Sentences with phrase «b cell responses»

(A, B) Mixed (1:1) CD11cDTR (CD45.1 +) and Ebi2 - / - or Ebi2 + / + (CD45.1 ʱCD45.2 +) BM chimeric mice were immunized with SRBCs and flow cytometric analysis of B cell responses performed five days later.

National Institute of Environmental Health Sciences (NIEHS) Symposium B Cell Responses to Environmental Exposures Sunday, May 14, 8:00 AM — 10:00 AM, Room 204AB Chairs: Michael C. Humble, NIEHS, NIH Mary H. Foster, Duke Univ..

A number of studies have shown that DCs can directly augment B cell responses (MacPherson et al., 1999; Balazs et al., 2002; Jego et al., 2005; Qi et al., 2006).

IgDiscover uncovers genetic diversity in the immunoglobulin loci at the individual level, enabling an improved understanding of protective and pathogenic B cell responses in a variety of settings and facilitating future personalized immunization strategies.

These include: 1) live viral vaccine neutralization by maternal Abs, 2) Ab feedback mechanisms, 3) elimination of vaccine - antigen / maternal Ab immune complexes by phagocytosis, 4) inhibition of B cell responses through epitope masking, and 5) inhibition of B cell responses by binding of IgG to the FcγRIIB (134, 135).

The CD4 subset is capable of directing B cell responses and humoral immunity, and can modulate the actions of many other cell types including CD8 T cells, dendritic cells, macrophages, eosinophils, and basophils.

Alterations in peripheral blood B cell subsets and dynamics of B cell responses during human schistosomiasis.

This concept has been tested in the clinic to jump - start antigen - specific T and B cell responses.

Our findings provide insight into the human B cell responses to a pandemic influenza virus strain.

Relative importance of rotavirus - specific effector and memory B cell responses in protection against challenge.

B cell responses were examined in nine patients infected with the pandemic 2009 H1N1 influenza virus.

Type I interferon organizes several immune mechanisms to suppress B cell responses to a chronic viral infection.

A research group from the Department of Biomedicine at the University and the University Children's Hospital of Basel now discovered that innate lymphoid cells become activated and induce specific T and B cell responses during inflammation.

These findings are consistent with the observation that HIV Env immunization activates a highly polyclonal B cell response of substantial genetic diversity in NHP [55].

Broadly cross-reactive antibodies dominate the human B cell response against 2009 pandemic H1N1 influenza virus infection

Johannes Scheid, awarded for hos essay in the category Translational Medicine: «HIV Specific B cell Response in Patients with Broadly Neutralizing Serum Activity»

Not exact matches

KTE - C19 spurred either a complete or partial response in 13 out of 19 patients with large B - cell lymphomas.

But he added, «We need to improve the memory responses of T and B cells to make longer - lasting vaccines.»

Their results demonstrated shared mechanisms by which miR -17-92 mediates cGVHD progression — namely by regulating T helper - cell differentiation, B - cell activation, germinal center responses, and autoantibody production.

They demonstrated that non-obese diabetic (NOD) mice treated with a specific (AID / RAD51) pathway inhibitor had larger populations of certain B cells that were capable of suppressing diabetogenic T cell responses, and greatly reduced T1D development, compared with untreated controls.

«So, we not only found a new mechanism for cGVHD development by demonstrating that this miR -17-92 is heavily involved in the T - and B - cell responses that lead to cGVHD, but we also found that blocking miR - 17 substantially reduced cGVHD symptoms in mice.

To better understand how this abnormal distribution of B cell types in people with uncontrolled HIV affected their immune response to the virus, researchers compared HIV - specific antibodies derived from both TLM and RM B cells.

«What's remarkable is that B cells are the ones making antibodies and autoantibodies, so they're really crucial in both protective immune responses and autoimmunity,» said Montserrat C. Anguera, assistant professor in the Department of Biomedical Sciences in Penn's School of Veterinary Medicine and the senior author on the study.

This is because memory B cells, which remember antigens in the primary immune response, are induced and respond faster in the secondary exposure to bacteria or viruses and differentiate into antibody - producing cells.

Different clonal memory cell populations had different B cell or macrophage helper compositions that matched effector cell populations generated much earlier in the response.

DLBCL originates from B cells, which play a crucial role in the body's immune response.

Treatment with an investigational CAR T - cell therapy induced complete remission of a brain metastasis of the difficult - to - treat tumor diffuse large - B - cell lymphoma (DLBCL), which had become resistant to chemotherapy — the first report of a response to CAR T - cells in a central nervous system lymphoma.

The drug Rituxan, a monoclonal antibody that represses B cells in rheumatoid arthritis and B cell lymphoma, might prevent the inflammatory response that fuels formation of solid tumors.

To fend off HIV, researchers introduced one vaccine (ALVAC - HIV) to induce a T cell response — thereby alerting the immune system — and another (AIDSVAX B / E) later to spur an antibody response.

In the so - called humoral response, B - cells begin to secrete specific antibody proteins, which latch onto and neutralize pathogens in tissue or blood.

But in truth, most (26 of 28 vaccines currently licensed for human use) stimulate primarily a B - cell or antibody response, which in many cases is sufficient.

T and B cells are vital players in the immune system; their job is to circulate through the body, find infectious agents, and mount a protective response.

T cells and B cells reside there, and that's where you need to get the vaccine to get an immune response.

These animals had severely reduced T and B cell immune responses.

In a paper published in the journal Proceedings of the National Academy of Sciences, Sangeeta Bhatia of MIT and Charles Rice of Rockefeller University describe using microfabricated cell cultures to sustain hepatitis B virus in human liver cells, allowing them to study immune responses and drug treatments.

In fact, TBK1 may also be a contributor to debilitating diseases such as ALS (Lou Gehrig's disease) and childhood herpes simplex virus encephalitis, if its connection with ICOS somehow triggers B cell activation and specific antibody production against the body's own cells in ALS or an excessive response to the invading viruses in childhood encephalitis.

The rearrangements allowed Ellebedy and his colleagues to track the activated B cells, like DNA bar codes, as an immune response progresses.

The new technique, pioneered by Wilson and fellow researchers at the Emory University School of Medicine in Atlanta, saves time by using antibodies produced by so - called B cells (white blood cells that produce and then ferry them to infection sites to battle invading germs) in response to vaccines instead of to actual infections.

They found substantial differences following influenza vaccination in the production of immune - modulators that determine the type of T - cell response and in the proliferation and production of antibodies by B cells.

Further experiments confirmed that these increases in IgT and IgT - producing B cells were specific to the gills and not the result of a systemic increase in production, showing for the first time that a non-mammalian species can locally induce a dedicated mucosal immune response.

Antibody responses are initiated in lymph nodes close to the site of initial infection (so - called draining lymph nodes, or DLNs), where antigen - presenting cells, helper T cells, and antibody - producing B cells migrate to and interact to form so - called «germinal centers» and produce a highly specific antibody response.

The scientists demonstrated that B cells from healthy people also squirt out DNA in response to the distinctive molecular patterns that occur in many bacteria and viruses.

«There are two types of T cells — CD8 and CD4 — which battle invading pathogens,» explains lead author Pablo Penaloza - MacMaster, PhD, a postdoctoral fellow in the Barouch laboratory and Instructor of Medicine at HMS «The CD8 T cells take the lead in eliminating virally infected cells while the CD4 «helper» T cells function indirectly, serving to bolster the responses of both CD8 T cells and antibody - producing B cells.»

Because CD4 + (helper) T cell responses have been shown to be sufficient for protection from WNV challenge (independent of B cells and CD8 + T cells) and crucial for viral clearance from the CNS, the researchers focused on the WNV - specific CD4 + T cell repertoires present in the blood samples.

Fish that survived infection also had a significant increase in IgT - producing B cells in their gills, an additional sign that the IgT response was a key to fighting the parasite.

Sometimes when the immune system makes small mistakes, the body amplifies its response in a big way: Editing errors in the DNA of developing T and B cells can cause blood cancers.

They say this delayed response tallies with the idea that CFS is caused by autoantibodies — antibodies, made by B cells, that mistakenly attack the body's own tissues.

T, B, and NK cell counts and function, including antigen - specific responses, were comparable to those of age - matched controls.

The b cells secreted insulin, the team found, and adding sugar to their media made the b cells spew out more than twice as much of the hormone, just as b cells in the body release insulin in response to sugar.

Without Caveolin - 1, the binding of viruses or bacteria to the B cell results in a reduced activation signal, which leads to a weakened immune response.