Sentences with phrase «borna virus sequences»

Can big data and genomic virus sequencing help us track emerging diseases, contain their spread and ultimately find antidotes for the next unknown pathology?

Identification of Ebola virus sequences present as RNA or DNA in organs of terrestrial small mammals of the Central African Republic

The viruses insert themselves into DNA repeats — patterns that occur in multiple locations throughout the genome, only one of which will carry the virus sequence, so tracking them down is time - consuming.

«Inference via virus sequences is less subject to biases than inference based on reported incidence data, particularly when public health systems collecting those data are overwhelmed,» Alizon said.

Chen and her colleague Guan - Zhu Han, an evolutionary biologist based at Nanjing Normal University, Nanjing, China, evaluated all dengue virus sequences from China available in the public database GenBank — about 1,000 - 4,000 samples each for the four dengue serotypes (DENV 1 - 4), for almost 10,000 total.

Software Dedicated to Virus Sequence Analysis «Bioinformatics Goes Viral» — Martin Hölzer — Advances in Virus Research — September 2017

Prof. Martin Hibberd: I have no direct conflict of interest, although I do have funding related to Dengue virus sequencing, with funding from various charities and commercial companies such as J&J and recent funding from the MRC Newton fund to sequence Zika viruses in Cape Verde.

Since this initial discovery, XMRV and MLV - related virus sequences resembling polytropic MLVs (P - MLVs) were also found in patients with chronic fatigue syndrome (CFS)[13], [14].

Mammary tumor virus sequences have not been detected in normal breast tissue or other tumors.

Not exact matches

Here's how it works: When a bacterium encounters DNA from a virus, it makes a strand of RNA, a molecular cousin to DNA, that matches the sequence of the viral DNA, known as a guide RNA.

Genetic sequencing by IAH scientists has, however, confirmed the two outbreaks sprung from the same virus, suggesting the culls and biosecurity measures failed to contain foot and mouth.

The researchers sequenced the HIV - 1 variants, and for each mother - infant pair, they tested the sensitivity of both transmitted and non-transmitted viruses to antibodies concurrently present in the mother's blood.

Many scientists also argue that destroying the stocks would do little to protect the world from smallpox, because it is now possible to recreate the virus from its genome, which was sequenced in 1994.

Fiers investigated the nucleotide sequence of the hemagglutinin gene of this duck virus and found that it was indeed very closely related to the strain that started the 1968 Hong Kong outbreak.

Genetic sequences of isolated flu virus are entered into a database, then published and made available for review by experts and the public.

Within a woman, the HPV16 virus had the same genome sequence across multiple body sites.

In addition to sequencing the woolly mammoth genome, Hendrik has reconstructed the diets of extinct giant sloths, debunked a hypothesis about the origin of human immunodeficiency virus (HIV) and sequenced the genome of the bacterium that caused Black Death.

Didier Raoult and his colleagues at the University of the Mediterranean in Marseille announced that they had sequenced the genome of the largest known virus, Mimivirus, which was discovered in 1992.

You need the oligonucleotides to stitch genes together, and as far as I know, most companies will check the order if the sequence represents that of a dangerous virus.»

An analysis of the HPV16 genome from 5,570 human cell and tissue samples revealed that the virus actually consists of thousands of unique genomes, such that infected women living in the same region often have different HPV16 sequences and variable risks to cancer.

In a study published in the May 29, 2014, edition of Molecular Ecology Resources, Duke researchers Peter Larsen, Ryan Campbell and Anne Yoder used high - throughput sequencing on sifaka blood samples to generate sequence data for more than 150,000 different sifaka antibodies — protective molecules that latch on to bacteria, viruses and other foreign invaders in the body and fight them off before they cause infection.

However, viral sequences found in genomes are often fossils of long - ago infections that can no longer reproduce independent virus particles that can then infect additional bacteria.

It's been over 30 years since scientists sequenced the first genome — that of a particular bacteria - infecting virus called bacteriophage fX174 — and they've only gotten better at it since then.

Sequence analysis of the virus revealed numerous genes previously thought to exist only in cellular organisms.

Joy: Yeah, but the point is we have the technology now to sequence and manufacture vaccines fairly quickly; and ideally they wouldn't be grown in eggs or whatever, right; because what if it starts as a virus in chickens or something, and we're screwed.

As is typical of newly isolated HIV viruses from Africa, the sequences did not match any HIV sequence then available on GenBank, the online database of genetic sequences maintained by the U.S. National Institutes of Health.

We hypothesized that they sometimes generate virus - like RNA sequences that can be detected by the immune system.»

CDC, racing to sequence the virus from those infected, said it's seeing «slight changes» in its genetic makeup, but, said Besser, agency scientists don't know what that means.

Data from in vivo mouse models indicate that delivery of the DMAb sequence for the influenza A-targeted monoclonal antibody protected against lethal doses of two very different, clinically relevant influenza A viruses.

«Our genomes are packed with sequences derived from viruses that were inserted many thousands of years ago, and these virus - like sequences can move around, causing genetic mutations and contributing to the evolution of our genomes.

In the first, standard testing that relied on genome sequencing had detected viruses in 10 of 14 patients.

Even matching the sequence of the simplest virus is stupendously unlikely.

An international team of influenza researchers in China, the United Kingdom and the United States has used genetic sequencing to trace the source and evolution of the avian H7N9 influenza virus that emerged in humans in China earlier this year.

Since then, he and his colleagues have modified the sequences of influenza viruses to bind to a natural microRNA expressed in humans and mice, in essence developing a virus that's knocked down by the body's natural microRNA.

Weiner, Elliott and colleagues studied the DNA sequences for two human monoclonal antibodies — one able to broadly target influenza A viruses and one able to broadly target influenza B viruses — with collaborators at Inovio and MedImmune.

The researchers compared the differences between the two sets of sequences to reconstruct how the H7N9 virus evolved through various species of birds and to determine the origin of genes.

Memish also told a press conference in Riyadh, Saudi Arabia, this week that the MERS virus has three new mutations compared to earlier sequences of the virus, reported Saudi Arabian newspaper Asharq (original article in Arabic).

«We hypothesized that virus - like DNA sequences inherent in our own genomes or the RNA transcripts they produce might be driving the production of interferon and contributing to disease,» said Dr. Crow, chair, Department of Medicine, and Benjamin M. Rosen Chair in Immunology and Inflammation Research at HSS.

Graham Hatfull starts his students even younger; he involves high school students and teachers in real research, isolating and sequencing bacteriophages — viruses that infect bacteria.

And now we have a potential target: parts of the genome that are found within all 100 strains of sequenced cold viruses.

We can get the complete genetic sequence of a virus, but nobody can tell you whether it's going to be able to transmit.

HPV is detected using a DNA analysis that looks for characteristic sequences from the 13 high risk strains of the virus in the cervical cell sample.

Although the polio sequence is freely available over the Internet and building the virus is not particularly challenging, many researchers condemned the paper's publication for needlessly raising fears among the public that scientists are offering instruction manuals to aspiring terrorists.

The intact virus is pretty redundant as a research tool: the genomes of many strains have been thoroughly sequenced and key proteins required by the functioning virus can be made in the lab.

We also sequenced 35 samples from suspected EVD cases that tested negative for EBOV; genomic analysis identified other known pathogens, including Lassa virus, HIV - 1, enterovirus A, and malaria parasites (fig.

The authors analyzed changes in the viral sequence and conclude that the current outbreak probably resulted from the spread of the virus from central Africa in the past decade.

We used massively parallel viral sequencing to understand how and when EBOV entered human populations in the 2014 West African outbreak, whether the outbreak is continuing to be fed by new transmissions from its natural reservoir, and how the virus changed, both before and after its recent jump to humans.

We sequenced 99 Ebola virus genomes from 78 patients in Sierra Leone to ~ 2000 × coverage.

And virus isolates are often sequenced months or years after they are collected — hardly the swift turnaround of a pandemic alert system.

Using high - throughput DNA sequencing, the researchers located mutations in bacterial genes that resisted the toxicity of growth inhibitors produced by bacterial viruses.