The HZI will develop a
vaccination protocol for mucosal administration based on three novel
strategies: (i) development and optimization of a
vaccination protocol in which parenterally - primed T and
B cells are subsequently pulled into the mucosa by the local delivery of the cognate antigen to the requested effector site, (ii) testing the co-administration of antigens with novel mucosal adjuvants using different mucosal immunisation routes and schedules, and (iii) testing various nanoparticles co-administered with different immunomodulators for their ability to generate both systemic and mucosal immune responses following transcutaneous / trans - follicular
vaccination.