Sentences with phrase «brain gene expression»

Brain gene expression associated with depression differed markedly between men and women.

In addition to hinting at a link between depression and brain gene expression during development, there was also evidence of overlap between the genetic basis of depression and other mental illnesses.

Not exact matches

There's better communication,» she told Inc.com in an interview, citing science that shows meditation changes the brain, immune system, and even gene expression.

Neuroscientists have over the past decade uncovered evidence, both in rodent and human studies, that parental caregiving, especially in moments of stress, affects children's development not only on the level of hormones and brain chemicals, but even more deeply, on the level of gene expression.

Procured from algae, algal oil is source of DHA, an important long - chain omega - 3 that supports brain development, immune balance, and healthy gene expression.

Because this imprinting affects hundreds of genes that are non-coding, including microRNAs and non-coding RNAs, it's a very interesting fine - tuning mechanism for the dosage of gene expression in the brain and elsewhere in the body.»

By identifying gene expression signatures common to sight, touch and hearing, neuroscientists at the University of Geneva (UNIGE), Switzerland, discovered a sensory «lingua franca» which facilitates the brain's interpretation and integration of sensory input.

The activity of four transcription factors — proteins that regulate the expression of other genes — appears to distinguish the small proportion of glioblastoma cells responsible for the aggressiveness and treatment resistance of the deadly brain tumor.

«Our work suggests that fine - tuning messenger stability is an important mechanism orchestrating gene expression changes during normal brain development.»

They did this by testing tissue concentrations of fatty acids in liver, muscle and brain tissue, along with the expression of genes involved in regulating EPA status and its physiological benefits.

«We used the Allen Human Brain Atlas data to quantify how consistent the patterns of expression for various genes are across human brains, and to determine the importance of the most consistent and reproducible genes for brain function.&rBrain Atlas data to quantify how consistent the patterns of expression for various genes are across human brains, and to determine the importance of the most consistent and reproducible genes for brain function.&rbrain function.»

Research published this month in Nature Neuroscience identified a surprisingly small set of molecular patterns that dominate gene expression in the human brain and appear to be common to all individuals, providing key insights into the core of the genetic code that makes our brains distinctly human.

«It is exciting to find a correlation between brain circuitry and gene expression by combining high quality data from these two large - scale projects,» says David Van Essen, Ph.D., professor at Washington University in St. Louis and a leader of the Human Connectome Project.

Despite the anatomical complexity of the brain and the complexity of the human genome, most of the patterns of gene usage across all 20,000 genes could be characterized by just 32 expression patterns.

They compared the resulting gene expression patterns in all the parrot brains with neural tracing experiments in budgerigars.

By examining gene expression patterns, the new study found that parrot brains are structured differently than the brains of songbirds and hummingbirds, which also exhibit vocal learning.

Ronald Kahn and his colleagues at Harvard Medical School in Boston compared gene expression in brain samples from mice with type 1 or type 2 diabetes against those of healthy mice.

The researchers then compared the expression of all genes in six parts of the brain of the two bird species using state - of - the - art molecular techniques, including next - generation sequencing — the first time these tools have been used to find brain properties related to innovation and problem - solving in wild birds.

Scientists at The Scripps Research Institute (TSRI) have identified a molecule in the brain that triggers schizophrenia - like behaviors, brain changes and global gene expression in an animal model.

To find out, the duo decided to compare gene expression in astrocytes in the adult brain versus the aged brain in mice.

By deleting some of these «ultraconserved elements», researchers have found that these sequences guide brain development by fine - tuning the expression of protein - coding genes.

To develop a comprehensive view of astrocyte gene expression, the duo used the technique in four very different areas of the mouse brain: two regions of the cortex and the hypothalamus and cerebellum.

«The genes which these miRNAs regulate also had increased levels, indicating that these gene expression, indicating that these gene products were likely targeted for storage and for possible future use within the brain cell, rather than for destruction.

The researchers investigated 16 groups of female and male mice offspring exposed to maternal diet - induced obesity and male hormone excess and studied how these environmental factors affected the mice's behaviour as well as gene expression in the brain.

The environmental factors also affected gene expression in the brain.

The significance of the new model, according to Grange, is that «it enables us to now have a biological understanding of the patterns, the co-expression profiles, seen in the Allen Gene Expression Atlas of the Mouse Brain.»

If the gene expression profile of a neuronal type is measured, then the model predicts where in the brain that type of neuron can be found.»

Such a treatment might be combined with a gene therapy approach, also being pursued by her team and other groups, delivered directly to the brain to curtail mHTT expression.

The researchers discovered that this receptor mutation profoundly altered gene expression in neurons receiving dopamine at distal sites in the brain, specifically in the prefrontal cortex.

A molecule in cells that shuts down the expression of genes might be a promising target for new drugs designed to treat the most frequent and lethal form of brain cancer, according to a new study by researchers at The Ohio State University Comprehensive Cancer Center — Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC — James).

By comparing gene expression in the brains of resilient and avoidant mice, Berton and colleagues discovered that bullying in avoidant mice puts GABA neurons in a state where they become more excitable and the mice exhibit signs of social defeat.

Further, investigation of these CpG associations revealed nearby genes whose RNA expression was altered in brain samples with Alzheimer's disease: ANK1, CDH23, DIP2A, RHBDF2, RPL13, RNF34, SERPINF1 and SERPINF2.

Booij and her colleagues hope that this study will shed more light on the specific role of early environmental influences on brain development, gene expression and emotional regulation.

While previous investigations into the protein's effects have used either mice in which gene expression was knocked out or transgenic animals that expressed human gene variants throughout their lifetimes, the MGH - MIND - led study used a different approach to investigate the effects of introducing the variant forms of the protein into brains in which plaque formation had already begun.

It also remains unclear how knocking down expression of certain genes in zygotes via sperm miRNA leads to altered stress response in adult animals and altered gene expression in the brain.

We even did gene - expression studies in flies showing that genes in their brains change their level of activity in waking and in sleep.

The new research focused on just nine genes, those most strongly associated with autism in recent sequencing studies, and investigated their effects using precise maps of gene expression during human brain development.

«Using a technique developed by our collaborators at the University of Iowa, we were able to get long - term expression of these human gene variants in the fluid that bathes the entire brain,» says Bradley Hyman, MD, PhD, of the MassGeneral Institute for Neurodegenerative Disease (MGH - MIND), senior author of the report in the Nov. 20 Science Translational Medicine.

What we found is that the ability of this chronic social stress to produce maladaptive changes in brain and behavior — loss of pleasure, inability to sleep normally and so on — are mediated through epigenetic modifications of gene expression, in particular, emotional centers of the brain.

Nestler: The ability of this chronic social stress to produce maladaptive changes in brain and behavior are mediated through epigenetic modifications of gene expression in particular emotional centers of the brain.

During development, as an embryo forms differentiated tissues, liver cells, brain cells, muscle cells, the cells in those tissues begin to allow for the selective expression of genes contained in those same 3 billion nucleotides.

The brain attempts to adapt and respond to those challenges and that occurs in large part through changes in expression of brain genes through epigenetic mechanisms.

«TIA - 1 is known for its ability to regulate gene expression during cellular stress,» says Hewett, who studies the processes that suppress the severe electrical storms in the brain, leading to seizures.

However, the study showed the one area of the brain with the most human - specific gene expression is the striatum, a region most commonly associated with movement.

Despite differences in brain size, the researchers found striking similarities between primate species of gene expression in 16 regions of the brain — even in the prefrontal cortex, the seat of higher order learning that most distinguishes humans from other apes.

Finally they looked at gene expression in autopsied brains of individuals with Rett.

The article «A gestational diet high in fat soluble vitamins alters expression of genes in 1 brain pathways and reduces sucrose preference, but not food intake, in Wistar male rat offspring» by Sanchez - Hernandez et al. was published in the journal Applied Physiology, Nutrition, and Metabolism.

In post-mortem brains of 15 controls and 15 MDD subjects, the MDD group showed significant increase in the expression of miR -124-3p, and expression of three of the potential target genes was significantly lower.

The researchers in the Greenberg lab found that across all analyzed datasets, and in studies of different mouse brain regions, in the absence of MECP2 the expression of long genes is increased.

Then, they compared the patterns of gene expression in the resulting neurons with cells taken from autopsied brains.