Sentences with phrase «bxd phenome»

For example, she studied brain activity and speech in a group of teenagers before, and three years after they entered high - school, and found music training in school significantly improved the auditory processing of phenomes (speech sounds) and had lasting effects on language skills.

By combining each mouse's genome, phenome, proteome and metabolome, the scientists were able to identify a particular gene, located on their chromosome 2, and whose presence plays an important role in the development of type 2 diabetes «The mice with a high - fat diet are more or less likely to develop diabetes depending on whether this gene is active or not,» said Evan Williams, LISP PhD student and the article's co-first author.

In Lausanne, the researchers carried out a detailed study of the genome and the «phenome» (the set of all phenotypes or clinical features) of a family of mice composed by 183 members.

That complexity perhaps explains why there is as yet no «human phenome project», though such a thing was first mooted in 2003.

Think about your own phenome.

But smaller - scale projects such as the Mouse Phenome Database are now springing up.

I haven't, so I am allowed into the lab's remarkable inner sanctum — the Phenome Room, a small windowless space the size of a studio apartment.

By going gene hunting in the Phenome Room, Jackson Laboratory scientists hope to steer their colleagues away from the search for single genes in favor of hunting for gene networks.

«These rich and large phenome data remain, however, largely unexploited, as they are difficult to access and the tools to analyze them require advanced skills,» says Johan Auwerx, whose lab at EPFL led the study with colleagues from Germany, Netherlands, and the US, as well as EPFL professors Kristina Schoonjans and Stephan Morgenthaler.

By now, the BXD community has gathered around 300 million phenotype data points from these animals, generating by far the largest coherent «phenome» (a set of all phenotypes expressed in an organism) for any animal experimental cohort.

In short, the BXD phenome is a perfect resource for modeling human populations for genetic studies.

The institute hosts one of the two nodes of the European Genome - phenome Archive (EGA).

The RD - Connect Genome - Phenome Analysis Platform distinguished as a recognized resource by the International Rare Diseases Research...

The ORDO and Human Phenotype Ontology (HPO) developers are working on integrating both ontologies and annotating Orphanet's phenome types with appropriate HPO terms (see also Monarch Initiative).

The CNAG - CRG plays a central role in the RD - Connect EU funded project through the development and hosting of the RD - Connect Genome - Phenome Analysis Platform.

The RD - Connect Genome - Phenome Analysis Platform, developed and hosted at the CNAG - CRG, securely integrates - omics data with clinical information, providing not only a centralized data repository but also a sophisticated and user - friendly online analysis system.

The project will also benefit from the RD - Connect Genome - Phenome Analysis Platform developed at CNAG - CRG; in this case, it will be used to collate existing and newly generated genomic and phenotypic data.

The RD - Connect Genome - Phenome Analysis Platform distinguished as a recognized resource by the International Rare Diseases Research Consortium.

ePheWAS, a way to identify associations between gene transcript or protein levels and phenome was updated.

The data stored on the Genome - Phenome Analysis Platform can be accessed only by the authorised scientists and clinicians who underwent the registration and verification process.

The CNAG - CRG hosts the RD - Connect Genome - Phenome Analysis Platform (https://platform.rd-connect.eu), which will be used in SOLVE - RD to collate existing and newly generated genomic and phenotypic data.

To learn more, see the Genome - Phenome Analysis Platform Registration Guide.

Thanks to recent advances in high - throughput phenotyping, the size and variety of the BXD phenome has increased exponentially since 2010, to ~ 5,000 quantitative clinical phenotypes as of December 2016 (Figure 2, detailed list could be downloaded here).

These webtools make use of the multilayered datasets from the BXD mouse population to expedite in silico gene function prediction through a series of integrative and complimentary systems analytical approaches, including (expression - based) phenome - wide association, transcriptome - / proteome - wide association, and (reverse --RRB- mediation analysis.

Phenome — Since the first publication on the BXDs, well over 200 research groups have generated behavioral, neurological, pharmacological, immunological, and more recently, metabolic phenotypes for this family.

The webtools make use of the multilayered datasets from the BXD mouse population to expedite in silico gene function prediction through a series of integrative and complimentary systems analytical approaches, including (expression - based) phenome - wide association, transcriptome - / proteome - wide association, and (reverse --RRB- mediation analysis (Figure 1 - 2).

These include variant analysis and annotation tools as well as therapeutic prediction tools and gene - drug interaction resources, many of which are integrated in the Genome - Phenome Analysis Platform.

Wednesday, Oct. 18, 9:45 - 10:00 a.m., Room 330A, South Building Platform Presentation: Large - scale phenome - wide scan in twins helps identify candidate variants associated with seborrheic keratosis S. Hebbring, Marshfield Clinic Research Institute, et al

335/10: 30 DNA.Land: A community - wide platform to collect millions of genomes - phenomes.

131/5: 00 Phenome - wide association study provides biologic insights into the etiology of age - related macular degeneration.

To address this challenge, the International Mouse Phenotyping Consortium is creating a genome - and phenome - wide catalog of gene function by characterizing new knockout - mouse strains across diverse biological systems through a broad set of standardized phenotyping tests.

132/5: 15 Complex diseases are associated with variation in Mendelian genes: A phenome - wide study using Human Phenotype Ontology and a population genotyped on the Exome BeadChip.

Thursday, Oct. 19, 5:45 - 6:15 p.m., Room 330C, South Building Invited Presentation: Assessing the phenome - wide consequences of genetically regulated molecular traits H. Im, University of Chicago, et al

339/11: 30 A practical guide to drug discovery through phenome - wide association studies.

All short - read sequencing data have been deposited at the European Genome - phenome Archive (EGA, http://www.ebi.ac.uk/ega/), which is hosted by the EBI, under accession number EGAS00001000274.

A person that love being me I'm trying to find that Phenome... Read More

«Synthetic phonics... involves learning to pronounce the sounds (phenomes) associated with letters «in isolation».

The exhibition explores the psychological and emotional impact of artworks that, through concept or formal material qualities, hint at larger, elemental phenome