Sentences with phrase «braf point mutations»

The distinction between these two pathways may help to explain the difference between outcomes for younger and older patients — PA in younger patients is more likely to be caused by K: B fusion and 5 - year survival is generally high; PA in older patients is more likely to be caused by BRAF point mutations and 5 - year survival is generally lower.

Not exact matches

In fact, there are two specific mechanisms for activation of BRAF implicated in PA formation: by fusion of the gene with nearby gene KIAA1549 (K: B fusion) or by point mutations of the BRAF gene itself.

She also points out that while the combination of dabrafenib and trametenib earned FDA approval against lung cancer with BRAF V600 mutation in the United States, the combination hasn't yet earned such approval in other countries, and these guidelines are meant to guide care not just in the United States, but internationally.