Sentences with phrase «b7 costimulatory»

Decreased expression of B7 costimulatory molecules and major histocompatibility complex class - I in human hepatocellular carcinoma.

Not exact matches

Insight into this mechanism led the researchers to design new peptides — snippets of the human B7 - 2 receptor protein — that powerfully block the binding of a superantigen to its costimulatory receptor targets, and thereby protect against lethal toxic shock, as they showed in animals.

Newly - discovered mechanism of action of the bacterial superantigen toxins: Superantigens bind to both B7 - 2 and CD28, the major costimulatory receptors expressed on human immune cells.

Tseng S - Y, Otsuji M, Gorski K, Huang X, Slansky JE, Pai SI, Shalabi A, Shin T, Pardoll DM, Tsuchiya H. B7 - Dc, a new dendritic cell molecule with potent costimulatory properties for T cells.

B7h, a novel costimulatory homolog of B7.

Costimulatory B7 - H1 in renal cell carcinoma patients: Indicator of tumor aggressiveness and potential therapeutic target.

When TLRs are triggered by lipopolysaccharides, oral Langerhans cells upregulate expression of coinhibitory molecules B7 - H1 and B7 - H3, whereas expression of the costimulatory molecule CD86 (B7 - 2) is decreased.

Costimulatory molecule B7 - H1 in primary and metastatic clear cell renal cell carcinoma.

Dr. Sharpe's functional analysis of costimulatory pathways regulating T cell activation has led to understanding of (1) the roles of B7 - 1 and B7 - 2 as positive regulators through CD28 and (2) negative regulators through CTLA - 4, and (3) the role of PD - L1 and PD - L2 as negative regulators through PD - 1.