is a tumor suppressor gene, but it promotes B cell proliferation in the germinal center,» he said.

Not exact matches

B - 1a cells in meningeal space secrete natural antibodies, which promote the proliferation of oligodendrocyte precorsors.

Overall, the presence of B lymphocytes was associated with increased tissue proliferation, reduced cell death and a more supportive environment for wound healing.

«Our findings provide direct evidence that B cells reside in the mouse neonatal brain and promote both oligodendrocyte proliferation and neuron myelination.

They promote the proliferation of B cells that produce highly selective antibodies against invading pathogens while weeding out those that generate potentially harmful ones.

Reviving the BATF levels recovered the proliferation of Foxo1 - deficient B cells in the germinal center.

They found substantial differences following influenza vaccination in the production of immune - modulators that determine the type of T - cell response and in the proliferation and production of antibodies by B cells.

For the proliferation and differentiation to occur, B cells must cycle between the two zones.

Using mice deficient in Del - 1, they found that the protein promotes proliferation and differentiation of hematopoetic stem cells, sending more of these progenitor cells down a path toward becoming myeloid cells, such as macrophages and neutrophils, rather than lymphocytes, such as T cells and B cells.

Overexpression of GARP reduced the proliferation and activation of B cells.

The dark zone is where B cells undergo proliferation.

«Role of RNA binding protein in driving cancer, leukemia study reveals: Abnormally expressed in cancer cells, the protein was found to promote the proliferation of B cells in B - cell acute lymphoblastic leukemia.»

In the case of IGF2BP3 and B - cell leukemia, the overall effect of the RNA binding protein is to promote the proliferation of B cells by shifting the expression of a large number of genes, Sanford said.

With this technique, CpG oligonucleotides are only internalized into B cells that recognize the specific antigen, and these cells are therefore the only ones in which TLR9 is activated to induce their proliferation and development into antibody - secreting plasma cells.

Analogous to bacterial infection, CpG - B triggers the differentiation of both plasmacytoid and conventional DCs, as well as the proliferation and activation of B cells.

More specifically, we found that T cells from DGKζ − / − and Cbl - b − / − mice exhibit similar levels of enhanced proliferation at low levels of TCR stimulation.

Hsiou - Chi Liou and colleagues find that c - Rel, a lymphoid - specific member of the NF - kappaB / Rel family of transcriptional factors, is essential for B lymphocyte survival and cell cycle progression, [i] and that it is important for inducible cytokine and cytokine receptor expression and a key regulator of early activation and proliferation in T cells.

The addition of IL - 2, as expected, enhanced the proliferation of WT T cells, but not completely to levels observed with DGKζ − / − CD8 + T cells + IL - 2 or to Cbl - b − / − and DKO CD8 + T cells (Fig. 3D).

In contrast, proliferation differences seen between DGKζ − / − or Cbl - b − / − CD8 + T cells mostly dissipate upon administration of exogenous IL - 2, which indicates that the enhanced production of IL - 2 in stimulated Cbl - b − / − CD8 + T cells is the primary factor responsible for the observed differences between the two genotypes.

MSCs inhibit the proliferation of B cells activated with anti-immunoglobulin (Ig) antibodies, anti-CD40L antibody and cytokines (IL - 2 and IL - 4) 31.

Deletion of DGKζ or Cbl - b comparably enhanced CD8 + T cell functional responses, such as proliferation, production of IFN - γ, and generation of granzyme B when compared with wild type T cellsb comparably enhanced CD8 + T cell functional responses, such as proliferation, production of IFN - γ, and generation of granzyme B when compared with wild type T cellsB when compared with wild type T cells.

It is involved in the regulation of B - cell activation and proliferation.

DEC1 / STRA13 is a key negative regulator of activation - induced proliferation of human B cells highly expressed in anergic cells

Its binding to DPP4 induces T - cell proliferation and NF - kappa - B activation in a T - cell receptor / CD3 - dependent manner.

Inhibition of cell proliferation (B) of MCF7, MCF7 / HER2, or BT474 cells treated for 6 days with F3 - IgG, trastuzumab, or isotype control antibody.

Wnt / b - catenin / Tcf1 pathway controls mouse embryonic stem cell cycle progression and proliferation by regulating the Ink4 / Arf locus.

Abnormally expressed in cancer cells, the protein was found to promote the proliferation of B cells in B - cell acute lymphoblastic leukemia

Possible modes of hierarchy alteration are suggested as increased self - renewal (a), dedifferentiation of early progenitor cells (b), and blocked proliferation (c) of ER - α — positive and negative tumors.

These cells, along with dendritic cells, recognize the incoming undigested food particles, toxic agents, and bacterial components as foreign invaders, and present them to cells of the adaptive immune system called T and B lymphocytes, leading to clonal expansion (proliferation or multiplication of specific subsets of T and B cells) and recruitment of more pro-inflammatory immune cells to the gut through a process called leukocyte homing.

These include a reduction in B cell differentiation to plasma cells and a reduced proliferation of T cells.