Sentences with phrase «blood stem cells study»

«Blood stem cells study could pave the way for new cancer therapy.»

Not exact matches

Now, in a study published February 13 in Science Signaling, Lin's team discovered that a chemical compound that activates ATF6 also converts patient - derived stem cells into blood vessels.

This fits with studies we've conducted in the past in which we found that the gene primes blood stem cells for leukaemic transformation.»

He says the structure could also offer a new way of studying blood stem cells and how blood disorders arise.

Shane Mayack was a postdoc in the lab of Amy Wagers at Harvard University's Joslin Diabetes Center, studying blood stem cells.

In a study recently published in the journal Nature Biotechnology, HSCI researchers at Harvard University and Massachusetts General Hospital (MGH), in collaboration with Boston Children's Hospital and Dana Farber Cancer Institute, have developed a non-toxic transplantation procedure using antibodies to specifically target blood stem cells in mice, an approach they hope will make blood stem cell transplants for these patients far less toxic.

In this study, researchers took cells from patients with blood cancer MDS and turned them into stem cells to study the deletions of human chromosome 7 often associated with this disease.

«Proper blood cell production is dependent on functioning hematopoietic stem and progenitor cells that are destroyed during conditioning procedures for transplantation or following bone marrow injury,» said the study's first author Kevin A. Goncalves, who performed this research as part of his PhD studies in cellular and molecular physiology at the Sackler School.

Around 2000, then - postdoc Wagers and other researchers in Irving Weissman's and Thomas Rando's labs at Stanford revived the method, known as parabiosis, to study the fate of blood stem cells and muscle cells.

Some of the first evidence for cancer stem cells came from studies of leukemia in the 1990s, which showed that only a small subset of the cancerous blood cells could propagate the disease in mice.

Earlier mouse studies by Li and his collaborators had indicated that the expression of several imprinted genes changes as hematopoietic stem cells embark on their journey from quiescent reserve cells to multi-lineage progenitor cells, which form the many highly specialized cell types that circulate within the blood stream.

Dr Mohamed Elrayess, from ADLQ, said: «In this study we have shown that the impaired ability of fat stem cells to store excess fat was partially due to increased levels of the inflammatory marker interleukin - 6 in the blood.

A September 2002 follow - up study found no evidence for widespread transdifferentiation of blood - forming stem cells in brain, liver, kidney, gut and other tissues.

A study published January 4th in Cell Stem Cell demonstrates that a gene therapy approach can lead to the long - term survival of functional beta cells as well as normal blood glucose levels for an extended period of time in mice with diabetes.

The study was published in the December issue of Experimental Hematology, the official publication of the Society for Hematology and Stem Cells, and also highlighted in the journal's editorial due to its significance in the biology and treatment of blood cancer.

The five - year study, led by UCLA Jonsson Comprehensive Cancer Center member Dr. Jianyu Rao, measured the ability of TSY - 1 to affect telomerase activity in cancer cells lines, including one known as HL - 60, as well as normal peripheral blood mononuclear and hematopoietic stem cells.

A new test may reveal which patients will respond to treatment for graft versus host disease (GVHD), an often life - threatening complication of stem cell transplants (SCT) used to treat leukemia and other blood disorders, according to a study led by researchers at the Icahn School of Medicine at Mount Sinai and published online today in the journal Lancet Haematology and in print in the January issue.

This rejuvenated the stem cells in the bone marrow of the older mice that replenish their blood, and led to a wave of studies comparing the blood of old and young mice to try and identify the youth - giving substance.

The team could establish the number of white blood cell - generating stem cells by studying the pattern of mutations found within the blood cells.

The results make it clear, says stem - cell biologist Amy Wagers, who headed the study, that these hematopoietic stem cells can do a lot for blood diseases but not for diseases affecting other kinds of cells.

«The significance of this study expands beyond the limits of AHDS research, to the possibility of stem cell modeling the blood - brain barrier component in many other neurological diseases,» Vatine says.

In the study, USC Stem Cell researcher Casey Brewer and colleagues in the laboratory of Rong Lu found that transplantation dose affects the behavior of blood - forming stem cells in bone marrow — called hematopoietic stem cells, or HStem Cell researcher Casey Brewer and colleagues in the laboratory of Rong Lu found that transplantation dose affects the behavior of blood - forming stem cells in bone marrow — called hematopoietic stem cells, or Hstem cells in bone marrow — called hematopoietic stem cells, or Hstem cells, or HSCs.

In 2005, Rando and his colleagues published a study in Nature showing that stem cells in several tissues of older mice, including muscle, seemed to act younger after continued exposure to younger mice's blood.

The new Mount Sinai study reveals how loss of a protein called Sirtuin1 (SIRT1) affects the ability of blood stem cells to regenerate normally, at least in mouse models of human disease.

Early animal studies have shown that stem cells isolated from umbilical cord blood can stimulate cells in the spinal cord to regrow their myelin layers, and in doing so help restore connections with surrounding cells.

In a study recently published in the journal Scientific Reports, researchers in USF's Center of Excellence for Aging and Brain Repair say the results of their experiment are an early step in pursuing stem cells for potential repair of the blood - spinal cord barrier, which has been identified as key in the development of ALS.

According to a new study, these «cancer stem cells» reside in blood vessels.

Professor Haase also studies the relevance of genetic polymorphisms of DNA - repair and detoxification genes for AML and MDS, the relevance of iron overload for stem cell functions in MDS, and the establishment of FISH analysis of CD34 + cells from the peripheral blood as a diagnostic tool for screening and monitoring in patients with MDS.

Dr. Robert A.J. Signer, a postdoctoral research fellow in Dr. Morrison's laboratory and first author of the study, realized that this reagent could be adapted to measure new protein synthesis by stem cells and other cells in the blood - forming system.

In this study, prior to giving intensive BEAM chemotherapy (which uses carmustine, etoposide, cytarabine, and melphalan), researchers collected stem cells from each patient's blood.

Through the UCSD Clinical Cardiovascular Cell Therapy program, Dib and collaborating cardiology faculty plan to conduct clinical studies in a number of areas, including the effectiveness of adult stem cell transplant as a treatment for congestive heart failure; as a way to minimize heart damage after a heart attack; and in the formation of new blood vessels (angiogenesis) to increase blood flow to the heart for patients experiencing chest pCell Therapy program, Dib and collaborating cardiology faculty plan to conduct clinical studies in a number of areas, including the effectiveness of adult stem cell transplant as a treatment for congestive heart failure; as a way to minimize heart damage after a heart attack; and in the formation of new blood vessels (angiogenesis) to increase blood flow to the heart for patients experiencing chest pcell transplant as a treatment for congestive heart failure; as a way to minimize heart damage after a heart attack; and in the formation of new blood vessels (angiogenesis) to increase blood flow to the heart for patients experiencing chest pain.

Muscle damaged by heart attacks can be repaired by an injectable gel that forms scaffolding, attracting stem cells and blood vessels in a study that may lead to a new method for reducing heart failure.

Working with the research group led by Vijay G. Sankaran, M.D., Ph.D., of Boston Children's Hospital and the Broad Institute, Rajiv K. Khajuria, a doctoral student at Charité's Berlin - Brandenburg School for Regenerative Therapies, studied the molecular processes involved in the differentiation of stem cells and their development into mature blood cells.

«Enhanced cord blood stem cell transplants safe in long - term studies.»

In the second study, a team led by Shahin Rafii at Weill Cornell Medicine in New York City used adult mouse cells as their starting material, and then guided them through several steps — including exposure to some of the same gene - activating proteins — to create mature blood stem cells in a petri dish.

An innovative experimental treatment for boosting the effectiveness of stem - cell transplants with umbilical cord blood has a favorable safety profile in long - term animal studies, report scientists from Dana - Farber Cancer Institute, Beth Israel Deaconess Medical Center (BIDMC), and Children's Hospital Boston (CHB).

In a previous study by the same group 78, autologous culture - expanded MSC were infused to breast cancer patients to investigate whether MSC would enhance the engraftment of peripheral blood stem cells after myeloablative therapy.

The findings may even have implications for studying glioblastoma, a common brain cancer whose ability to grow, migrate and hack into the brain's blood supply appears to rely on a pattern of gene activity similar to that now identified in these neural stem cells.

In an NIH - funded study, scientists were able to direct human stem cells to form networks of tiny blood vessels that can connect to the existing circulation in mice.

Spreadsheet of 23 parameters for controlled studies treating cerebral palsy with stem cells from cord blood or bone marrow.

Her studies of the stem cells in bone marrow and their requirements for successful growth have contributed to advances in transplantation techniques that have saved the lives of patients with leukemia and other blood cancers.

To keep up to date with all the continuing studies that hope to boost the regenerative potential of cord blood, stay tuned to the Stem Cells Portal.

Until now, blood cell production was ascribed solely to bone marrow, but studies on mice have found that the majority of the body's platelets are produced in the lungs, as is a backup reservoir of blood stem cells that can step in when those in the bone marrow run dry.

To study blood development, researchers typically purify blood stem cells from the bone marrow of mice and transplant them into mice exposed to radiation, thus creating a tractable experimental system.

Doctors at Okyanos utilize a specifically developed Okyanos protocol for opening up the blood brain barrier to help deliver stem cells directly to the brain; a technique that has been proven effective in independent studies This enables doctors to target your stem cells inside the brain to re-establish blood flow and repair damaged nerve cells (neurons) as well as target the restoration of myelin, halting the future progression of symptoms.

In a study using human muscle tissue, scientists in Children's Stem Cell Research Center - led by Johnny Huard, PhD, and Bruno Péault, PhD - isolated and characterized stem cells taken from blood vessels (known as myoendothelial cells) that are easily isolated using cell - sorting techniques, proliferate rapidly and can be differentiated in the laboratory into muscle, bone and cartilage ceStem Cell Research Center - led by Johnny Huard, PhD, and Bruno Péault, PhD - isolated and characterized stem cells taken from blood vessels (known as myoendothelial cells) that are easily isolated using cell - sorting techniques, proliferate rapidly and can be differentiated in the laboratory into muscle, bone and cartilage ceCell Research Center - led by Johnny Huard, PhD, and Bruno Péault, PhD - isolated and characterized stem cells taken from blood vessels (known as myoendothelial cells) that are easily isolated using cell - sorting techniques, proliferate rapidly and can be differentiated in the laboratory into muscle, bone and cartilage cestem cells taken from blood vessels (known as myoendothelial cells) that are easily isolated using cell - sorting techniques, proliferate rapidly and can be differentiated in the laboratory into muscle, bone and cartilage cecell - sorting techniques, proliferate rapidly and can be differentiated in the laboratory into muscle, bone and cartilage cells.

A new study demonstrates that normal and leukemic blood stem cells fight for the same niche with consequences for cancer treatment and transplantation.

Utilizing sophisticated genetically engineered mouse models, we will study how these conserved longevity pathways regulate the homeostasis and aging of adult stem cells, including hematopoietic stem cells, the adult stem cells that sustain all blood lineages throughout life.

The study found that while peripheral blood stem cells may reduce the risk of graft failure, bone marrow may cut the chances of developing chronic graft - versus - host disease (GVHD), a complication that is frequently debilitating.