Sentences with phrase «b cell lineages»

Not exact matches

In this process, several hundred times more cells of the so - called myeloid lineage (thrombocytes, erythrocytes, granulocytes, monocytes) form than long - lived lymphocytes (T cells, B cells, natural killer cells) do.

The research team found that two distinct B - cell lineage antibodies teamed up to stimulate the highly sought - after broadly neutralizing antibodies to HIV.

Relative to reactions on naked DNA, there are changes (protections and enhancements) in the reactivity of guanine residues to dimethyl sulfate within the enhancer sequence in myeloma, B, and early B cells, whereas virtually no alterations appear in cells of non-B lineage.

But only after engaging the target and adjusting their antigen receptors over many generations (as B cells do by mutating their antigen receptor genes) can this lineage of cells produce VRC26 bnAbs.

Thus, in principle, a successful vaccine has to stimulate the first B cells in this lineage and then coax them along a fairly narrow evolutionary path until they have changed enough to provide effective protection against HIV.

Andrabi therefore analyzed how B cells in the VRC26 lineage changed in CAP256's blood in the course of HIV infection.

All of the lymphomas involved the B - cell lineage and were further classified in most cases as centroblastic - centrocytic or centroblastic follicular B - cell lymphomas (Fig. 2C) ⇓.

Recently, interest has developed regarding the possibility of targeting intracellular inhibitory proteins to improve T cell activity against cancer, including diacylglycerol kinase ζ (DGKζ)(9, 10) and Casitas b - lineage proto - oncogene b (Cbl - b)(11), which attenuate signal transduction events downstream of the TCR and CD28.

The B cell depleted fraction was then surface stained for lineage markers (CD3, CD19, CD14), CD127 and cells were sorted (Lin - CD127 +).

We did not identify the JAK2V617F disease allele in B - lineage ALL (n = 83), T - cell ALL (n = 93), or CLL (n = 45).

In contrast, we did not identify JAK2V617F mutations in B - lineage ALL (83 patients), T - cell ALL (93 patients), or CLL (45 patients).

In this report, we identified JAK2V617F mutations in a subset of CMML / aCML, AML, and MDS but not in B - lineage ALL, T - cell ALL, or CLL.

We used direct sequence analysis to determine if the JAK2V617F mutation was present in acute myeloid leukemia (AML), chronic myelomonocytic leukemia (CMML) / atypical chronic myelogenous leukemia (aCML), myelodysplastic syndrome (MDS), B - lineage acute lymphoblastic leukemia (ALL), T - cell ALL, and chronic lymphocytic leukemia (CLL).

CpG stimulation of precursor B lineage acute lymphoblastic leukemia induces a distinct change in costimulatory molecule expression and shifts allogeneic T cells towards a Th1 response.

(B) Percent of sorted single HES3 cells in (A) expressing stem or lineage markers according to level of surface marker expression.

(B) Percent of isolated single cells expressing stem or lineage markers according to location with the colony.

While this approach did not allow us to examine the impact of selective EBI2 - deficiency in DCs on WT B - lineage cells, the experiment did allow assessment of the response of EBI2 - deficient B cells in mice that lack EBI2 on CD11c + DCs while retaining EBI2 on approximately half of all non-CD11c expressing cells (such as helper T cells).