Sentences with phrase «b cell function»

Canine distemper virus is an immunosuppressive virus that affects both T and B cell function.

This can lead to their killing ability being disrupted, and can often cause problems with B cell function too.

Therefore, T cell immunodeficiencies can often lead to combined immunodeficiencies (CIDs), where both T and B cell function is defective.

B cells (bursal or bone marrow - derived cells) are lymphocytes that play a pivotal role in the adaptive immune system and disruption of B cell function is a common hallmark of many different diseases.

miR - 150 regulates obesity - associated insulin resistance by controlling B cell functions.

Not exact matches

The antioxidants in the squash prevent cell damage and vitamin B helps cells function better.

Pitaya is loaded with antioxidants including vitamin C to neutralize free radicals, and also magnesium — an important mineral needed for enzymatic reactions and for your cells to create energy, plus fiber and B vitamins — for healthy cognitive function and they help to convert your food to energy.

Made up of essential fatty acids and B vitamins, lecithin supports healthy function of the brain, nervous system and cell membranes.

Nursing Blend also contains extra amounts of Vitamins B - 6 and B - 12, which are necessary for the proper function of the immune system and nervous system and in the production of red and white blood cells.

As it turns out, B - cells play a major, and sometimes independent, role in immune function, dancing with T - cells in a fluid and Escher - like loop.

The protein has long been considered too complex to target with a drug as it also is crucial to proper function of many immune system cells, not just B cells gone bad.

Based on this work, they decided to investigate whether miR -17-92 regulates T - and B - cell differentiation and function in the development of cGVHD.

In the meantime, the MUSC team, led by Yu, will continue their work and try to extend the current findings by investigating how other miRs may be involved in regulating T - and B - cell function during allogeneic BMT.

Longitudinal Associations Between Ambient Air Pollution With Insulin Sensitivity, b - Cell Function, and Adiposity in Los Angeles Latino Children.

While analyzing molecules excreted by TRPV1 cells in search of anything that might be itch - specific, Hoon and his colleagues came across a small group of the neurons that produce natriuretic polypeptide b (Nppb), a hormone that regulates heart function and can also act as a neurotransmitter.

«While more work is required to elucidate the cellular and molecular mechanisms through which B cells exert their beneficial function in wound healing, we are in the process of obtaining the required regulatory approvals to conduct a first clinical study in patients with diabetic foot ulcers.

Colleagues of Ben - Ze «ev had examined the effect of turning off b - catenin on other, unrelated functions within cells.

Deletion or targeted inactivation of Cbl - b efficiently enhanced the anti-tumor function of NK cells.

Abd - B is essential for the positioning and function of the stem cell niche.

In humans, scientists know a lot about the cells involved in immediate antibody production, called plasmablasts, but less about the separate group of cells responsible for the «storage / research for the future» functions, called memory B cells.

Since B cells play a role in helping fight infection, patients typically receive immunoglobulin replacement to maintain healthy immune function.

«There are two types of T cells — CD8 and CD4 — which battle invading pathogens,» explains lead author Pablo Penaloza - MacMaster, PhD, a postdoctoral fellow in the Barouch laboratory and Instructor of Medicine at HMS «The CD8 T cells take the lead in eliminating virally infected cells while the CD4 «helper» T cells function indirectly, serving to bolster the responses of both CD8 T cells and antibody - producing B cells.»

GSK3 function is essential for B cell survival in germinal centers.

T, B, and NK cell counts and function, including antigen - specific responses, were comparable to those of age - matched controls.

After the artificial node had filled with antigen - specific T and B cells, Watanabe transplanted it into a mouse with no functioning immune system.

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In the study, vitamin B - 6 also was used to treat the damaged RPE cells producing healthy cells that functioned normally.

Now as an Assistant Professor in Medicine at Harvard Medical School, Daniel uses membrane structure and function as a means to define B cell antigen recognition and inform vaccine design.

«For instance, if you've got hepatitis B infection, then you're going to have impaired macrophage function in the liver, which is going to impair the ability of those cells to go on and respond to other viruses.

A motif found in numerous genes that are essential for the proper function of macrophages and B cells.

Patients with SLE generally have abnormal B - and T - cell function.

When Georgia Tomaras of Duke University Medical Center opened this year's HIV Vaccines Keystone symposium last night, she said this is the first ever HIV Vaccines meeting that is held jointly with a meeting on B cell development and function.

Title: Hematopoietic Stem Cell Function and Survival Depend on c - Myc and N - Myc Activity Authors: Laurenti E, Varnum - Finney B, Wilson A, Ferrero I, Blanco - Bose WE, Ehninger A, Knoepfler PS, Cheng PF, MacDonald HR, Eisenman RN, Bernstein ID, Trumpp A Date: 2008 Publication Details: Cell Stem Cell, Volume 3, Issue 6, 611 - 624, 4 December 2008

IRE1 function is especially critical in B cells since the ER plays a central role in the biogenesis of antibodies in response to immunization.

Rescue of this defect was due to proper localization and function of GFP - NMHC II - A in place of NMHC II - B in a cell - cell adhesion complex in the cells lining the spinal canal.

• Patients must have adequate coagulation (international normalized ratio (INR) or prothrombin time (PT), partial thromboplastin time (PTT) ≤ 1.5 times ULN) • Adequate liver function (total bilirubin ≤ 1.5 times the ULN, alanine aminotransferase (ALT) and aspartate aminotransferase (AST) ≤ 2.5 times ULN Exclusion Criteria: • Presence of active / uncontrolled central nervous system involvement • History of clinically significant cardiac disease; uncontrolled hypertension • Left ventricular ejection fraction (LVEF) < 45 % • Allogeneic stem cell transplant within 100 days before first dose of study drug • Known history of human immunodeficiency virus (HIV) infection • Chronic or active hepatitis B or C, requiring antiviral therapy • Evidence of history of bleeding disorder, dialysis, or coexisting cancer that is distinct in primary site or histology from the cancer evaluated in this study • Serious, uncontrolled infection • Unresolved chronic toxicity > grade 1 from prior therapy • Use of strong CYP3A4 inhibitors or strong inducers within 7 days prior to the start of study treatment and for the duration of the study

Although much is known regarding the specificity and efficacy of antibody responses, our knowledge of the function, phenotype, and specificity of the antigen - specific B cells that are responsible for antibody production, as well as for long - term humoral memory, is inadequate.

Lethal toxin also directly affects the function of T cells, B cells and NK T cells [36 — 39].

Our initial pursuit of the function of XBP - 1 led to surprising conclusions that XBP - 1 is not activated by misfolded antibodies and XBP - 1 plays minimal role in correcting misfolded proteins in B cells.

The B - cells have multiple immune functions, the main ones being antibody production, antigen presentation and regulation of the function and activity of other immune cells, i.e. T - regulatory cells, NK cells and macrophages [16].

Cobaleda, C., Schebesta, A., Delogu, A. & Busslinger, M. Pax5: the guardian of B cell identity and function.

They do, however, play a key role in helping to boost the anti-tumor immune response by: (1) expanding the number and improving the function of existing CTLs that are specific to the same tumor antigen; and (2) providing help to other immune cells, including B lymphocytes that are precursors to antibodies and natural killer (NK) cells that are also important in the overall anti-tumor immune response.

This CK2 inhibitor restored Ikaros function and resulted in a strong therapeutic effect in cancer cells from B - ALL patients.

In addition, they have a high concentration of choline and vitamins B - 12 and D, which play a pivotal role in maintaining your energy levels and proper cells function.

B - Complex also supports normal nerve cells function and the conversion of homocysteine, thus supporting normal heart function.

Carrots also contain fair amounts of vitamin B9 (folate), which is crucial for fetal development, as well as for iron absorption and red blood cells production; vitamin C (ascorbic acid), which improves immunity and promotes skin health by stimulating collagen formation; potassium, for the regulation of blood pressure, as well as for suporting muscle and nerve function; manganese, for calcium absorption, carbohydrates metabolism, and blood sugar regulation; B - complex vitamins, namely thiamin, niacin, riboflavin, and pantothenic acid, all of which are necessary for vital bodily functions; and copper, which not only promotes red blood cells production, but also supports vascular, nerve, immune, and bones health.

B vitamins, if you weren't sure, are essential for energy production in the cells, and normal nervous system function.

At body temperature of 39.8 ℃ (about 104 degrees Fahrenheit) maintained for a period of six hours, whole body hyperthermia «can increase the activity of T - and B - lymphocytes and the anti-tumor activity of... NK cells, and can facilitate the redistribution of the body's white blood cells to improve the monitoring function of the body's immune system.»

This green beauty has been known to increase red blood cell count to help boost immune system function [1] and it's b - complex vitamins are great for aiding digestion.

Its properties can protect the body from infections by stimulating antibody activity, which include B cells, T - cell function and macrophages (all important to fighting viruses and bacteria).