Sentences with phrase «b cell activity»

«Tolerating yourself: A novel pathway to regulate B cell activity and prevent autoimmunity.»

B cell activity is visible in green in the synthetic tissue (bottom right).

Not exact matches

«Ultimately, we needed 20 years to learn how to supercharge these cells to deliver anticancer activity,» says Arie Belldegrun, president and CEO of Kite Pharma in Santa Monica, California, which is assessing CAR T cells in six trials for B cell leukemia and lymphomas, and glioblastoma.

Beets also contain folate, a B complex vitamin, with a crucial role in cell regeneration, along with essential and trace minerals (manganese, magnesium, potassium, iron) with key detox activities in the body.

BOX 26, B -3-3; 30215360 / 734836 SAPA Reading Excerises, Activity of Rats, 1973 - 1974 Auto - Instructional, Point - to - Point, 1973 - 1974 Reading Excercises, Left Hand - Right Hand, 1974 Interpreting Data, Earth Maps and Mars Photos, 1974 Interpreting Data, Earth Maps and Mars Photos, 1974 Experimenting, I See, I See, 1974 Experimenting, Pressure and Volume, 1974 Operational Definitions, Flowers, 1974 Interpreting Data, Scientific Notation, 1974 Formulating Hypothesis, Optical Illusions, 1974 Experimenting, Interference in Learning, 1974 Experimenting, Density, 1974 Experimenting, Plants in Light, 1974 Interpreting Data, Things Look Bigger (Cells), 1974 Classifying, Six Legged Wonders, 1974 Experimenting, The Influence of Light on Plant Growth, 1974 Measure I & II, Testing Guides and Tests General Evaluation Questionnaire (4 Folders), 1971 - 1972

The current test is only able to analyze part of the human immune system, namely the B - cells but not the T - cells, which are needed as helper cells to fight the infection and whose activity indicates the presence of an infection.

Among the protagonists are B cells, which produce antibody molecules able to neutralize pathogens or mark them for destruction, and T cells, which prompt infected cells to kill themselves or secrete chemicals that direct the activities of other immune players.

The researchers also identified a molecular path by which Cbl - b blocks NK cell activity towards metastatic tumors.

«This suggests that MAO - B activity in peripheral blood cells of a patient might serve as an accessible and economical biomarker to evaluate the potential risk of an individual for this disease,» said Assoc Prof Lim.

The probe also has no apparent toxicity in most mammalian cells, so it can be used to monitor in vivo MAO - B activities during various stages of the disease.

The high MAO - B activity consistently observed in patients with Parkinson's disease has been proposed as a biomarker, but there has been a lack of suitable small molecule probes for MAO - B specific detection in live cells and tissues.

They report this month in the Proceedings of the Royal Society B that changes in the heartbeat due to temperature (the heart slows as it cools and then speeds back up as the fish resurfaces) and adrenaline, released from the stress of diving, alter the electrical activity of the heart cells to sustain the constant calcium cycling needed to keep the heart going.

Depletion of neutrophils blocks the recruitment of antigen non-specific cells into the liver without affecting the antiviral activity of hepatitis B virus - specific cytotoxic T lymphocytes.

Targeting IFN - alpha to B cell lymphoma by a tumor - specific antibody elicits potent antitumor activities.

Depletion of neutrophils blocks the recruitment of antigen - nonspecific cells into the liver without affecting the antiviral activity of hepatitis B virus - specific cytotoxic T lymphocytes.

Our data suggests that targeting DGKζ could prove to be a more useful clinical approach to augment cytotoxic T cell activity against tumor than targeting Cbl - b, perhaps resulting from enhanced Ras / ERK signaling.

Recently, interest has developed regarding the possibility of targeting intracellular inhibitory proteins to improve T cell activity against cancer, including diacylglycerol kinase ζ (DGKζ)(9, 10) and Casitas b - lineage proto - oncogene b (Cbl - b)(11), which attenuate signal transduction events downstream of the TCR and CD28.

Title: Hematopoietic Stem Cell Function and Survival Depend on c - Myc and N - Myc Activity Authors: Laurenti E, Varnum - Finney B, Wilson A, Ferrero I, Blanco - Bose WE, Ehninger A, Knoepfler PS, Cheng PF, MacDonald HR, Eisenman RN, Bernstein ID, Trumpp A Date: 2008 Publication Details: Cell Stem Cell, Volume 3, Issue 6, 611 - 624, 4 December 2008

Individual components of the ERG waveform (a-wave, composite b - wave, cone b - wave and rod b - wave) reveal relative contributions of different retinal cells to the overall functional activity of the retina.

This indicates that MAIT cells are probably involved in the host response at the site of pathogen entry, and may regulate intestinal B - cell activity.

(C, D) HepG2 cells were transfected and replated in 96 - well plates as described in B, but treated with compounds at indicated concentrations (µM) overnight prior to determining luciferase activity.

Johannes Scheid, awarded for hos essay in the category Translational Medicine: «HIV Specific B cell Response in Patients with Broadly Neutralizing Serum Activity»

The B - cells have multiple immune functions, the main ones being antibody production, antigen presentation and regulation of the function and activity of other immune cells, i.e. T - regulatory cells, NK cells and macrophages [16].

PTPN22 is involved in the formation of a key protein known as lymphoid tyrosine phosphatase (LYP), which helps control the activity of T and B cells in the immune system.

Furthermore, we determined that RIPK2 inhibitor 1 effectively inhibited KHM2 cells at an approximate IC50 of 5 — 10 nM, and kinase activity was somewhat sensitive to detergent conditions (Fig. 4, B and C).

Researchers at Penn State College of Medicine, working with Chinese and American colleagues, have discovered a novel way to enhance and restore cancer suppressor activity in B - cell acute lymphoblastic leukemia, resulting in better outcomes in a pre-clinical model of the disease.

1994 saw her as Head of the Department of Transplantation Immunology at the CLB, in Amsterdam, and in 1999 she became Head of the department of the Immunology of the Laboratory of Vaccine Research of the National Institute of Public Health and Environmental Protection (RIVM), in Bilthoven, where her research activities focused on defining immunological correlates of protection on the T and B cell level after natural infection and vaccination.

Current research applications focus on new approaches to a) drug and probe development for neurodegenerative disorders and diseases including Schizophrenia, Alzheimer's, and Parkinson's, b) understanding the structural determinants of antidepressant binding to neurotransmitter transporters, c) cardiac arrhythmia as caused by the complex interplay of potassium channel regulation and drug interactions, d) multidrug resistance in cancer and bacterial cells related to multidrug transporter proteins, and e) structural basis of viral infections and antibody activity.

B, breast cancer cells are hierarchically organized and contain primitive CSC, early progenitor cells with some limited in vivo and in vitro stem cell activity, transit - amplifying cells, and more differentiated cells.

At body temperature of 39.8 ℃ (about 104 degrees Fahrenheit) maintained for a period of six hours, whole body hyperthermia «can increase the activity of T - and B - lymphocytes and the anti-tumor activity of... NK cells, and can facilitate the redistribution of the body's white blood cells to improve the monitoring function of the body's immune system.»

Probiotic supplementation has been shown to strengthen the activity of many cytokines — increasing interleukin (IL)-1 β and IL - 18 activates IFN - γ production from T, B, and Natural Killer Cells, which enhances phagocytosis (destruction) of pathogens.

Its properties can protect the body from infections by stimulating antibody activity, which include B cells, T - cell function and macrophages (all important to fighting viruses and bacteria).

In addition, since CGF is related to the nucleic acid it also increases the activity of the most important cells of human immune system (T - and B - cells) which fight with viruses or cancer cells.

Greater scores on the first principle component (PC1) were inversely associated with CD56 (Natural Killer Cells) and positively associated with CD4 (T helper cells) and CD19 (B or T helper cells), suggesting a relationship to both innate and acquired immune system actiCells) and positively associated with CD4 (T helper cells) and CD19 (B or T helper cells), suggesting a relationship to both innate and acquired immune system acticells) and CD19 (B or T helper cells), suggesting a relationship to both innate and acquired immune system acticells), suggesting a relationship to both innate and acquired immune system activity.