Sentences with phrase «blood hematopoietic stem»
Review of «Evaluating Interaction of Cord Blood Hematopoietic Stem Progenitor Cells with Functionally Integrated 3D microenvironments» from STEM CELLS Translational Medicine by Stuart P. Atkinson
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It's blood in a newborn baby's umbilical cord that's rich in a type of stem cell called hematopoietic progenitor cells (HPCs).
The stem cells are a particular type, called hematopoietic stem cells, that make blood cells.
Hematopoietic stem cells, that form mature blood cells, require a very precise amount of protein to function — and defective regulation of protein production is common in certain types of aggressive human blood cancers.
Other adult stems cells exist — such as hematopoietic stem cells, which can generate all types of blood cell and mesenchymal stem cells, which can turn into bone, fat and cartilage cells.
Researchers at Dana - Farber / Boston Children's Cancer and Blood Disorders Center report promising outcomes from a clinical trial with patients with a rare form of bone marrow failure who received a hematopoietic stem cell transplant (HSCT) after pre-treatment with immunosuppressive drugs only.
«Proper blood cell production is dependent on functioning hematopoietic stem and progenitor cells that are destroyed during conditioning procedures for transplantation or following bone marrow injury,» said the study's first author Kevin A. Goncalves, who performed this research as part of his PhD studies in cellular and molecular physiology at the Sackler School.
The blood ancestors are usually called hematopoietic stem cells; these cells were classically defined as a specific category of multipotent cells at the top of the hierarchy that can differentiate into any blood cell type by following a deterministic program.
In addition to suppressing the mature blood cells battling against the infection, malfunctioning of this signaling system results in permanent damage to the body's blood producing cells — called hematopoietic stem cells — that are located in the bone marrow.
Hematopoietic stem cells — bone marrow - derived adult stem cells that give rise to the wide variety of specialized blood cells — come in two flavors: the reserve force sits quietly waiting to be called upon while the active arm continually proliferates spawning billions of blood cells every day.
The findings, published today in Nature, demonstrate that these myeloproliferative neoplasias only appear after damage to the microenvironment that sustains and controls the hematopoietic stem cells — the cells that produce the cells of the blood and the immune system.
«Active HSCs (hematopoietic stem cells) form the daily supply line that continually replenishes worn - out blood and immune cells while the reserve pool serves as a backup system that replaces damaged active HSCs and steps in during times of increased need,» explains Li.
She then followed up with a closer look at role of the Igf2 signaling pathway in coaxing quiescent hematopoietic stem cells to start dividing and maturing into multi-lineage progenitors that ultimately give rise to specialized blood cells.
Through gene therapy, researchers engineered blood - forming stem cells (hematopoietic stem / progenitor cells, or HSPCs) to carry chimeric antigen receptor (CAR) genes to make cells that can detect and destroy HIV - infected cells.
Our blood is generated by blood - forming (hematopoietic) stem cells (HSCs) in the bone marrow.
In the case of blood stem cells (also called hematopoietic stem cells or HSCs), this can lead to blood cancers, a loss of blood cells and an impaired ability to fight disease.
Earlier mouse studies by Li and his collaborators had indicated that the expression of several imprinted genes changes as hematopoietic stem cells embark on their journey from quiescent reserve cells to multi-lineage progenitor cells, which form the many highly specialized cell types that circulate within the blood stream.
Hematopoietic stem cell transplantation (HSCT), once considered an effective yet risky alternative to drug therapy for blood cancer, has become more accessible and successful in a wide range of patients as a result of major advances in transplant strategies and technologies.
One example is the generation of different types of blood cells from their precursors, the hematopoietic stem cells.
Researchers have known that aberrations in the methylation of hematopoietic, or blood - forming, stem cells (HSCs) can prevent them from differentiating into mature blood cells, leading to AML.
Aging is a key risk factor for sAML because, over time, hematopoietic stem cells (which give rise to all other blood cell types) accumulate DNA mutations and changes in other molecules that put DNA instructions into action, such as RNA and proteins.
The five - year study, led by UCLA Jonsson Comprehensive Cancer Center member Dr. Jianyu Rao, measured the ability of TSY - 1 to affect telomerase activity in cancer cells lines, including one known as HL - 60, as well as normal peripheral blood mononuclear and hematopoietic stem cells.
These so - called hematopoietic stem cells (from Greek meaning «to make blood») have been reliably used over the past 40 years to seed bone marrow transplants in the treatment of some cancers and immune disorders.
Stowers researchers discovered that megakaryocytes directly regulate the function of murine hematopoietic stem cells — adult stem cells that form blood and immune cells and that constantly renew the body's blood supply.
Before September, researchers had pinned their hopes on adult hematopoietic stem cells — blood - producing stem cells.
The results make it clear, says stem - cell biologist Amy Wagers, who headed the study, that these hematopoietic stem cells can do a lot for blood diseases but not for diseases affecting other kinds of cells.
In the study, USC Stem Cell researcher Casey Brewer and colleagues in the laboratory of Rong Lu found that transplantation dose affects the behavior of blood - forming stem cells in bone marrow — called hematopoietic stem cells, or HStem Cell researcher Casey Brewer and colleagues in the laboratory of Rong Lu found that transplantation dose affects the behavior of blood - forming stem cells in bone marrow — called hematopoietic stem cells, or Hstem cells in bone marrow — called hematopoietic stem cells, or Hstem cells, or HSCs.
«We found that TRAF6 overexpression in mouse hematopoietic stem cells results in impaired blood cell formation and bone marrow failure,» said Starczynowski, a member of the Division of Experimental Hematology and Cancer Biology at Cincinnati Children's Hospital Medical Center.
Leukemia starts in the «hematopoietic» stem cells in the bone marrow that give rise to all the different kinds of mature blood cells.
Subsequently, the hematopoietic system has to be replaced with stem cells from the blood of a healthy donor.
Importantly, this genetic alteration did not affect normal hematopoietic (blood) stem cells.
The only curative treatment is a hematopoietic (blood - forming) stem cell transplant from a compatible donor.
The researchers focused on how hematopoietic stem cells developed into one of two types of white blood cells: macrophages or neutrophils.
The hematopoietic stem cells that last the lifetime of the organism form within nodes of the mesoderm that line the mesentery and the major blood vessels.
Artificial bones produce new blood cells in mice, obviating the need for irradiation to kill off resident hematopoietic stem cells in recipients.
But for blood cancer patients who receive donor hematopoietic stem cell transplants as part of their treatment, graft - versus - host disease (GVHD) often hampers their recovery.
One chapter describes the clear clinical applications of hematopoietic stem cells from cord blood.
During hematopoiesis, hematopoietic stem cells (HSCs)(also called hemocytoblasts) give rise to all the different types of blood cells.
The aorta - gonad - mesonephros (AGM) region in the aortic wall appears to be the most important source of new blood cells, and it has been found to contain numerous hematopoietic stem cells by day 11 of mouse embryonic development.
Hematopoiesis, where a single hematopoietic stem cell gives rise to the entire blood system, is an important model for differentiation with great medical importance.
Platelets (or thrombocytes) control the process of blood clotting and transfusions are common to prevent bleeding in treatments involving hematopoietic stem cell (HSC) and bone marrow (BM) transplantation [1].
Plerixafor in combination with granulocyte - colony stimulating factor (G - CSF) has been approved for hematopoietic stem cell mobilization to the peripheral blood in patients with non-Hodgkin's lymphoma and multiple myeloma [54].
While human cord blood represents a potentially important source of hematopoietic stem and progenitor cells (HSPC), current two dimensional (2D) growth conditions employed to amplify cell numbers to the level required for many regenerative applications lead to a decline in the absolute percentage of the most primitive HSPCs [1].
The FDA has approved the use of stem cell - based products, including cord blood - derived hematopoietic progenitor cells (blood forming stem cells) for many diseases.
Title: The combination of valproic acid and lithium delays hematopoietic stem / progenitor cell differentiation Authors: Walasek MA, Bystrykh LV, van den Boom V, Olthof S, Ausema A, Ritsema M, Huls G, de Haan G and van Os R Date: 2012 Publication Details: Blood 2012 Mar 29; 119 (13): 3050 - 59
Role of hematopoietic stem cells in steady state hematopoiesis It is remain not very clear if all blood cell types are developed from one hematopoietic stem cell (HSC) in normal hematopoiesis, because of limitations of conventional transplantation models.
The growth or production of hematopoietic stem cells (stem cells that give rise to all blood cell types) is known...
The Hematopoietic stem cell population resident in bone marrow is responsible for generating blood cells and immune cells.
Patients who receive HSCT receive high doses of chemotherapy, with or without radiation, followed by infusion of hematopoietic stem cells (HSCs)-- rare cells that reside within the bone marrow and are capable of producing all varieties of blood cells.
When undergoing treatment for leukemia many patients require hematopoietic stem cell (HSC) transplantation to replace the blood stem... Continue reading Mice pave the way to a cord blood transplant advance