Sentences with phrase «by altering the genes»

ONC201 may inhibit cancer stem cell self - renewals by altering their gene expression, according to a study published August 2, 2017 in the open - access journal PLOS ONE by Varun Vijay Prabhu from Oncoceutics, Inc., USA and colleagues.

Melanocytes respond by altering gene transcription, and these changes in gene expression profiles result in easily quantifiable phenotypes such as modified pigment production (a hallmark of melanocyte differentiation state) and changes in morphological cell properties.

Cells respond to diverse stimuli by altering gene activity.

Doctors generally do not treat disease by altering genes in people or changing how they work.

By altering the genes in male mosquitoes, researchers have just impaired the ability of these insects to reproduce.

Not exact matches

Many thoughtful citizens, including eminent scientists, oppose the deciphering and altering of the human gene structure, and are appalled by the proposed commercial uses of knowledge gained from such activities.

A GMO — or Genetically Modified Organism — often refers to ingredients that have been altered by using gene - splicing techniques in order to introduce a desirable trait.

A GMO — or Genetically Modified Organism — often refers to ingredient materials that have been altered by using gene - splicing techniques in order to introduce a desirable trait.

Genetically modified crops are plants in which genes are altered in the laboratory to make them perform in a very specific way, such as not being harmed by certain herbicides.

Using Atlantic killifish (Fundulus heteroclitus), the researchers examined whether mitochondrial - nuclear interactions alter the frequency of alternative forms of a gene that arise by mutation, called alleles, for over 11,000 nuclear DNA sequence variations within a population of the fish with mixed ancestry.

Experience may contribute to mental illness in a surprising way: by causing «epigenetic» changes — ones that turn genes on or off without altering the genes themselves

And their genes are easier to manipulate than those of their mammalian counterparts — by altering Sod1, Wu created flies that died after only about two weeks, a quarter of their normal life span.

CRISPR - Cas9 is a versatile and highly accurate gene - editing technology that allows researchers to modify specific parts of an organism's genome by altering sections of the DNA sequence.

For example, a team could soon create something strongly resembling a passenger pigeon by altering a band - tailed pigeon's genes to craft the extinct bird's long tail, red eyes and peach - colored breast.

The two - step process of TILT — getting sick upon toxicant exposure and failing to get well — may be driven by epigenetic changes, which occur when the environment alters the expression of genes without changing the core DNA code itself.

«By inserting the new sequence into the DNA, perhaps they are altering the gene in some other way,» he says.

The chemicals may contribute to diabetes by altering insulin production, disrupting related genes or changing glucose transport or fat metabolism, according to scientists.

Right: By altering both chromosomes, gene drives ensure both copies of the altered gene are inherited, leading to a 100 percent chance of passing it on.

As a result, thousands of products containing foreign or altered genes have been eaten by millions of people.

The work also shows we can alter development by changing the way genes are programmed, sidestepping the need for gene therapy.

Vitamin A and vitamin D are precursors to hormones that influence biological processes by entering the nucleus of a cell, binding to DNA, and altering the transcription of certain genes.

«They've done this by altering their genetic make - up; transferring drug - resistant genes between one another; and creating biofilms, which are multicellular communities where bacteria can be a thousand-fold more resistant to antibiotics.»

«Margery's experiments showed that the NS1 protein can alter expression of Hedgehog target genes on its own, without other viral proteins,» said Bier, professor and newly named holder of the Tata Chancellor's Endowed Professorship in Cell and Developmental Biology.

«The fact that the genetic code can simultaneously write two kinds of information means that many DNA changes that appear to alter protein sequences may actually cause disease by disrupting gene control programs or even both mechanisms simultaneously,» said Stamatoyannopoulos.

«We know that the DCC gene can be altered by experiences during adolescence,» said Dr. Flores.

But the effect — although measurable — is small: the gene alters IQ by just 1.29 points.

The researchers are continuing their work to gain more insights into the genes altered by this dysfunctional dopamine signaling.

Epigenetic changes do not alter the information encoded in the DNA sequence itself but determine whether and to what extent specific genes are used by cells.

By changing shape — becoming either more or less compact — chromatin can alter which genes are expressed.

The researchers further found that miR - 486 is itself regulated by the tumor - suppressor gene p53, the most frequently altered gene in human cancers, and that activity of miR - 486 is partially dependent upon functional p53.

Sometimes, by chance, bacterial genes mutate during reproduction, subtly altering the nature of the bug.

Sifting through this mountain of data, the scientists found three key genes that were altered by the NOTCH1 mutation and also acted as master regulators, turning off the critical pathways that normally prevent inflammation and calcification.

The research suggests that reducing production of the protein, called myoferlin, affects cancer cells in two primary ways: by changing the activation of many genes involved in metastasis in favor of normal cell behavior, and by altering mechanical properties of cancer cells — including their shape and ability to invade — so they are more likely to remain nested together rather than breaking away to travel to other tissues.

«Because many broadly expressed genes that play key roles in essential cellular functions are under the control of cell - specific enhancers, the ability to affect enhancer function by knocking down eRNAs could potentially provide a new strategy for altering gene expression in vivo in a cell - specific manner,» said Glass, noting that in his research, anti-sense oligonucleotides were developed in conjunction with Isis Pharmaceuticals, which suppressed enhancer activity and reduced expression in nearby genes.

Years of diabetes research carried out on mice whose DNA had been altered with a human growth hormone gene is now ripe for reinterpretation after a new study by researchers at KU Leuven confirms that the gene had an unintended effect on the mice's insulin production, a key variable in diabetes research.

Altering proteins in one part of the virus to achieve a certain benefit, such as more efficient gene transfer or reduced recognition by host immune cells, could end up destroying the structural integrity of the entire shell.

The study team, led by Joan C. Han, M.D., a former NICHD investigator now at the University of Tennessee Health Science Center, first analyzed the BDNF gene for naturally occurring genetic changes that alter levels of BDNF production.

For the first time, scientists have improved how a crop uses water by 25 percent without compromising yield by altering the expression of one gene that is found in all plants, as reported in Nature Communications.

In the Lyme bacteria's genome, the VlsE gene is preceded by «cassettes» which are normally not expressed, or made into individual proteins, but can recombine with VlsE to alter the expressed protein and thus present a novel challenge to a host's immune defenses.

Any change in those genes appears to alter your mental bank account or brain reserve by 2 or 3 percent.

The article «A gestational diet high in fat soluble vitamins alters expression of genes in 1 brain pathways and reduces sucrose preference, but not food intake, in Wistar male rat offspring» by Sanchez - Hernandez et al. was published in the journal Applied Physiology, Nutrition, and Metabolism.

More analysis showed that altering Cdk5 activity changed the level of several groups of genes that were also affected by aging, including those that control immunity, energy, and antioxidant activity.

Although bacteria have a seemingly limitless capacity to alter their genes by swapping bits of DNA between strains, this mechanism doesn't seem enough to account for the swift pace of change and the high variability of E. coli and other strains.Thomas Cebula of the U.S. Food and Drug Administration (FDA) wondered if this rapid evolution is being driven by microbes capable of much faster - than - normal variation.

At another inoculation site, where he injected a bacterial strain he had altered by removing the quorum - sensing gene, the healthy white flesh indicates the microbes have lost their appetite for potato.

In addition, the analysis provided some hints about how chemotaxis evolved from a simple signaling network that responds slowly to environmental cues — primarily by turning on genes — to a multiprotein system that can quickly alter a cell's course.

By boosting pat - 10 activity, they were able to cure worms that had been altered to express the Huntington's disease gene, and also extend the lifespan of normal worms.

Scientists think that changes in crotonylation can alter gene activity by turning genes on or off.

Hutchinson - Gilford progeria is caused by a spontaneous mutation during conception in a gene called LMNA, which encodes a protein called prelamin A. Progeria patients experience a buildup of an abnormal version of prelamin A in their cells that, among other changes, distorts the nucleus and alters gene expression.

«The computer model predicts that by altering this system by up - regulating some genes and down - regulating others, a 60 percent improvement could be achieved without any additional resource — so 60 percent more carbon could be assimilated for no more nitrogen,» Long said.

By comparing gene expression in the lungs of ducks infected with either highly or weakly pathogenic avian influenza H5N1 viruses, the team identified genes whose expression patterns were altered in response to avian influenza viruses.