Sentences with phrase «by cycling low»

Not exact matches

These risks and uncertainties include: Gilead's ability to achieve its anticipated full year 2018 financial results; Gilead's ability to sustain growth in revenues for its antiviral and other programs; the risk that private and public payers may be reluctant to provide, or continue to provide, coverage or reimbursement for new products, including Vosevi, Yescarta, Epclusa, Harvoni, Genvoya, Odefsey, Descovy, Biktarvy and Vemlidy ®; austerity measures in European countries that may increase the amount of discount required on Gilead's products; an increase in discounts, chargebacks and rebates due to ongoing contracts and future negotiations with commercial and government payers; a larger than anticipated shift in payer mix to more highly discounted payer segments and geographic regions and decreases in treatment duration; availability of funding for state AIDS Drug Assistance Programs (ADAPs); continued fluctuations in ADAP purchases driven by federal and state grant cycles which may not mirror patient demand and may cause fluctuations in Gilead's earnings; market share and price erosion caused by the introduction of generic versions of Viread and Truvada, an uncertain global macroeconomic environment; and potential amendments to the Affordable Care Act or other government action that could have the effect of lowering prices or reducing the number of insured patients; the possibility of unfavorable results from clinical trials involving investigational compounds; Gilead's ability to initiate clinical trials in its currently anticipated timeframes; the levels of inventory held by wholesalers and retailers which may cause fluctuations in Gilead's earnings; Kite's ability to develop and commercialize cell therapies utilizing the zinc finger nuclease technology platform and realize the benefits of the Sangamo partnership; Gilead's ability to submit new drug applications for new product candidates in the timelines currently anticipated; Gilead's ability to receive regulatory approvals in a timely manner or at all, for new and current products, including Biktarvy; Gilead's ability to successfully commercialize its products, including Biktarvy; the risk that physicians and patients may not see advantages of these products over other therapies and may therefore be reluctant to prescribe the products; Gilead's ability to successfully develop its hematology / oncology and inflammation / respiratory programs; safety and efficacy data from clinical studies may not warrant further development of Gilead's product candidates, including GS - 9620 and Yescarta in combination with Pfizer's utomilumab; Gilead's ability to pay dividends or complete its share repurchase program due to changes in its stock price, corporate or other market conditions; fluctuations in the foreign exchange rate of the U.S. dollar that may cause an unfavorable foreign currency exchange impact on Gilead's future revenues and pre-tax earnings; and other risks identified from time to time in Gilead's reports filed with the U.S. Securities and Exchange Commission (the SEC).

If current levels were to turn out, in hindsight, to be the final lows of this decline, I suspect that the overall return over the next cycle (by the time we do observe a full 20 % loss) will be as tame as we've seen since the bull market started in 2003.

Highly volatile, low - returning markets end in fear, which leads to higher - returning markets with much lower volatility, followed by the eventual greed that starts the cycle again.

Still, even a run - of - the - mill completion to the present market cycle would wipe out more than half of the market's gains since the 2009 low, so whatever gains the market experiences in the interim are likely to be transitory, and few investors will retain them by exiting anywhere near the top.

That would be a relatively low level by historical standards; in the past two tightening cycles by the Fed, the federal funds rate peaked at around 6 per cent.

From here, we expect the dynamics of this market cycle to resemble other periods when offensive valuations and extreme overvalued, overbought, overbullish syndromes were joined by deteriorating market internals (particularly when interest rates were off their lows).

In my view, investors who view current valuations as «justified relative to interest rates» are really saying that a decade of zero total returns on stocks is perfectly adequate compensation for the risk of a 45 - 55 % market loss over the completion of the current market cycle - a decline that would historically be merely run - of - the - mill given current valuations, and that certainly can not be precluded by appealing to low interest rates.

CenterSquare aims to uncover low relative price opportunities across sectors and at different turning points in the real estate cycle by looking beyond the obvious factors of stock price and underlying real estate value.

if they can find Banks willing to take a «long «position that will allow them to have a non-expanding debt load and interest only payments on a loan, they might be able to withstand the low price cycle until opec led by Saudi Arabia can get world producers to curtail production and elevate prices to a point where all producers are making some money.

Currency growth, by contrast, has been considerably lower and has exhibited little cyclicality since the early 1990s, in marked contrast to earlier cycles.

The S&P 500 was up over 300 points from the February and March lows largely in anticipation of «earnings season» but in the past two weeks, both the S&P and the NASDAQ have been hobbled by a «sell the news» behavioral quirk, which, for me, is a sure - fire signal that bigger investors are viewing Q1 / 2018 as the peak for the business cycle.

In general, historically low interest rates and a muted business cycle have kept pressure on financial stocks by constricting net interest margins and stifling credit activity.

The lower class citizens, led by the beautiful Maria, a combo of John the Baptist and the Virgin Mary, prophesy a coming savior who will break the endless cycle of fear and enslavement.

Constellation originally bought the business, previously known as BRL Hardy, in 2003 at the top of the wine cycle after exports had soared, helped along by the low Australian dollar.

I personally think fans respect of wenger is at an all time low, we will do the usual be in the top 6/7 by jan, buy a panic buy, get fourth and everyone's happy, there will be hundreds of rumours in the summer transfer window and we will be here again, until wenger leaves this is the cycle, we need to be aware players like Sanchez want to compete for trophies, he wasn't extatic with just the FA cup, if this carries on he will leave and I for one won't blame him.

Our problems seem to run in cycles of a few seasons, we can challenge against the big teams but struggle against mid-table sides, or we can beat the mid / lower - table teams and get d*ck ed by the big guns.

The Female Athlete Triad involves three distinct but inter - related conditions: energy deficiency caused by disordered eating, irregular menstrual cycle and low bone - mineral density.

With many of the low - end pumps, you must regulate the suction and cycles manually by pressing a lever or placing and removing your fingers over a port.

If your baby is fussing in your baby carrier, stop the stress - influencing cycle by consciously calming yourself, taking a few deep breaths and begin modeling the behavior you want your baby to have: Use slow motions, loosen your muscles and use a calm low voice.

It has been the practice for a woman trying to conceive to keep careful records of her monthly cycles, especially by keeping a log of her basal body temperature — the temperature of a 24 hour period where her temperature is lowest.

Agencies under the UJA - Federation umbrella have lost a total of $ 6 million due to Paterson's veto of legislative earmarks known as member - item grants, the latest in eight cycles of budget cuts that have rocked the non-sectarian network of special education, child care, mental health, immigrant and other services, lowering revenue by 5 to 7 percent, said Soloway.

Turnout at local elections tends to be very low (below 40 %), and the traction generated by the tree - felling case could have a positive effect in terms of the number of people that will go to the polls to elect one - thirds of Sheffield Council that are elected in this cycle, and the SCRCA mayor.

A statewide public financing system to elevate average New Yorkers» voices in our elections, buttressed by other comprehensive reforms — like lower limits on how much one person can contribute to a political candidate (now at an outrageous $ 60,800 for statewide candidates per election cycle) and strong independent enforcement of campaign finance laws — will reduce the power of big money special interests.

The «industrialization of food,» as author Paul Roberts puts it, is a relentless cycle driven by razor - thin price margins that force food processors to adopt more advanced techniques to produce even more food at lower prices.

Sarah, whose lower lip is bisected by a silver ring, has just ditched crew for the cycling team.

However, they are affected by temperature variations and suffer from low electric power and limited lifetime (often around a few hundred charge / discharge cycles).

By using a combination of crop growth, hydrological, carbon and nitrogen cycle models, researchers found that the estimated land suitable for bioenergy grasses — particularly Miscanthus, the most productive bioenergy crop — is limited, despite its relatively high biomass productivity and low water consumption per unit of ethanol.

While low - magnitude seismic events of tectonic origin typically have frequencies of 10 to 20 cycles per second, this shaking was dominated by frequencies of 2 to 4 cycles per second.

«One disadvantage appears to be some reduction in the proportion of short trips by walking, and in the (already) low level of cycling; these might be detrimental to the establishment of future travel habits bringing regular physical activity,» they suggest.

«We can help break this cycle by training and encouraging parents in low - resource settings to engage their children in a variety of age - appropriate activities.»

Unlike much of the 1990s, the 2003 - 11 period favored La Niña episodes, or natural cycles characterized by unusually low ocean temperatures in the eastern equatorial Pacific Ocean.

The proportion of dwarf novae may be lower than found in catalogs, or they may have a much smaller duty cycle in general as proposed by some population synthesis models and recent observations in the field.

Temperatures also jumped up by about 0.15 oC (0.27 oF) between the cool La Niña years (Green lines) of 1979 - 1989 and those of 1996 - 2008 (the eruption of Mount Pinatubo in 1991 lowered the Earth's temperatures in the midst of an El Niño cycle).

This new group of scientists find some weather disturbances were not from the El Nino, La Nina cycle, but apparently regulated by conditions in the Arctic — things like low sea ice, low or shorter season snow cover, and even «sudden stratospheric warming».

«At the start of the menstrual period, there is a very low level of oestrogen, but by mid cycle it has increased tenfold before falling down steeply again just before the next period.

You suffer from the various maladies that are exacerbated by poor sleep, such as weight issues, burnout, low libido, irregular menstrual cycles, fatigue, brain fog, depression, anxiety, panic, bipolar, or adult ADHD.

A general rule of thumb is to saturate your muscles with 20 grams of creatine in five - gram servings for a week, then bring the consumption down to 5 grams per day for maintenance, or you could cycle your creatine consumption by starting with.16 grams per pound -LRB-.35 g per kg) of bodyweight daily during the first week, then lowering the amount to.7 grams per pound -LRB-.15 g per kg) of bodyweight daily during week 2 - 4, then taking the fifth week off and repeating the cycle.

I personally cycle through many kinds of exercise that I enjoy, and like to keep it fresh by trying new things all the time — but body weight workouts are something I have relied on my whole life to keep me in the game during interim periods, when the weather was bad, when I was traveling, or as a simple, low - maintenance way to just get my shred on when the gym felt too far away.

If you see a purple day during a cycle, it is important to look back at trends in your oral readings to see if you can identify a second Cue Peak (a high oral reading followed by two lower oral readings).

When levels fall, low hormone levels are detected by the brain and the cycle repeats.

In simple terms, your basal body temperature is the temperature at which your body rests, which tends to be a bit lower than your «normal» temperature, usually 97 point something degrees F versus 98.6 degrees F. By taking your BBT each morning throughout your cycle you will be able to detect the natural rise in your basal body temperature that occurs just after ovulation.

If we were to graph this cycle, we would see a prominent peak in the oral readings followed by at least two days of lowered readings, and a «V» pattern in the vaginal readings ending on the pink box day, followed by a relatively flat line through the rest of the cycle.

When you're carb cycling to lose fat, you will have three low - carb days followed by one high - carb day.

Except in the exceptional case of those with great genetics, most of us who wish to get contest ready will need to restrict carbohydrates significantly and also practice carbohydrate cycling (having 3 days of low carb followed by 1 day of higher carbs).

It makes sense that sessions completed at lower intensity or at the beginning of a training cycle are best suited for, or perhaps least disadvantaged by, [train low] strategies.

Be advised, there are many «normal» looking personal trainers who make up for their poor routines by taking occasional drug cycles or low doses of bodybuilding drugs.

Ideally, body temperature drops naturally in the evening so by lowering the temperature in your bedroom you support this natural body cycle.

In a study conducted by researchers at McMaster University, subjects depleted glycogen stores by cycling and then followed either a high - or low - carb diet for 2 days and then did a 2 - hour leg workout.

Hadsall has come up with a cycling pattern that tricks your body into burning fat 24/7 by switching between low carb and high carb cycles in a very specific and strategic way.

The loss of menstrual cycles in women and reduced sex drive in both men and women who reach extremely low body fat levels might also be explained by low leptin levels.