Sentences with phrase «b cell diseases»

But little is known about how B cell metabolism adapts to each of these environments, insights that may improve our understanding of B cell diseases, such as non-Hodgkin's lymphoma.

Some dogs with T cell disease achieve durable remissions, and some patients with B cell disease do not.

Not exact matches

In March, the U.S. Food and Drug Administration (FDA) approved BLINCYTO for the treatment of adults and children with B - cell precursor acute lymphoblastic leukemia in first or second complete remission with minimal residual disease (MRD) greater than or equal to 0.1 percent.

Pumpkin seeds are B - vitamin (needed for cell metabolism) and magnesium (playing a role in maintaining strong bones and reducing risk of metabolic syndrome — i.e. what can lead to heart diseases, stroke, and hypertension) powerhouses.

Conveniently, pure orange juice is also a source of the B - vitamin folate, needed for white blood cells (that protect the body against infectious disease) to rapidly reproduce.»

Breech Twins and higher order multiples Previous CS Pre-Eclampsia Placenta praevia Cervical incompetence Previous late stillbirth Previous premature birth Grand multiparty Age under 18 Age over 35 Smoking Drug use Severe mental health issue Epilepsy Type 1 diabetes Type 2 diabetes Gestational diabetes Asthma GBS positive Abnormal antibodies Transplant recipient Congenital heart disease Known foetal abnormality Immunosuppressive medication MS Physical disability Intellectual disability Hypothyroidism Hyperthyroidism Previous shoulder dystocia Previous 3rd or 4th degree tear Sickle Cell anaemia BMI under 18 or over 35 at conception Previous massive PPH APH in current pregnancy HIV / AIDS Hepatitis B or C Active TB IUGR Oligohydramnios Polyhydramnios Child previously removed from custody because of abuse Uterine abnormalities such as uterine septum or double uterus Previous uterine surgery for fibroids Chronic renal problems Hypertension Auto immune condition Previous stroke or blod clot Cancer Domestic violence or abusive home Prisoners Homeless women

(borrowed from Dr Kitty) Breech Twins and higher order multiples Previous CS Pre-Eclampsia Placenta praevia Cervical incompetence Previous late stillbirth Previous premature birth Grand multiparty Age under 18 Age over 35 Smoking Drug use Severe mental health issue Epilepsy Type 1 diabetes Type 2 diabetes Gestational diabetes Asthma GBS positive Abnormal antibodies Transplant recipient Congenital heart disease Known foetal abnormality Immunosuppressive medication MS Physical disability Intellectual disability Hypothyroidism Hyperthyroidism Previous shoulder dystocia Previous 3rd or 4th degree tear Sickle Cell anaemia BMI under 18 or over 35 at conception Previous massive PPH APH in current pregnancy HIV / AIDS Hepatitis B or C Active TB IUGR Oligohydramnios Polyhydramnios Child previously removed from custody because of abuse Uterine abnormalities such as uterine septum or double uterus Previous uterine surgery for fibroids Chronic renal problems Hypertension Auto immune condition Previous stroke or blod clot Cancer Domestic violence or abusive home Prisoners Homeless women

«Ultimately,» he says, «this approach could potentially be applicable to any autoimmune disease that has a B - cell component.»

«So there has been a lot of interest in the diabetes research community: If you can target those antigen - presenting B - cells, that could be potentially a very effective disease intervention,» says JAX Professor David Serreze, Ph.D., lead author of a highlighted study published in the Journal of Immunology.

Porter will also monitor the patients» long - term health; since they lack healthy B cells, they may require lifelong immunoglobulin to help resist other cancers, immune disorders, and infectious disease.

«If you want to develop a therapy for autoimmune diseases, the idea is, How do we get Xist to the inactive X chromosome and keep it there so we maintain dosage compensation in these B cells.»

A clinical trial has shown that patients with a specific molecular subtype of diffuse large B - cell lymphoma (DLBCL) are more likely to respond to the drug ibrutinib (Imbruvica) than patients with another molecular subtype of the disease.

Meanwhile Coussens and her colleagues at U.C.S.F. found in a 2005 study, published in Cancer Cell, that the removal of antibody - making B cells from mice engineered to be prone to skin cancer prevented the tissue changes and angiogenesis that are prerequisites for disease progression.

The team led by Professor Bozec turned off the oxygen sensor HIF in B cells and observed that this prevented the resolution of inflammation, leading to chronic inflammatory diseases.

«This suggests that MAO - B activity in peripheral blood cells of a patient might serve as an accessible and economical biomarker to evaluate the potential risk of an individual for this disease,» said Assoc Prof Lim.

The probe also has no apparent toxicity in most mammalian cells, so it can be used to monitor in vivo MAO - B activities during various stages of the disease.

The high MAO - B activity consistently observed in patients with Parkinson's disease has been proposed as a biomarker, but there has been a lack of suitable small molecule probes for MAO - B specific detection in live cells and tissues.

To make the vaccine, researchers took a sample of a patient's tumors, which in this trial were made up of B cells (white blood cells that help the body battle disease and infection).

«If you have a spontaneous disease, you have only a short window of time where you can get [ASCs],» he says, «so targeting memory B cells [from someone who has beaten the illness] may be an advantage.»

In fact, TBK1 may also be a contributor to debilitating diseases such as ALS (Lou Gehrig's disease) and childhood herpes simplex virus encephalitis, if its connection with ICOS somehow triggers B cell activation and specific antibody production against the body's own cells in ALS or an excessive response to the invading viruses in childhood encephalitis.

CAAR - T cells may provide an effective and universal strategy for specific targeting of autoreactive B cells in antibody - mediated autoimmune disease.

When given to diseased mice, the engineered T cells targeted and killed B cells that express antibodies targeting desmoglein 3, hinting that such a strategy may be an effective way to treat antibody - driven autoimmune diseases.

Here, we show that in the antibody - mediated autoimmune disease pemphigus vulgaris (PV), autoantigen - based chimeric immunoreceptors can direct T cells to kill autoreactive B lymphocytes through the specificity of the B cell receptor (BCR).

Along the way, the experiments have resulted in important information on how MS attacks the body, says Stephen Hauser, a neurologist at the University of California, San Francisco, whose lab spent decades determining the critical role B - cells play in the disease.

Whereas traditional MS medications target the immune system's T - cells, ocrelizumab focuses on destroying the system's B - cells, which fuel the brain inflammation that causes the disease to worsen.

«It's not yet clear whether or how GSK3 might be a target for future therapies for B cell - related diseases, but this research opens a lot of doors for further studies,» Rickert said.

Monitoring the levels of GARP on B cells may provide a very useful diagnostic marker for autoimmune disease.

«We thought we could adapt this technology that's really good at killing all B cells in the body to target specifically the B cells that make antibodies that cause autoimmune disease,» said Milone.

Additionally, a form of indolent B cell lymphoma, which progresses slowly with only mild symptoms, can transform without warning into an aggressive form of the disease.

Payne researches autoimmunity, and a few years ago, a postdoctoral researcher in her laboratory, Christoph T. Ellebrecht, MD, took an interest in CAR T cell technology as a potential weapon against B cell - related autoimmune diseases.

«In a nutshell, what we found is that this gene has an effect on the frequency of these T follicular helper cells, which are important for the B cells and seem to be important for the disease,» says Dr. Kissler, who is also an assistant professor of medicine at Harvard Medical School.

«Overall, the T follicular helper cells are important for B cells, you have more of those T cells in people with type 1 diabetes, they seem to be very important for the disease, and we have a new explanation of why RGS1 has been implicated,» Dr. Kissler sums up.

B could work as a potential vector for gene therapy, a technique that treats diseases by introducing new genes into cells or by replacing or inactivating genes already there.

(B) Example of this theoretical construct applied to sickle cell disease.

Among other applications, its innovative technological platform enables identifying and analyzing the genetic diversity of B cells to convert them into polyclonal recombinant antibodies (biotherapeutics) that improve outcomes for patients with severe diseases.

Murine gammaherpesvirus 68 infection of IFNγ unresponsive mice: a small animal model for gammaherpesvirus - associated B - cell lymphoproliferative disease.

It turns out that rituximab can also work for diseases such as rheumatoid arthritis, multiple sclerosis and other autoimmune conditions in which overactive B cells in the immune system contribute to the inflammation and degradation of healthy tissue.

Endari, the first new treatment for patients with sickle cell disease in almost 20 years, Genentech's Hemlibra, the first - ever non-blood product to treat patients with hemophilia A with inhibitors, Actemra, the first treatment for adults diagnosed with giant cell arteritis, BioMarin's Brineura, the first treatment for a form of Batten disease, Benznidazole, the first U.S. treatment for Chagas disease, Novartis» Kymriah to treat certain children and young adults with B - cell acute lymphoblastic leukemia, which is also the first gene therapy to become available in the United States, are some of the drugs that received the FDA's stamp of approval in 2017.

B cells (bursal or bone marrow - derived cells) are lymphocytes that play a pivotal role in the adaptive immune system and disruption of B cell function is a common hallmark of many different diseases.

NEMO / IKK: Targeting the interaction between NEMO and IKK to block pathological NF - kB signaling has many therapeutic applications in inflammatory and autoimmune diseases (RA, IBD, psoriasis, acute inflammatory indications, etc.) and oncology (immuno - oncology, B - cell lymphomas, and solid tumors).

The study relates to a particular type of vaccine (killed) against a particular virus, influenza, though the findings might hold true for other killed vaccines and for those vaccines consisting only of proteins produced by GM in bacteria, yeast or insect cells, against diseases such as hepatitis B (HBV) and human papilloma virus (HPV, the causative agent of cervical cancer).

BIIB054 was originally developed by biotech company Neurimmune, using a platform they call Reverse Translational Medicine (RTM ®), which derives therapeutic antibody candidates from libraries of de-identified B - cells isolated from ostensibly healthy older adults (those free of specific neurological diseases of aging).

Smith MR, Syed A, Lukacsovich T, Purcell J, Barbaro BA, Worthge SA, Wei SR, Pollio G, Magnoni L, Scali C, Massai L, Franceschini D, Camarri M, Gianfriddo M, Diodato E, Thomas R, Gokce O, Tabrizi SJ, Caricasole A, Landwehrmeyer B, Menalled L, Murphy C, Ramboz S, Luthi CR, Westerberg G, Marsh JL.A potent and selective Sirtuin 1 inhibitor alleviates pathology in multiple animal and cell models of Huntington's disease..

• Patients must have adequate coagulation (international normalized ratio (INR) or prothrombin time (PT), partial thromboplastin time (PTT) ≤ 1.5 times ULN) • Adequate liver function (total bilirubin ≤ 1.5 times the ULN, alanine aminotransferase (ALT) and aspartate aminotransferase (AST) ≤ 2.5 times ULN Exclusion Criteria: • Presence of active / uncontrolled central nervous system involvement • History of clinically significant cardiac disease; uncontrolled hypertension • Left ventricular ejection fraction (LVEF) < 45 % • Allogeneic stem cell transplant within 100 days before first dose of study drug • Known history of human immunodeficiency virus (HIV) infection • Chronic or active hepatitis B or C, requiring antiviral therapy • Evidence of history of bleeding disorder, dialysis, or coexisting cancer that is distinct in primary site or histology from the cancer evaluated in this study • Serious, uncontrolled infection • Unresolved chronic toxicity > grade 1 from prior therapy • Use of strong CYP3A4 inhibitors or strong inducers within 7 days prior to the start of study treatment and for the duration of the study

T and B cell clonal expansion in Ras associated lymphoproliferative disease (RALD) as revealed by next generation sequencing

Altogether, these results indicate that the xenograft grew from the patient's Epstein - Barr virus - infected B - lymphoid cells and could be assimilated to posttransplant lymphoproliferative disease.

The results showed that the mutational spectrum of these genes in PTCL - NOS was similar to that in B - cell lymphoma, in which predominantly missense mutations were found.17, 18 Importantly, our study provided clinical evidence that histone modifier gene mutations, particularly those involved in histone methylation and acetylation, are significantly associated with tumor chemoresistance and disease progression of PTCL - NOS.

The presence of a clonal B - or T - cell population is highly indicative of a hematologic disease.

B - cell targeting therapy has been increasingly used for diverse autoimmune diseases in later years [15].

We did not identify the JAK2V617F disease allele in B - lineage ALL (n = 83), T - cell ALL (n = 93), or CLL (n = 45).